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| 1 | Global secretome analysis identifies novel mediators of bone metastasis显示文摘骨头是稳固的肿瘤的远转移的一个最普通的地点。分泌蛋白质被知道影响在变形癌症房间和骨头基质之间的病理学的相互作用。为了包括地介绍,分泌了与骨头转移联系的蛋白质,我们使用了量、非量的集体 spectrometry 全球性分析改变从多重种类和癌症的变形能力打的骨头的九根细胞线的 secretomes。由比较父母房间和他们的骨头的 secretomes 变形衍生物,我们识别了特别地在这些房间线与骨头转移被联系的分泌蛋白质。我们然后合并了大临床的转移数据集的生物信息的分析获得强烈与临床、试验性的骨头转移被联系的几个功能的班的候选人小说骨头转移蛋白质的一张表。选择蛋白质的功能的确认显示在 vivo,骨头转移能被高表示支持(1 ) 唾液的 cystatins CST1, CST2,和 CST4;(2 ) plasminogen 使活跃之物小块地和 PLAU;或(3 ) 骨胶原功能蛋白质 PLOD2 和 COL6A1。总的来说,我们的学习揭开了骨头转移并且因此的几个新分泌调停人证明 secretome 分析是为新奇 biomarkers 和候选人的鉴定的一个强大的方法治疗学的目标。 | Maria Andres Blanco Gary LeRoy Zia Khan Ma a Ale kovi Barry M Zee Benjamin A Garcia Yibin Kang | 2012 | Cell Research2012，22，9： | 12 |
| 2 | Current and future molecular diagnostics in colorectal cancer and colorectal adenoma显示文摘Colorectal cancer(CRC)is one of the most prevalent cancers in developed countries.On the other hand,CRC is also one of the most curable cancers if it is detected in early stages through regular colonoscopy or sigmoidoscopy.Since CRC develops slowly from precancerous lesions,early detection can reduce both the incidence and mortality of the disease.Fecal occult blood test is a widely used non-invasive screening tool for CRC.Although fecal occult blood test is simple and cost-effective in screening CRC,there is room for improvement in terms of the accuracy of the test.Genetic dysregulations have been found to play an important role in CRC development.With better understanding of the molecular basis of CRC,there is a growing expectation on the development of diagnostic tests based on more sensitive and specific molecular markers and those tests may provide a breakthrough to the limitations of current screening tests for CRC.In this review,the molecular basis of CRC development,the characteristics and applications of different non-invasive molecular biomarkers,as well as the technologies available for the detection were discussed.This review intended to provide a summary on the current and future molecular diagnostics in CRC and its pre-malignant state,colorectal adenoma. | Andy Hin-Fung Tsang Ka-Ho Cheng Apple Siu-Ping Wong Simon Siu-Man Ng Brigette Buig-Yue Ma Charles Ming-Lok Chan Nancy Bo-Yin Tsui Lawrence Wing-Chi Chan Benjamin Yat-Ming Yung Sze-Chuen Cesar Wong | 2014 | World Journal of Gastroenterology2014，20，14： | 7 |
| 3 | Utility of MtCOI polymerase chain reaction-restriction fragment length polymorphism in differentiating between Q and B whitefly Bemisia tabaci biotypes显示文摘侵略,杀虫药剂抵抗, Q 白苍蝇遗传因子型,逐渐地经由植物材料的调停人的运动包括 US 传播了到另外的国家。我们估计了基于 VspI 的 mtCOI 的用途(线粒体细胞色素 oxidase 我) 是的聚合酶链反应限制碎片长度多型性(PCR-RFLP ) 技术为在亚利桑那把 Q 区分开来与主导的 B 遗传因子型的一种快速、划算、可靠的选择。用定序的标准 mtCOI 基因和 mtCOI PCR-RFLP 技术,我们八个白苍蝇五个个人拉紧的 biotyped 各在亚利桑那在不同地点从一品红和棉花收集了。完全的词语索引在二个方法之间被观察,与作为象 B 遗传因子型的 Q 遗传因子型和五件样品被识别的三紧张。我们也在在 GenBank 数据库当前可得到的 B 和 Q 遗传因子型白人苍蝇为 VspI 多型性扫描了 mtCOI 基因序列。这全球屏蔽分别地为 Q 和 B 遗传因子型揭示了三和四种 VspI 多态的类型的存在。不过,所有三个 VspI 多态的 Q 遗传因子型白人苍蝇分享了能被用来把 Q 遗传因子型区分开来与识别的四个 VspI 多态的 B 遗传因子型白人苍蝇的一个普通、唯一的 VspI 地点。这些结果证明基于 VspI 的 mtCOI 基因 PCR-RFLP 为区分白色在 US 并且在其它地方飞的 Q 和 B 遗传因子型提供一个可靠诊断工具。 | Wei-Hua Ma Xian-Chun Li Timothy J. Dennehy Chao-Liang Lei Mo Wang Benjamin A. Degain Robert L. Nichols | 2009 | Insect Science2009，16，2： | 5 |
| 4 | Template-free synthesis of carbon doped TiO2 mesoporous microplates for enhanced visible light photodegradation显示文摘钛二氧化物(TiO 2) 广泛地为太阳能变换和环境补习作为稳固的光催化剂被采用。与控制粒子尺寸和缩小的 bandgap 构造多孔的 TiO 2 的能力是为设计的一个必要要求高度有效并且 recyclable 光催化剂。这里,我们报导没有模板的醋酸与高 crystallinity 和 mesoporous 结构为可见光的应答的做碳的 TiO 2 microplates 的合成导致了方法。从醋酸导出的撤退电子的有二齿的羧化物 ligands 能缩小 TiO 2 的 bandgap,这被显示出(1.84 ? eV ) 实质地。而且,结果的 microplate 光催化剂展出优秀 photocatalytic 效率和稳固液体的分离性能,它将为未来是有益的工业应用。 | Juming Liu Lu Han Huiyan Ma Hao Tian Jucai Yang Qiancheng Zhang Benjamin J. Seligmann Shaobin Wang Jian Liu | 2016 | Science Bulletin2016，61，19： | 4 |
| 5 | Celecoxib-related gastroduodenal ulcer and cardiovascular events in a randomized trial for gastric cancer prevention显示文摘AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study.METHODS: From 2004 to 2006, a total of 1024 Chinese patients (aged 35 to 64 years) with severe chronic atrophic gastritis, intestinal metaplasia or dysplasia were randomly assigned to receive 200 mg of celecoxib twice daily or placebo in Linqu County (Shandong Province, China), a high-risk area of gastric cancer. All gastroduodenal ulcer and cardiovascular events occurred were recorded and the patients were followed up for 1.5 years after treatment. At the end of the trial, a systematic interview survey about other adverse events was conducted. RESULTS: Gastroduodenal ulcer was detected in 19 of 463 (3.72%) patients who received celecoxib and 17 of 473 (3.31%) patients who received placebo, respectively (odds ratio = 1.13, 95% CI = 0.58-2.19). Cardiovascular (CV) events occurred in 4 patients who received celecoxib and in 5 patients who received placebo, respectively. Compared with those who received placebo, patients who received celecoxib had no signif icant increase in occurrence of CV events (hazard ratio = 0.84, 95% CI = 0.23-3.15). Among the adverse events acquired by interview survey, only the frequency of bloating was signif icantly higher in patients treated with celecoxib than in those treated with placebo. CONCLUSION: Treatment of gastric cancer with celecoxib is not associated with increased risk of gastroduodenal ulcer and cardiovascular events. | Guo-Shuang Feng Jun-Ling Ma Benjamin CY Wong Lian Zhang Wei-Dong Liu Kai-Feng Pan Lin Shen Xiao-Dong Zhang Jie Li Harry HX Xia Ji-You Li Shiu Kum Lam Wei-Cheng You | 2008 | World Journal of Gastroenterology2008，14，28： | 4 |
| 6 | Accelerated design and characterization of non-uniform cellular materials via a machine-learning based framework显示文摘Cellular materials,widely found in engineered and nature systems,are highly dependent on their geometric arrangement.A nonuniform arrangement could lead to a significant variation of mechanical properties while bringing challenges in material design.Here,this proof-of-concept study demonstrates a machine-learning based framework with the capability of accelerated characterization and pattern generation.Results showed that the proposed framework is capable of predicting the mechanical response curve of any given geometric pattern within the design domain under appropriate neural network architecture and parameters.Additionally,the framework is capable of generating matching geometric patterns for a targeted response through a databank constructed from our machine learning model.The accuracy of the predictions was verified with finite element simulations and the sources of errors were identified.Overall,our machine-learning based framework can boost the design efficiency of cellular materials at unit level,and open new avenues for the programmability of function at system level. | Chunping Ma Zhiwei Zhang Benjamin Luce Simon Pusateri Binglin Xie Mohammad H.Rafiei Nan Hu | 2020 | npj Computational Materials2020，，1： | 3 |
| 7 | Occult bilateral involvement in stage I epithelial ovarian cancer显示文摘 | Benjamin I Morgan MA Rubin SC | 1999 | Gynecol Oncol1999，72，3： | 1 |
| 8 | Esophageal varices on computed tomography and subsequent variceal hemorrhage显示文摘 | Ma Somsouk Katherine To’o Mujtaba Ali Eric Vittinghoff Benjamin M. Yeh Judy Yee Alex Monto John M. Inadomi Rizwan Aslam | 2014 | Abdominal Imaging2014，，2： | 1 |
| 9 | In vivo T(lrho)and T2mapping of articular cartilage in osteoarthritis of the knee using3 T MRI显示文摘 | Li X Benjamin Ma C Link TM | 2007 | Osteoarthritis Cartilage2007，15，7： | 1 |
| 10 | Quality of life and disability in patients with treatment-failure gout 显示文摘 | BECKER MA SCHUMACHER HR BENJAMIN KL | 2009 | J Rheumatol2009，36，5： | 1 |
| 11 | Transformation of the generalized traveling-sales man problem into the standard traveling-salesman problem 显示文摘 | Lien Yao-Nan Ma Eva Benjamin W W | 1993 | Information Science1993，74，12： | 1 |
| 12 | In vivo T(1rho)and T(2) mapping of articular cartilage in osteoarthritis of the knee using 3T MRI显示文摘 | Li X Benjamin Ma C Link T M | 2007 | Osteoarthritis Cartilage2007，15，7： | 1 |
| 13 | Glucagon-like peptide-2 enhances intestinal epithelial barrier function of both transcellular and paracellular pathways in the mouse显示文摘 | Benjamin MA Mckay DM Yang PC | 2000 | Gut2000，47，： | 1 |
| 14 | In vivo T(1rho) and T2 mapping of articular cartilage in osteoarthritis of the knee using 3T MRI显示文摘 | Li X Benjamin Ma C Link TM | 2007 | Osteoarthritis Cartilage2007，15，7： | 1 |
| 15 | Transformation of the generalized trav-eling-salesman an problem into the standard trav2eling2salesman problem显示文摘 | Lien Y N Ma E Wah Benjamin W S | 1993 | Information Science~1993，74，12： | 1 |
| 16 | Occult bilateral involvement in stage I epithelial ovarian cancer显示文摘 | Benjamin I Morgan MA Rubin SC | 1999 | Gynecol Oncol1999，72，： | 1 |
| 17 | The influence of disuse on bone microstructure and mechanics assessed by HR-pQCT显示文摘 | Galateia J Kazakia Willy Tjong Jasmine A Nirody Andrew J Burghardt Julio Carballido-Gamio Janina M Patsch Thomas Link Brian T Feeley C Benjamin Ma | 2014 | Bone2014，63，： | 1 |
| 18 | Electrospun Nanofibrous Adsorption Membranes for Wastewater Treatment:Mechanical Strength Enhancement显示文摘Functional nanofibrous membranes fabricated by electrospinning technology have attracted much attention in the removal of heavy metal ions from contaminated wastewater.The high specific surface area,high porosity and ease of functionality create an enhanced throughput and high adsorption capacity of the nanofibrous membrane.However,the relatively poor mechanical properties of the membrane with a non-woven nanofibrous structure are one of the major concerns,which can limit the applications in wastewater treatment.Different strategies and methodologies were explored to address the problems and were reviewed in this work,highlighting the possibilities of overcoming the poor mechanical properties of the nanofibrous membrane and to ensure the recyclability and reusability of the membrane during the adsorption process. | XIN Rui MA Hongyang Shyam Venkateswaran Benjamin S.Hsiao | 2021 | Chemical Research in Chinese Universities2021，37，3： | 1 |
| 19 | Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery:a report of the International Brachial Artery Reactivity Task Force显示文摘 | Corretti MC Anderson TJ Benjamin EJ Celermajer D Charbon-neau F Creager MA Deanfield J Drexler H Gerhard-Herman M Herrington D Vallance P Vita J Vogel R | | 0，，2： | 1 |
| 20 | Occult bilatieral involvement in stage 1 epithelianl ovarian cancer显示文摘 | Benjamin I Morgan MA Rubin SC | 1999 | Gynecol Oncol1999，72，3： | 1 |
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