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| 1 | 3种天然抗氧化剂对维生素D_2稳定性的保护作用显示文摘应用超高效液相色谱,分别测定白藜芦醇、茶多酚及大豆异黄酮与维生素D_2在1∶1、1∶10、10∶1这3种质量比例混合下,放置10、26、36 d后样品中维生素D_2稳定性变化。结果表明,以1∶1、1∶10、10∶1质量比例添加的3种天然抗氧化剂均对维生素D_2稳定性具有一定的保护作用,且随着放置时间的延长,对维生素D_2的稳定性保护作用愈明显。其中以1∶10质量比例添加对维生素D_2的稳定性保护作用最佳,添加3种天然抗氧化剂36 d后维生素D_2的存留率均在84%以上,与空白对照相比分别增加72.72%、68.08%、75.32%。茶多酚、大豆异黄酮及白藜芦醇3种天然抗氧化剂均对维生素D_2具有较好的稳定性保护作用,其中以1∶10质量比例混合时效果较佳。 | 胡代花 张嘉昕 韩豪 王永吉 | 2016 | 江苏农业科学2016，44，8： | 1 |
| 2 | Identification, synthesis and characterization of process related desfluoro impurity of ezetimibe and HPLC method validations显示文摘Ezetimibe, which selectively inhibits cholesterol absorption across the intestinal wall and is used as an antihyperlipidemic agent, is synthesized for commercial use as a drug substance in highly pure form.During the synthetic process development studies of ezetimibe, an impurity was detected in the final product at levels ranging from 0.05% to 0.15% in reverse phase gradient high performance liquid chromatography(HPLC) method and its molecular weight was determined by LC–MS analysis. The impurity was identified as(3R,4S)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)-1-phenylazetidin-2-one which is called desfluoro ezetimibe(lactam-related) impurity, synthesized and characterized, the mechanism of its formation was discussed in detail. After all standardization procedures, it was used as a reference standard during validation of HPLC method and routine analyses. In addition,content of Eze-1 desfluoro impurity in Eze-1 intermediates was specified as 0.10% to keep the formation of desfluoro ezetimibe impurity under control and the related substances HPLC method was validated accordingly. | Esen Bellur Atici Bekir Karl??a | 2015 | Journal of Pharmaceutical Analysis2015，5，6： | 0 |
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