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您的检索式：作者名="Beichen YU"
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| 1 | Mitochondrial transcription factor?A overexpression and base excision repair deficiency in the inner ear of rats with d‐galactose‐induced aging显示文摘 | YiZhong Yu‐JuanHu BeiChen WeiPeng YuSun YangYang Xue‐YanZhao Guo‐runFan XiangHuang Wei‐JiaKong | 2011 | FEBS Journal2011，，14： | 1 |
| 2 | LncRNA-Airn alleviates acute liver injury by inhibiting hepatocyte apoptosis via the NF-κB signaling pathway显示文摘Acute liver injury is a common and serious syndrome caused by multiple factors and unclear pathogenesis.If the injury persists,liver injury can lead to cirrhosis and liver failure and ultimately results in the development of liver cancer.Emerging evidence has indicated that long noncoding RNAs(lncRNAs)play an important role in the development of liver injury.However,the role of antisense Igf2r RNA(Airn)in acute liver injury and its underlying mechanism remain largely unclear.In this study,we show that Airn is upregulated in liver tissue and primary hepatocytes from an acute liver injury mouse model.Consistently,Airn is also overexpressed in serum samples of patients with acute-on-chronic liver failure and is negatively correlated with the Model for End-Stage Liver Disease(MELD)score.Moreover,gene knockout and rescue assays reveal that Airn alleviates CCl_(4)-induced liver injury by inhibiting hepatocyte apoptosis and oxidative stress in vivo.Further investigation reveals that Airn decreases H_(2)O_(2)-induced hepatocyte apoptosis in vitro.Mechanistically,we reveal that Airn represses CCl_(4)-and H_(2)O_(2)-induced enhancement of phosphorylation of p65 and IκBα,suggesting that Airn inhibits hepatocyte apoptosis by inactivating the NF-κB pathway.In conclusion,our results demonstrate that Airn can alleviate acute liver injury by inhibiting hepatocyte apoptosis via inactivating the NF-κB signaling pathway,and Airn could be a potential biomarker for acute liver injury. | Shuai Shao Yu Zhang Feng Zhou Xiaoxiang Meng Zhenjun Yu Guantong Li Lina Zheng Kun Zhang Yuhan Li Beichen Guo Qi Liu Mengxia Zhang Xiaoxiao Du Wei Hong Tao Han | 2022 | Acta Biochimica et Biophysica Sinica2022，54，11： | 1 |
| 3 | Coal and rock dynamic disaster prevention and control technology in the large mining face of a deep outburst mine显示文摘In this study, we systematically studied the occurrence regularity of in situ stress in the Pingdingshan mine. The critical criterion model of coal-rock destabilization was established based on the theoretical framework of fracture mechanics. Furthermore, we analyzed the coupling destabilization mechanism of in situ stress and gas and studied the influence of the variation between original rock stress and mining-induced stress on the critical criterion. Through field experiments and applications, we established a three-dimensional gas drainage technology system for areas with a large mining height and long work face. Based on our research, a demonstration project was developed for deep mine dynamic disaster control. The technical system included the arrangement and optimization of pre-drainage holes along the coal seam, technology, and optimization of gas drainage through the bottom drainage tunnel and upper corner, gas drainage technology through sieve tubes, and a two plugging with one injection under pressure sealing technology. The implementation of the demonstration project effectively reduced the gas content and pressure of the coal seam in the deep mine, and the project increased the critical strength of the instability and failure of coal and rock. | Jianguo ZHANG Man WANG Hongwei ZHOU Dongming ZHANG Beichen YU Chongyang WANG Yujie WANG | 2023 | Frontiers of Earth Science2023，17，3： | 0 |
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