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| 1 | Mechanisms of biliary carcinogenesis and growth显示文摘Cholangiocarcinoma is a rare cancer originating from the neoplastic transformation of the epithelial cells (i.e. cholangiocytes) that line the biliary tract. The prognosis for patients with cholangiocarcinoma is grim due to lack of viable treatment options. The increase in world-wide incidence and mortality from cholangiocarcinoma highlights the importance of understanding the intracellular mechanisms that trigger the neoplastic transformation of cholangiocytes and the growth of biliary cancers. The purpose of the following review is to address what has been learned over the past decade concerning the molecular basis of cholangiocarcinogenesis. The material presented is divided into two sections:(1) mechanisms regulating neoplastic transformation of cholangiocytes; and (2) factors regulating cholangiocarcinoma growth. An understanding of the growth regulatory mechanisms of cholangiocarcinoma will lead to the identification of therapeutic targets for this devastating cancer. | Candace Wise Metaneeya Pilanthananond Benjamin F Perry Gianfranco Alpini Michael McNeal Shannon S Glaser | 2008 | World Journal of Gastroenterology2008，14，19： | 5 |
| 2 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 3 | Measuring flow velocity at elevated temperature with a hot-wire anemometercalibrated in cold flow 显示文摘 | Benjamin S F | 2002 | International Journal of Heat and Mass Transfer2002，45，： | 1 |
| 4 | Conjugated polymer / lanthanide complex based blends as near-IR light emitting diodes 显示文摘 | Mohamed B Benjamin S H Timothy J F | 2002 | Polymer Preprints2002，43，1： | 1 |
| 5 | Cellular automaton models of traffic flow along a highway containing a junction显示文摘 | BENJAMIN S C JOHNSON N F HUI P M | 1996 | J phys A1996，29，： | 1 |
| 6 | Acceleration of the discrete element method (DEM) on a reconfigurable co-processor 显示文摘 | BENJAMIN C S STEVEN F Q ANDREW H C C | 2004 | Computers and Structures2004，82，2021： | 1 |
| 7 | Cellular au tomaton models of tra//ic flow along a highway con taining a junction显示文摘 | Benjamin S C Johnson N F Hui P M | 1996 | Physica A1996，29，31： | 1 |
| 8 | Magnetic resonance coupling as a potential means for wireless power transfer to multiple small receivers显示文摘 | BENJAMIN L C JAMES F H DANIEL D S | 2009 | IEEE transactions on power electronics2009，24，7： | 1 |
| 9 | Ovum dona-tion:examining the new Israeli law显示文摘 | Benjamin F Gruenbauma Zachary S | 2011 | Eur J Obstet Gy-necol Reprod Biol2011，7145，： | 1 |
| 10 | Model equations for long waves in nonlinear dispersive systems 显示文摘 | Benjamin T B F R S Bona J L Mahony J J | 1972 | Philos Trans R Soc London: Ser A1972，272，： | 1 |
| 11 | Cellular automata models of traffic flow along a highway containing a junction显示文摘 | Benjamin S C Johnson N F Hui B M | 1996 | J Phys1996，29，12： | 1 |
| 12 | Hemangiopericytoma of the central nervous system显示文摘 | Borg M F Benjamin C S | 1995 | Australas Radiol1995，39，1： | 1 |
| 13 | Objective and subjective outcomes in comparing three different aspheric in- traocular lens implants with their spherical counterparts 显示文摘 | Cuthbertson F M Dhingra S Benjamin L | 2009 | Eye (Lond)2009，23，4： | 1 |
| 14 | Cellular automaton models of traffic flow along a highway containing a junction 显示文摘 | Benjamin S C Johnson N F Hui P M | 1996 | Journal of Physics A1996，29，： | 1 |
| 15 | Zebrafish organizer development and germ-layer formation require nodal-related signals显示文摘 | BENJAMIN F GATES M A EGAN E S | 1998 | Nature1998，395，： | 1 |
| 16 | Model Equations for Long Waves in Nonlinear Dispersive Systems 显示文摘 | Benjamin T B F R S Bona J L Mahony J J | 1972 | Philos Trans R Soc London Ser A1972，272，： | 1 |
| 17 | Besolution of discrepant results for Candida species identification by using DNA probes显示文摘 | Coignard C Hurst S F Benjamin L E | 2004 | J Clin Microbiol2004，42，： | 1 |
| 18 | Chronic exogenous kisspeptin administration accelerates gonadal development in basses of the genus Morone显示文摘 | Benjamin H B Adam F S Matthew E | | 0，，162： | 1 |
| 19 | Validation of Fully Implicit, Parallel Finite Element Simulations of Laminar Hypersonic Flows 显示文摘 | Benjamin S K Graham F G | 2006 | AIAA Journal2006，48，： | 1 |
| 20 | Regulation of Parkinsonian Motor Behaviours by Optogenetic Control of Basal Ganglia Circuitry显示文摘 | Alexxai V K Benjamin S F Philip R L P | 2010 | Nature2010，466，29： | 1 |
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