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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization显示文摘AIM To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver radioembolization.METHODS We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients wereseen in clinic one month after radioembolization and then at 2-3 mo intervals. We assessed the influence of FDG tumor uptake on outcomes including local liver control(LLC), distant liver control(DLC), time to distant metastases(DM), progression free survival(PFS) and overall survival(OS).RESULTS The majority of patients were males(n = 25, 74%), and had Child Pugh Class A(n = 31, 91%), with a median age of 68 years(46-84 years). FDG-avid disease was found in 19(56%) patients with SUVmax ranging from 3 to 20. Female patients were more likely to have an FDG-avid HCC(P = 0.02). Median follow up of patients following radioembolization was 12 months(1.2-62.8 mo). FDG-avid disease was associated with a decreased 1 year LLC, DLC, DM and PFS(P < 0.05). Using multivariate analysis, FDG avidity predicted for LLC, DLC, and PFS(all P < 0.05).CONCLUSION In this retrospective study, pre-treatment HCC FDGavidity was found to be associated with worse LLC, DLC, and PFS following radioembolization. Larger studies are needed to validate our initial findings to assess the role of F-18-FDG PET/CT scans as biomarker for patients with HCC following radioembolization. | Yazan Abuodeh Arash O Naghavi Kamran A Ahmed Puja S Venkat Youngchul Kim Bela Kis Junsung Choi Benjamin Biebel Jennifer Sweeney Daniel A Anaya Richard Kim Mokenge Malafa Jessica M Frakes Sarah E Hoffe Ghassan El-Haddad | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 3 | Condensed tannin biosynthesis genes are regulated separately from other flavonoid biosynthesis genes in apple fruit skin显示文摘 | Adam M T Benjamin E U Robinson S P | 2006 | Plant Science2006，170，： | 1 |
| 4 | Independent risk factors for atrialfibrillation in a populationg-hased cohort: the Framingham heart study显示文摘 | Benjamin E J Levy D Vaziri S M | 1994 | JAMA1994，271，11： | 1 |
| 5 | Sudden sensorineural hearing loss显示文摘 | Benjamin E Schreiber Charlotte Agrup Dorian O Haskard Linda M Luxon | 2010 | The Lancet2010，，9721： | 1 |
| 6 | Value of post-licensure data on benefits and risks of vaccination to inform vaccine policy: The example of rotavirus vaccines显示文摘 | Umesh D Parashar Margaret M Cortese Daniel C Payne Benjamin Lopman Catherine Yen Jacqueline E Tate | 2015 | Vaccine2015，，： | 1 |
| 7 | Mutation scanning of the p53 tumor suppressor gene in renal and liver transplant patients in Hungary 显示文摘 | Sarvary E Nagy P Benjamin A Szoke M Remport A Jansen J | 2005 | Transpl Proc2005，37，： | 1 |
| 8 | Impact of Childhood Inguinal Hernia Repair in Adulthood: 50 Years of Follow-UpI显示文摘 | Benjamin Zendejas Abdalla E · Zarroug Young M * Erben | 2010 | Journal of the American College of Surgeons2010，211，6： | 1 |
| 9 | Impact of glucose intolerance and insulin resistance on cardiac structure and function显示文摘 | KUTTER M K BENJAMIN E J LARSON | 2003 | Circulation2003，107，3： | 1 |
| 10 | The bedside insertion of inferior vena cava filters using ultrasound guidance 显示文摘 | UPPAL B FLINN W R Benjamin M E | 2007 | Perspect Vasc Surg Endovasc Ther2007，19，1： | 1 |
| 11 | Supercritical water oxidation of methylamine显示文摘 | Benjamin K M Savage P E | 2005 | Industrial&Engineering Chemistry Research2005，44，14： | 1 |
| 12 | Sterically engineered perylene dyes for high efficiency oriented fluorophore luminescent solar eoncentrators显示文摘 | Benjamin W E Veit D R Perkins M J | 2014 | Chemistry of Materials2014，26，3： | 1 |
| 13 | A simple model for complex dynamical transitions in epidemics显示文摘 | Pejman R Benjamin M B | 2000 | Science2000，287，： | 1 |
| 14 | Impact of heart rate and PR-interval on Doppler indexes of left ventricular diastolic filling in an elderly cohort (the Framingham heart study)显示文摘 | Galderisi M Benjamin E Evans J | 1993 | Am J Cardiol1993，72，： | 1 |
| 15 | Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vosodilation of the brachial artery:A report of the international brachial artery reactivity task force显示文摘 | Corretti M C Anderson T J Benjamin E J | 2002 | J Am Coll Cardiol2002，39，2： | 1 |
| 16 | Guidelines for the ultrasound assessment of endothelial-dependent flow-me diated vasodilation of the brachial artery, a report of the Interna tional Braehial Artery Reactivity Task Force 显示文摘 | Corretti M C Anderson T J Benjamin E F | 2002 | J Am Coil Cardiol2002，39，25： | 1 |
| 17 | Thiophene- containing poly ( arylene-ethynylene )-alt-poly ( arylenevinylene)s: Synthesis, characterisation and optical properties显示文摘 | Daniel A M E Le H N Benjamin C | 2005 | Polymer2005，46，23： | 1 |
| 18 | CpG-depleted adeno-associated virus vectors evade immune detection显示文摘 | Faust Susan M Bell Peter Cutler Benjamin J Ashley Scott N Zhu Yanqing Rabinowitz Joseph E Wilson James M | 2013 | Journal of Clinical Investigation2013，，7： | 1 |
| 19 | An intervention to promote healthy weight:Nutrition and Physical Activity Self-Assessment for Child Care(NAP SACC)theory and design显示文摘 | Ammerman A S Ward D S Benjamin S E Ball S C Sommers J K Molloy M | 2007 | Preventing chronic disease2007，4，3： | 1 |
| 20 | Post-transcriptional regulation of glucose transporter-1 by an AU-rich element in the 3 ′ UTR and by hnRNP A2显示文摘 | Mary E Griffin B.JoNell Hamilton Kristen M Roy Min Du Alicia M Willson Benjamin J Keenan Xiao Wei Wang Ralph C Nichols | 2004 | Biochemical and Biophysical Research Communications2004，，4： | 1 |
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