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| 1 | Method for rapid on-site identification of VOCs显示文摘Rapid on-site identification of volatile organic compounds (VOCs) in ambient air is an important first step in remediation efforts. This study describes modification of a commercially available, portable GC/MS system and development of an analysis protocol for rapid (< 3 min) sampling and identification of VOCs typically found at contaminated sites at the low ppbv level. | Justin D Fair William F Bailey Robert A Felty Amy E Gifford Benjamin Shultes Leslie H Volles | 2009 | Journal of Environmental Sciences2009，21，7： | 8 |
| 2 | Artificial intelligence in gastroenterology: A state-of-the-art review显示文摘The development of artificial intelligence(AI)has increased dramatically in the last 20 years,with clinical applications progressively being explored for most of the medical specialties.The field of gastroenterology and hepatology,substantially reliant on vast amounts of imaging studies,is not an exception.The clinical applications of AI systems in this field include the identification of premalignant or malignant lesions(e.g.,identification of dysplasia or esophageal adenocarcinoma in Barrett’s esophagus,pancreatic malignancies),detection of lesions(e.g.,polyp identification and classification,small-bowel bleeding lesion on capsule endoscopy,pancreatic cystic lesions),development of objective scoring systems for risk stratification,predicting disease prognosis or treatment response[e.g.,determining survival in patients post-resection of hepatocellular carcinoma),determining which patients with inflammatory bowel disease(IBD)will benefit from biologic therapy],or evaluation of metrics such as bowel preparation score or quality of endoscopic examination.The objective of this comprehensive review is to analyze the available AI-related studies pertaining to the entirety of the gastrointestinal tract,including the upper,middle and lower tracts;IBD;the hepatobiliary system;and the pancreas,discussing the findings and clinical applications,as well as outlining the current limitations and future directions in this field. | Paul T Kröner Megan ML Engels Benjamin S Glicksberg Kipp W Johnson Obaie Mzaik Jeanin E van Hooft Michael B Wallace Hashem B El-Serag Chayakrit Krittanawong | 2021 | World Journal of Gastroenterology2021，27，40： | 6 |
| 3 | 血管紧张素受体阻断剂预防男性人群痴呆发生风险研究:前瞻性队列分析(摘要)显示文摘目的探讨血管紧张素受体拮抗剂能否预防阿尔茨海默病和老年痴呆症,或同时减少两种疾病的进展。
设计前瞻性队列分析。
资料来源2002—2006年美国退伍军人数据库。 | Nien-Chen Li Austin Lee Rachel A Whitmer Miia Kivipelto Elizabeth Lawler Lewis E Kazis Benjamin Wolozin 夏曙(译) 于世英(校) | 2010 | 英国医学杂志中文版2010，13，2： | 5 |
| 4 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 5 | Bone graft substitutes for spine fusion: A brief review显示文摘Bone graft substitutes are widely used in the field of orthopedics and are extensively used to promote vertebral fusion. Fusion is the most common technique in spine surgery and is used to treat morbidities and relieve discomfort. Allograft and autograft bone substitutes are currently the most commonly used bone grafts to promote fusion. These approaches pose limitations and present complications to the patient. Numerous alternative bone graft substitutes are on the market or have been developed and proposed for application. These options have attempted to promote spine fusion by enhancing osteogenic properties. In this review, we reviewed biology of spine fusion and the current advances in biomedical materials and biological strategies for application in surgical spine fusion. Our findings illustrate that, while many bone graft substitutes perform well as bone graft extenders, only osteoinductive proteins(recombinant bone morphogenetic proteins-2 and osteogenic protein-1) provide evidence for use as both bone enhancers and bone substitutes for specific types of spinal fusion. Tissue engineered hydrogels, synthetic polymer composites and viral based gene therapy also holds the potential to be used for spine fusion in future, though warrants further investigation to be used in clinical practice. | Ashim Gupta Nitin Kukkar Kevin Sharif Benjamin J Main Christine E Albers Saadiq F El-Amin Ⅲ | 2015 | World Journal of Orthopedics2015，6，6： | 4 |
| 6 | Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization显示文摘AIM To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver radioembolization.METHODS We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients wereseen in clinic one month after radioembolization and then at 2-3 mo intervals. We assessed the influence of FDG tumor uptake on outcomes including local liver control(LLC), distant liver control(DLC), time to distant metastases(DM), progression free survival(PFS) and overall survival(OS).RESULTS The majority of patients were males(n = 25, 74%), and had Child Pugh Class A(n = 31, 91%), with a median age of 68 years(46-84 years). FDG-avid disease was found in 19(56%) patients with SUVmax ranging from 3 to 20. Female patients were more likely to have an FDG-avid HCC(P = 0.02). Median follow up of patients following radioembolization was 12 months(1.2-62.8 mo). FDG-avid disease was associated with a decreased 1 year LLC, DLC, DM and PFS(P < 0.05). Using multivariate analysis, FDG avidity predicted for LLC, DLC, and PFS(all P < 0.05).CONCLUSION In this retrospective study, pre-treatment HCC FDGavidity was found to be associated with worse LLC, DLC, and PFS following radioembolization. Larger studies are needed to validate our initial findings to assess the role of F-18-FDG PET/CT scans as biomarker for patients with HCC following radioembolization. | Yazan Abuodeh Arash O Naghavi Kamran A Ahmed Puja S Venkat Youngchul Kim Bela Kis Junsung Choi Benjamin Biebel Jennifer Sweeney Daniel A Anaya Richard Kim Mokenge Malafa Jessica M Frakes Sarah E Hoffe Ghassan El-Haddad | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 7 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 8 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 9 | Improving intermittent androgen deprivation therapy: lessons learned from basic and translational research显示文摘断断续续的雄激素剥夺治疗(IADT ) 在有 nonmetastatic 疾病的前列腺癌症病人是连续雄激素剥夺治疗(ADT ) 的一种选择。ADT 与象热闪光,性机能障碍,贫血症,疲劳,肌肉质量的损失,骨质疏松症,新陈代谢的症候群和早熟的心血管的疾病那样的众多的副作用被联系。IADT 与改进生活并且到前列腺癌症的延期前进的质量到阉割抵抗的意愿被开发。由与 ADT 相比的 IADT 的生活的稍微改进的质量的好处在多重临床的试用被表明。IADT 被注意是到在有前列腺癌症,但是在与变形前列腺癌症在病人执行的研究的生物化学的复发的病人的 ADT 的 noninferior,结果是不确定的。我们的最近的研究建议 5 个 alpha-reductase 禁止者的管理能显著地在 IADT 的离开周期期间延长当离开周期持续时间是短的时,忍受雄激素敏感的前列腺肿瘤的老鼠的幸存。这评论在动物模型和这发现进诊所的潜在的翻译在 IADT 讨论 5 alpha-reductase 抑制的幸存利益。 | Rahul A Parikh Laura E Pascal Benjamin J Davieses Zhou Wang | 2014 | Asian Journal of Andrology2014，16，4： | 2 |
| 10 | Effects of flavonoids on the release of reactive oxygen species by stimulated human neutrophils显示文摘 | Benjamin Limasset Christian L E Doucen Jean Christophe Dore | 1993 | Biochemical Pharmacology1993，46，7： | 2 |
| 11 | Condensed tannin biosynthesis genes are regulated separately from other flavonoid biosynthesis genes in apple fruit skin显示文摘 | Adam M T Benjamin E U Robinson S P | 2006 | Plant Science2006，170，： | 1 |
| 12 | Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors:Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal显示文摘 | Benjamin LE Keshet E | 1997 | Proc Natl Acad Sci USA1997，94，16： | 1 |
| 13 | Single -molecule measurement of protein folding kinetics 显示文摘 | Lipman E A Benjamin S William A E | 2003 | Science2003，301，： | 1 |
| 14 | Independent risk factors for atrialfibrillation in a populationg-hased cohort: the Framingham heart study显示文摘 | Benjamin E J Levy D Vaziri S M | 1994 | JAMA1994，271，11： | 1 |
| 15 | Evaluation of fatty acid amides in the carrageenan-induced paw edema model显示文摘 | Laura E Wise Roberta Cannavacciulo Benjamin F Cravatt | | 0，，01： | 1 |
| 16 | Accuracy of ACARS Wind and Temperature Observations Determined by Collocation显示文摘 | Stanley G Benjamin Barry E Schwartz | 1999 | Weather and Forecasting1999，14，： | 1 |
| 17 | Prevalence, incidence,prognosis, and predisposing conditions for atrial fibrillation: population-based estimates显示文摘 | Kannel W B Wolf P A Benjamin E J | 1998 | Am J Cardiol1998，82，8： | 1 |
| 18 | Adriamycin cardiomyopathy: risk factors显示文摘 | MINOW R A BENJAMIN R S LEE E T | 1977 | Cancer1977，39，4： | 1 |
| 19 | Mechanism of Mechanicalalloying显示文摘 | BENJAMIN J S VOLIN T E | 1974 | Metallurgical Transaction1974，5，8： | 1 |
| 20 | Prevalence,incidence prognosis,and predisposing conditions for atrial fibrillation:population based estimates显示文摘 | Kannel W B Wolf P A Benjamin E J | 1998 | Am J Cardiol1998，82，8： | 1 |
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