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| 1 | Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells显示文摘Liver fibrosis is a consequence of chronic liver disease,causing morbidity and mortality.Interleukin-33(IL-33)is a critical mediator of inflammation,which may be involved in the development of liver fibrosis.Here,we investigated the role of IL-33 in human patients and experimental bile-duct ligation(BDL)-induced fibrosis in mice.We report increased hepatic IL-33 expression in the murine BDL model of fibrosis and in surgical samples obtained from patients with liver fibrosis.Liver injury,inflammatory cell infiltration and fibrosis were reduced in the absence of the IL-33/ST2 receptor,and the activation of hepatic stellate cells(HSCs)was decreased in ST2-deficient mice.Recombinant IL-33 activated HSCs isolated from C57BL/6 mice,leading to the expression of IL-6,TGF-β,α-SMA and collagen,which was abrogated in the absence of ST2 or by pharmacological inhibition of MAPK signaling.Finally,administration of recombinant IL-33 significantly increased hepatic inflammation in sham-operated BL6 mice but did not enhance BDL-induced hepatic inflammation and fibrosis.In conclusion,BDL-induced liver inflammation and fibrosis are dependent on ST2 signaling in HSCs,and therefore,the IL-33/ST2 pathway may be a potential therapeutic target in human patients with chronic hepatitis and liver fibrosis. | Zhongming Tan Qianghui Liu Runqiu Jiang Long Lv Siamak S Shoto Isabelle Maillet Valerie Quesniaux Junwei Tang Wenjie Zhang Beicheng Sun Bernhard Ryffel | 2018 | Cellular & Molecular Immunology2018，15，4： | 24 |
| 2 | Factors influencing the concentration of negative air ions during the year in forests and urban green spaces of the Dapeng Peninsula in Shenzhen, China显示文摘Negative air ions(NAIs)benefit the mental and physical health of humans,but rapid urbanization can decrease the abundance of NAIs.Quantifying the spatial and seasonal distribution of NAIs and determining the factors that infl uence the concentration during urbanization is thus essential.In the present study of a typical developing urban district in southern China,negative air ion concentrations(NAICs)in 60 forests sites and 30 urban green spaces were quantifi ed on seven consecutive days in each of the four seasons.Large seasonal variations in NAIC were revealed in forests and urban green spaces with trough values in summer.NAIC progressively decreased from forests to urban green spaces and was infl uenced by local land morphology,vegetation characteristics,and climatic factors.The vast,heavily vegetated northeastern region was the richest area for NAIs,whereas the narrow central region(urbanized area)was the poorest,implying dramatic impacts of urbanization on the spatial distribution of NAIs.The relationship between air temperature and NAIC was better fi tted with a quadratic equation than a linear equation.Moreover,the NAIC was more sensitive to local morphology in urban green spaces than in urban forests,indicating the vulnerability of NAIs in urbanized areas.Therefore,the appropriate design of local urban morphology is critical. | Yafei Wang Zhuobiao Ni Di Wu Chen Fan Jiaqi Lu Beicheng Xia | 2020 | Journal of Forestry Research2020，31，6： | 11 |
| 3 | Attenuated Listeria monocytogenes as a cancer vaccine vector for the delivery of CD24, a biomarker for hepatic cancer stem cells显示文摘稀释 Listeria monocytogenes (LM ) 是为癌症疫苗的交货的有希望的候选人向量。在由介绍抗原的房间的吞噬作用以后,这个细菌刺激主要 histocompatibility 建筑群(MHC ) 我和 MHC-II 小径并且导致抗原特定的 T 淋巴细胞的增长。包含复制缺乏的 LM 种类 Δ 的基因修正的新策略; dalΔ dat (Lmdd ) 被开发了表示并且藏匿人的 CD24 蛋白质。CD24 是仔细与 hepatocellular 癌(HCC ) 的 apoptosis,转移和复发被联系的肝的癌症干细胞 biomarker。在在老鼠的静脉内的管理以后, Lmdd-CD24 首先在怒气和肝被散布并且没引起严重机关损害。Lmdd-CD24 有效地增加了干扰素(IFN ) 的数字 -γ-producing CD8 + T 房间和 IFN-γ分泌物。Lmdd-CD24 也提高了 IL-4- 和 IL-10-producing T 助手 2 房间的数字。Lmdd-CD24 疫苗的功效进一步对 Hepa1-6-CD24 肿瘤被调查,它腹股沟地被接种进老鼠。Lmdd-CD24 显著地在老鼠减少了肿瘤尺寸并且增加了他们的幸存。尤其是, T 规章的房间(Treg ) 的减小数并且特定的 CD8 +T 房间活动的改进在渗入肿瘤的淋巴细胞(TIL ) 被观察。这些结果对 HCC 建议 Lmdd-CD24 疫苗的一个潜在的应用程序。 | Yu Yang Jiajie Hou Zhe Lin Han Zhuo DianyuChen Xudong Zhang Yun Chen Beicheng Sun | 2014 | Cellular & Molecular Immunology2014，11，2： | 9 |
| 4 | Hydrogeochemical and mineralogical characteristics related to heavy metal attenuation in a stream polluted by acid mine drainage:A case study in Dabaoshan Mine,China显示文摘Dabaoshan Mine,the largest mine in south China,has been developed since the 1970s.Acid mine drainage (AMD) discharged from the mine has caused severe environmental pollution and human health problems.In this article,chemical characteristics,mineralogy of ocher precipitations and heavy metal attenuation in the AMD are discussed based on physicochemical analysis,mineral analysis,sequential extraction experiments and hydrogeochemistry.The AMD chemical characteristics were determined from the initial water composition,water-rock interactions and dissolved sulfide minerals in the mine tailings.The waters,affected and unaffected by AMD,were Ca-SO4 and Ca-HCO3 types,respectively.The affected water had a low pH,high SO42 and high heavy metal content and oxidation as determined by the Fe2+ /Fe3+ couple.Heavy metal and SO42 contents of Hengshi River water decreased,while pH increased,downstream.Schwertmannite was the major mineral at the waste dump,while goethite and quartz were dominant at the tailings dam and streambed.Schwertmannite was transformed into goethite at the tailings dam and streambed.The sulfate ions of the secondary minerals changed from bidentate-to monodentate-complexes downstream.Fe-Mn oxide phases of Zn,Cd and Pb in sediments increased downstream.However,organic matter complexes of Cu in sediments increased further away from the tailings.Fe3+ mineral precipitates and transformations controlled the AMD water chemistry. | Huarong Zhao Beicheng Xia Jianqiao Qin Jiaying Zhang | 2012 | Journal of Environmental Sciences2012，24，6： | 8 |
| 5 | EBV LMP2A-specific T Cell Immune Responses Elicited by Dendritic Cells Loaded with LMP2A Protein显示文摘类型 II Epstein-Barr 病毒(EBV ) 联系了象鼻咽的癌和 non-Hodgkin 的淋巴瘤那样的恶意一致地快速的潜伏的膜 2A (LMP2A ) 蛋白质,它被建议了是为免疫疗法的一个理想的目标。在我们表明了的以前的研究,那使用的 LMP2A 蛋白质装载了树枝状的房间,在身体处理房间的最强大的抗原能得到特定、柔韧的反肿瘤在 vitro 的细胞的有免疫力的反应。在这份报纸,我们进一步调查了反肿瘤免疫者反应的 T 房间侧面。我们发现 LMP2A 特定的 CD4+ 和 CD8+ T 房间能被 LMP2A 蛋白质刺激装载树枝状的房间(DC ) 。Th1 类型免疫者反应在有免疫力的反应是主导的由 LMP2A 特定的 CD4+ T 房间调停了。有效地并且明确地忍受房间的 CD8+ 细胞毒素的 T 房间罐头细胞溶解 LMP2A。CD8+ 细胞毒素的 T 房间能也分泌细胞内部的 IFN- 的高水平,它显示这些房间是 EBV-LMP2A 特定的细胞毒素的 T 房间。总的来说,我们的研究证明了装载 DC 能得到的那 LMP2A 蛋白质是反肿瘤细胞的有免疫力的回答高效地。这研究对表示恶意的 EBV-LMP2A 为基于 DC 的免疫疗法提供一个基本原理。 | Yun Chen Hua Sun Genyan Liu Bing Wang Fang Wang Beicheng Sun Kun Yao | 2009 | Cellular & Molecular Immunology2009，6，4： | 6 |
| 6 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 7 | Fibrosis of corpus cavernosum in animals following cavernous nerve ablation显示文摘t Aim: To investigate alterations of smooth muscle cells and collagen fibers in corpus cavernosum following cavernous neurectomy and its relation to the expression of transforming growth factor-β1 (TGF-β1). Methods: Ten adult male SD rats (neurectomy group) were subject to a bilateral cavernous nerve (CN) resection aseptically under an operating microscope, with 6 sham-operated rats as the control. Fifteen weeks after the operation, the penile specimens were collected and prepared for quantitative-analyzing of ratio of smooth muscle to collagen fibers in corpus cavernosum with confocal microscopy, and for detecting the expression of TGF-β1 by RT-PCR and westernblot.Results: Smooth muscle cells that show red color after fluorescent-labeling with tetramethylrhodamine isothiocyanatephalloidin and collagen fibers that produce green autofluorescence after paraformaldehyde fixation were clearly identified under the confocal microscope. Quantification of fluorescent intensity showed that the ratio of smooth muscle to collagen fibers in corpus cavernosum in neurectomy group was 0.265± 0.125, which was significantly lower than that in sham-operated group (0.760±0.196, P<0.01). RT-PCR and western-blot analyses revealed a significantlyhigher expression of TGF-β1 in the penile tissues of the neurectomy animals than that in sham-operated group.Conclusion: Bilateral ablation of CN can lead to fibrosis of corpus cavernosum, which may be related to an increased expression of TGF-β1 induced by hypoxia in cavernous tissue after denervation. | Wan-LiHu Li-QuanHu jianSong Shi-WenLi Xin-MinZheng BeiCheng Bing-ChunTian | 2004 | Asian Journal of Andrology2004，6，2： | 3 |
| 8 | IL-17A Plays a Critical Role in the Pathogenesis of Liver Fibrosis through Hepatic Stellate Cell Activation显示文摘 | Zhongming Tan Xiaofeng Qian Runqiu Jiang Qianghui Liu Youjing Wang Chen Chen Xuehao Wang Bernhard Ryffel Beicheng Sun | 2013 | The Journal of Immunology2013，，4： | 2 |
| 9 | The BH3-only protein BAD mediates TNFα cytotoxicity despite concurrent activation of IKK and NF-κB in septic shock显示文摘煽动性的 cytokine TNF 在许多煽动性、传染的疾病的病理起一个关键作用。然而,在这些疾病位于 TNF cytotoxicity 下面的机制不完全地被理解。这里,我们报导 pro-apoptotic BCL-2 家庭成员坏调停尽管有在由由得到多重机关的织物损坏并且贡献死亡在在有教养的房间并且在 vivo 导致 apoptosis 的 vitro 的 IKK 和 NF-B 的并发的激活的 TNF cytotoxicity 腐败吃惊。在高剂量, TNF 显著地通过 Src-p190GAP 小径的激活使 RhoA 失去活性,导致巨大的肌动朊压力纤维 destabilization,从细胞骨架由实质的坏版本列在后面到 cytosol。在这个条件下面,激活 IKK 没有通过所有 cytosolic 到 phosphorylate 坏,允许对线粒体不适宜的 non-phosphorylated 的 translocation 触发 apoptosis。Polymicrobial 感染利用象高剂量的 TNF 的一样的机制得到多重机关的联系 apoptosis 的织物损坏。因而,损失坏或坏 pro-apoptotic 活动的消除保护老鼠免受多重机关和还原剂死亡率的织物损坏的伤害。我们的结果支持在的一个模型坏调停尽管有在有教养的哺乳动物的房间并且在的 IKK-NF-B 小径的并发的激活的 TNF cytotoxicity 腐败吃惊。 | Jie Yan Hao Zhang Jialing Xiang Yu Zhao Xiang Yuan Beicheng Sun Anning Lin | 2018 | Cell Research2018，28，7： | 2 |
| 10 | Inflammation and liver tumorigenesis显示文摘Inflammation has been considered as one of the hallmarks of cancer,and chronic hepatitis is a major cause of liver cancer.This review will focus on the pathogenic role of inflammation in hepatocarcinogenesis and will discuss recent advances in understanding the chronic hepatitis-liver cancer link based on hot spots in liver cancer research,including cellular interaction,cytokines,microRNA and stem cells.All of these mechanisms should be taken into consideration because they are crucial for the development of more efficacious therapeutic strategies for preventing and treating human chronic hepatitis and hepatocellular carcinoma. | Beicheng Sun Michael Karin | 2013 | Frontiers of Medicine2013，7，2： | 2 |
| 11 | Assessing high resolution oxidation-reduction potential and soluble reactive phosphorus variation across vertical sediments and water layers in Xinghu Lake:A novel laboratory approach显示文摘To understand the transfer process of soluble reactive phosphorus (SRP) on the lake sediment-water interface in a mesotrophic shallow lake in South China, the SRP concentrations and the oxidation-reduction potential (ORP) across the sediment-water interfaces were continually monitored. Sediment samples were collected from Xinghu Lake in Guangdong Province. The ORP dynamics at different layers of overlying water was similar for six experimental systems, whereas those in porewater were significantly different. The ORP in overlying water was 200-300 mV higher than those in sediments. The oxygen penetration depth ranged from 2 to 10 mm in Xiannu Lake sediments. The variation amplitudes of ORP increased with sediment depth, but the mean ORP values were all about 218 mV. The SRP concentrations in porewater maintained at a low level of about 0.049 mg/L because of high atom ratio of total iron and total manganese to total phosphorus. The SRP concentrations and variation amplitudes in porewater increased with sediment depth. The SRP in overlying water mainly originated from SRP transference of the porewater of middle and bottom sediments (3-15 cm). The ORP variation and SRP transfer in porewater played important roles in changing SRP concentrations. A distinct SRP concentration gradient appeared in overlying water when intense exchange occurred at the sediment-water interface; therefore, it was necessary to monitor the SRP concentration profiles to accurately estimate the internal loading. | Yingzhi Li Beicheng Xia Jiaying Zhang Chuanhong Li Wenzhuan Zhu | 2010 | Journal of Environmental Sciences2010，22，7： | 2 |
| 12 | Urban Ecological Security Assessment and Forecasting, based on a Cellular Automata Model: A Case Study of Guangzhou, China显示文摘 | Gong Jianzhou Liu Yansui Xia Beicheng | 2009 | Ecological Modelling2009，220，24： | 1 |
| 13 | Human health risk from soil heavy metal contamination under different land uses near Dabaoshan Mine, Southern China 显示文摘 | Huarong Zhao Beicheng Xia Chen Fan | 2012 | Science of The Total Environment2012，，417418： | 1 |
| 14 | Human health risk from soil heavy metal contamination under different land uses near Dabaoshan Mine,Southern China显示文摘 | Zhao Huarong Xia Beicheng Fan Chen | 2012 | Science of the Total Environment2012，，： | 1 |
| 15 | Ur- ban ecological security assessment and firecasting, based on a cellular automata model: A case study of Guangzhou 显示文摘 | GONG Jianzhou LIU Yansui XIA Beicheng | 2009 | China Ecological Modelling2009，220，： | 1 |
| 16 | TOX deficiency facilitates the differentiation of IL-17A-producingγδT cells to drive autoimmune hepatitis显示文摘The specification of theαβ/γδlineage and the maturation of medullary thymic epithelial cells(mTECs)coordinate central tolerance to self-antigens.However,the mechanisms underlying this biological process remain poorly clarified.Here,we report that dual-stage loss of TOX in thymocytes hierarchically impaired mTEC maturation,promoted thymic IL-17A-producingγδT-cell(Tγδ17)lineage commitment,and led to the development of fatal autoimmune hepatitis(AIH)via different mechanisms.Transfer ofγδT cells from TOX-deficient mice reproduced AIH.TOX interacted with and stabilized the TCF1 protein to maintain the balance ofγδT-cell development in thymic progenitors,and overexpression of TCF1 normalizedαβ/γδlineage specification and activation.In addition,TOX expression was downregulated inγδT cells from AIH patients and was inversely correlated with the AIH diagnostic score.Our findings suggest multifaceted roles of TOX in autoimmune control involving mTEC and Tγδ17 development and provide a potential diagnostic marker for AIH. | Qifeng He Yijun Lu Wenfang Tian Runqiu Jiang Weiwei Yu Yong Liu Meiling Sun Fei Wang Haitian Zhang Ning Wu Zhongjun Dong Beicheng Sun | 2022 | Cellular & Molecular Immunology2022，19，10： | 1 |
| 17 | Human health risk from soil heavy metal contamination under different land uses near Dabaoshan Mine, Southern China 显示文摘 | ZHAO Huarong XlA Beicheng FAN Chen | 2012 | Sci Total Environ2012，417，： | 1 |
| 18 | Combination of Radiofrequency Ablation with Transarterial Chemoembolization for Hepatocellular Carcinoma: A Meta-Analysis显示文摘 | Shushan Yan Donghua Xu Beicheng Sun | 2012 | Digestive Diseases and Sciences2012，，11： | 1 |
| 19 | MTHFR C677T polymorphism contributes to the risk for gastric cancer显示文摘 | Shushan Yan Donghua Xu Pingping Wang Ping Wang Chengcheng Liu Changjiang Hua Tao Jiang Bin Zhang Zengcai Li Lei Lu Xianzhong Liu Bingji Wang Donghua Zhang Rongsheng Zhang Shaoheng He Beicheng Sun Xuan Wang | 2014 | Tumor Biology2014，，3： | 1 |
| 20 | Human health risk from soil heavy metal contamination under different land uses near Dabaoshan Mine, Southern China显示文摘 | Zhao Huarong Xia Beicheng Fan Chen | 2012 | Science of the Total Environment2012，，： | 1 |
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