|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Alternative splicing as a biomarker and potential target for drug discovery显示文摘其他的拼接在 pre-mRNA 成熟期间是 multi-exonic 基因表示的一个关键过程。在这个过程,基因的特别 exons 将被包括在以内或从最后的成熟 mRNA,和产生抄本排除了产生多样的蛋白质 isoforms。最近的证据证明有多重 exons 的约 95% 人的基因经历在 pre-mRNA 成熟期间的其他的拼接。因此,其他的拼接在生理的进程和房间开发程序起一个关键作用,其他的拼接的 and.dysregulation 高度与人的疾病被联系例如癌症,糖尿病和 neurodegenerative 疾病。在这评论,我们讨论其他的拼接的规定,检验在其他的拼接和人的疾病之间的关系,并且描述修改其他的拼接的几条途径,它能帮助人的疾病诊断和治疗。 | Kai-qin LE Bellur S PRABHAKAR Wan-jin HONG Liang-cheng LI | 2015 | Acta Pharmacologica Sinica2015，36，10： | 4 |
| 2 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 3 | Identification, synthesis and characterization of process related impurities of benidipine hydrochloride, stress-testing/stability studies and HPLC/UPLC method validations显示文摘Benidipine hydrochloride, used as an antihypertensive agent and long-acting calcium antagonist, is synthesized for commercial use as a drug substance in highly pure form. During the synthetic process development studies of benidipine, process related impurities were detected. These impurities were identi fi ed, synthesized and characterized and mechanisms of their formation were discussed in detail.After all standardization procedures, they were used as reference standards for analytical studies. In addition, a separate HPLC method was developed and validated for detection of residual 1-benzylpiperidin-3-ol(Ben-2), which is used during benidipine synthesis and controlled as a potential process related impurity. As complementary of this work, stress-testing studies of benidipine were carried out under speci fi ed conditions and a stability-indicating UPLC assay method was developed, validated and used during stability studies of benidipine. | Esen Bellur Atici Bekir Karl??a | 2015 | Journal of Pharmaceutical Analysis2015，5，4： | 2 |
| 4 | Current Perspective on the Pathogenesis of Graves’ Disease and Ophthalmopathy显示文摘 | Bellur S. Prabhakar Rebecca S. Bahn Terry J. Smith | 2003 | Endocrine Reviews2003，，6： | 1 |
| 5 | A Taxonomy of QoS- aware, Adaptive Event-dissemination Middleware显示文摘 | Mahambre S P Kumar M Bellur U | 2007 | IEEE Internet Computing2007，11，4： | 1 |
| 6 | HIF-2 alpha regulates glyceraldehyde-3-phosphate dehydrogenase expression in endothelial cells显示文摘 | Graven KK Bellur D Klahn BD | 2003 | Biochim Biophys Acta2003，1626，13： | 1 |
| 7 | Photochemical rearrangement of ot-chloro-propio- phenones to a-arylpropanoic acids: Studies of chirality transfer and synthesis of (S)-( + )-ibuprofen and (S)- ( + ) -ketoprofen 显示文摘 | Sonawane Harikisan Bellur Nanjundiah S Kulkami Dilip G | 1994 | Tetrahedron1994，50，4： | 1 |
| 8 | Quantitative determination of two polymorphic forms of imatinib mesylate in a drug substance and tablet formulation by X-ray powder diffraction,differential scanning calorimetry and attenuated total reflectance Fourier transform infrared spectroscopy显示文摘 | Bellur Atici E Karlga B | 2015 | J Pharm Biomed Anal2015，114，： | 1 |
| 9 | Directional control of an advanced airship显示文摘 | Bellur L Nagabhushan | 1996 | Journal of Aircraft1996，33，5： | 1 |
| 10 | Autosomal-dominant retinitis pigmentosa caused by a mutation in SNRNP200, a gene required for unwinding of U4/U6 snRNAs显示文摘 | Zhao C Bellur DL Lu S | 2009 | Am JHum Genet2009，85，5： | 1 |
| 11 | Mean platelet volume in Type 2 diabetes meliitus显示文摘 | Thomas Alex Kodiatte Udaya Kumar Manikyam Suraksha Bellur Rao | 2012 | J Lab Physicians2012，4，1： | 1 |
| 12 | Low parasitic resistance contacts for scaled ULSI devices显示文摘 | OSBURN C M BELLUR K R | 1998 | Thin Solid Films1998，332，12： | 1 |
| 13 | Peduncular hallucinosis:magnetic resonance imaging com rmation of mesencephalic infarction during life显示文摘 | Bellur SN | 1987 | Ann Neurol1987，21，： | 1 |
| 14 | Harmonic winding losses in the transformer of a forward pulse width modulated DC-DC converter for continuous conduction mode显示文摘 | Murthy Bellur Kazimierczuk M | 2012 | Power Electronics IET2012，5，2： | 1 |
| 15 | Validation of the Oxford classification of IgA nephropathy in cohorts with different presenta- tions and treatments显示文摘 | Coppo R Troyanov S Bellur S | 2014 | Kidney Int2014，86，4： | 1 |
| 16 | Current Perspective on the Pathogenesis of Graves’ Disease and Ophthalmopathy显示文摘 | Bellur S. Prabhakar Rebecca S. Bahn Terry J. Smith | 2003 | Endocrine Reviews2003，，6： | 1 |
| 17 | Granulocyte macrophage colony‐stimulating factor treatment of a patient in myasthenic crisis: Effects on regulatory T cells显示文摘 | Julie Rowin Muthusamy Thiruppathi Ebinehita Arhebamen Jianrong Sheng Bellur S. Prabhakar Matthew N. Meriggioli | 2012 | Muscle Nerve2012，，3： | 1 |
| 18 | Validation of the Ox- ford classification of IgA nephropathy in cohorts with dif- ferent presentations and treatments 显示文摘 | Coppo R Troyanov S Bellur S | 2014 | Kidney Int2014，86，4： | 1 |
| 19 | Effect of seven different modalities of antihypertensive therapy on pulse pressure in patients with newly diagnosed stage I hypertension显示文摘 | Alici G Aliyev F Bellur G | 2009 | Cardiovasc Ther2009，27，1： | 1 |
| 20 | Validation of the Oxford classification of IgA nephropathy in cohorts with different presentations and treatments显示文摘 | CoppoR TroyanovS BellurS | 2014 | Kidney Int2014，86，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员