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1Effects of antiviral therapy on preventing liver tumorigenesis and hepatocellular carcinoma recurrence显示文摘Chronic hepatitis B virus(HBV)infection is the key driving force of liver disease progression,resulting in the development of hepatic dysfunction,cirrhosis and hepatocellular carcinoma(HCC).The primary aim of therapy is to suppress or eliminate HBV replication to reduce the activity of hepatitis,thus reducing the risk of,or slowing the progression of,liver disease.Nucleos(t)ide analogues(Nucs)may result in rapid suppression of HBV replication with normalization of serum transaminases and restore liver function,thus increasing survival in patients with hepatic decompensation.Long-term Nuc therapy may result in histological improvement or reversal of advanced fibrosis and reduction in disease progression,including the development of HCC.The long-term benefits of a finite course of interferon(IFN)-αtherapy also include a sustained and cumulative response,as well as hepatitis B surface antigen seroclearance and reduction in the development of cirrhosis and/or HCC.Pegylated IFN and newer Nucs may achieve better long-term outcomes because of improved efficacy and a low risk of drug resistance.However,treatment outcomes are still far from satisfactory.Understanding the effects of anti-HBV treatment against HCC incidence and recurrence after hepatectomy or liver transplantation is required for further improvement of outcome.Zhong-Ming Tan Bei-Cheng Sun 2013World Journal of Gastroenterology2013,19,47:22
2补体在肝脏损伤与再生中的作用显示文摘肝脏既是体内的代谢器官,也是一个重要的免疫调节器官。补体系统是肝脏内环境平衡和免疫反应的关键部分,不仅参与了肝损伤的发生也参与了肝脏自我修复的过程,适当的补体激活能够促进肝再生,修复受损肝脏。在肝脏疾病的治疗中,治疗性的补体调节可能是一种合理的、有希望的方法,可以避免进一步的组织破坏,保持补体在增殖区域的有益作用。本文就近年来补体在肝脏损伤与再生中的作用进行综述,为补体的研究提供参考。陈海霞 黄少杰 陈锦仪 梁瑞敏 赵佳鑫 段佳林 王婧雯 2021中南药学2021,19,10:2
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