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| 1 | Transient elastography compared to liver biopsy and morphometry for predicting fibrosis in pediatric chronic liver disease: Does etiology matter?显示文摘AIM: To evaluate transient elastography(TE) as a noninvasive tool in staging liver fibrosis compared with liver biopsy and morphometry in children with different chronic liver diseases.METHODS: A total of 90 children [50 with chronic hepatitis C virus(HCV), 20 with autoimmune hepatitis(AIH) and 20 with Wilson disease] were included in the study and underwent liver stiffness measurement(LSM) using TE. Liver biopsies were evaluated for fibrosis, qualitatively, by Ishak score and quantitatively by fibrosis area fraction(FAF) using digital image analysis(morphometry). LSM was correlated with fibrosis and other studied variables using spearman correlation. A stepwise multiple regression analysis was alsoperformed to examine independent factors associated with LSM. Different cut-off values of LSM were calculated for predicting individual fibrosis stages using receiveroperating characteristic curve. Cut-off values with optimal clinical performance(optimal sensitivity and specificity simultaneously) were selected.RESULTS: The majority of HCV group had minimal activity(80%) and no/mild fibrosis(72%). On the other hand, the majority of AIH group had mild to moderate activity(70%) and moderate to severe fibrosis(95%) and all Wilson disease group had mild to moderate activity(100%) and moderate to severe fibrosis(100%). LSM correlated significantly with both FAF and Ishak scores and the correlation appeared better with the latter(r = 0.839 vs 0.879, P < 0.0001 for both). LSM discriminated individual stages of fibrosis with high performance. Sensitivity ranged from 81.4% to 100% and specificity ranged from 75.0% to 97.2%. When we compared LSM values for the same stage of fibrosis, they varied according to the different etiologies. Higher values were in AIH(16.15 ± 7.23 k Pa) compared to Wilson disease(8.30 ± 0.84 k Pa) and HCV groups(7.43 ± 1.73 k Pa). Multiple regression analysis revealed that Ishak fibrosis stage was the only independent variable associated with higher LSM(P < 0.0001).CONCLUSION: TE appears reliable in distinguishing different stages of liver fibrosis in children. However, its values vary according to the disease type. For that, a disease-specific estimation of cut-off values for fibrosis staging is worthy. | Behairy El-Sayed Behairy Mostafa Mohamed Sira Khaled Refat Zalata El-Sayed Ebrahem Salama Mohamed Ahmed Abd-Allah | 2016 | World Journal of Gastroenterology2016，22，16： | 6 |
| 2 | Serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C显示文摘AIM:To evaluate serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C virus(HCV)infection.METHODS:The study included 30 children with chronic HCV infection before receiving antiviral therapy.Chronic HCV infection was defined by positive anti-HCV,a positive polymerase chain reaction for HCV-RNA for more than 6 mo with absence of any associated liver disease.A second group of 30 age-and sex-matched healthy children served as controls.Serum C4a levels were measured by enzyme-linked immunosorbent assay.Liver fibrosis stage and inflammatory grade were assessed using Ishak scoring system.Serum C4a levels were compared according to different clinical,laboratory and histopathological parameters.Statistical significance for quantitative data was tested by MannWhitney U non-parametric tests.For qualitative data,significance between groups was tested by 2test.Correlation was tested by Spearman’s test.Results were considered significant if P value≤0.05.RESULTS:The age of the patients ranged from 3.5to 18 years and that of controls ranged from 4 to 17years.C4a mean levels were merely lower in patients(153.67±18.69 mg/L)than that in the controls(157.25±11.40 mg/L)with no statistical significance(P=0.378).It did not differ significantly in patients with elevated vs those with normal transaminases(152.25±16.62 vs 155.36±21.33;P=0.868)or with different HCV viremia(P=0.561).Furthermore,there was no statistical significant difference in serum levels between those with no/mild fibrosis and those with moderate fibrosis(154.65±20.59 vs 152.97±17.72;P=0.786)or minimal and mild activity(155.1±21.93 vs 152.99±17.43;P=0.809).Though statistically not significant,C4a was highest in fibrosis score 0(F0),decreasing in F1 and F2 to be the lowest in F3.When comparing significant fibrosis(Ishak score≥3)vs other stages,C4a was significantly lower in F3 compared to other fibrosis scores(143.55±2.33 mg/L vs 155.26±19.64 mg/L;P=0.047)and at a cutoff value of less than 144.01 mg/L,C4a could discriminate F3 with 76.9%sensitivity and75%specificity from other stages of fibrosis.CONCLUSION:Serum complement C4a did not correlate with any of transaminases,HCV viremia or with the histopathological scores.Although C4a decreased with higher stages of fibrosis,this change was not significant enough to predict individual stages of fibrosis.Yet,it could predict significant fibrosis with acceptable clinical performance. | Behairy E Behairy Ghada M El-Mashad Ragab S Abd-Elghany Enas M Ghoneim Mostafa M Sira | 2013 | World Journal of Hepatology2013，5，8： | 4 |
| 3 | Serum Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 (ITIH4) in Children with Chronic Hepatitis C: Relation to Liver Fibrosis and Viremia显示文摘 | Mostafa M. Sira Behairy E. Behairy Azza M. Abd-Elaziz Sameh A. Abd Elnaby Ehab E. Eltahan Piero Luigi Almasio | 2014 | Hepatitis Research and Treatment2014，，： | 2 |
| 4 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 5 | Parallel concatenated gallagercodes显示文摘 | BEHAIRY H CHANG S | 2000 | Electron Letters2000，36，24： | 1 |
| 6 | Parallel concatenated gallager codes 显示文摘 | Behairy H Chang S C | 2000 | Electron Letter2000，36，24： | 1 |
| 7 | Parallel Concatenated Gallagher Codes显示文摘 | Behairy H Chang S C | 2000 | Electronics Letters2000，36，24： | 1 |
| 8 | Analysis and design of parallel concatenated Gallager codes 显示文摘 | Behairy H Chang S-C | 2002 | Electronics Letters (S0013-5194)2002，38，18： | 1 |
| 9 | Effect of intercropping patterns on soybeangrowth and photosynthetic apparatus 显示文摘 | Behairy T G | 1994 | Journal of PhysiologicalSciences1994，18，1： | 1 |
| 10 | Parallel Concatenated Gallagher Codes显示文摘 | Behairy H Chang S C | 2000 | Electronics Letters2000，36，24： | 1 |
| 11 | Oxidative stress during erythropoietin hyporesponsiveness anemia at end stage renal disease:Molecular and biochemical studies显示文摘 | Khalil SK Amer HA El Behairy AM | 2016 | J Adv Res2016，7，3： | 1 |
| 12 | Mobile Learning: Taking Education to a New Level显示文摘 | NoufHamid Al Behairi | 2016 | Sino-US English Teaching2016，13，7： | 1 |
| 13 | Parallel concatenated gallager codes显示文摘 | BEHAIRY H CHANG S | 2000 | Electron Letter2000，36，24： | 1 |
| 14 | Growth and chemical composition of grape transplants as affected by some irrigation regimes显示文摘 | Shawky I Rawash MA Behairy Z | 1997 | Acta Horticulturae1997，441，： | 1 |
| 15 | Serological Survey of Dogs From Egypt for Antibodies to Leishmania Species显示文摘 | Rosypal Alexa C Bowman Shanae S Epps Samuel A El Behairy A M Hilali M Dubey J P | 2013 | The Journal of Parasitology2013，，1： | 1 |
| 16 | Parallel Concatenated Gallagher Codes显示文摘 | Chang S C | 2000 | Electronics Letters2000，36，24： | 1 |
| 17 | Removal of internal fixation in pediatric patients显示文摘 | Alzahrani AG Behairy YM Alhossan MH | 2003 | Saudi Med J2003，24，3： | 1 |
| 18 | Parallel concatenated Gallager codes显示文摘 | Behairy H Chang S C | 2000 | Electronics letters2000，36，24： | 1 |
| 19 | Accuracy of routine magnetic resonance imaging in meniseal and ligamentous injuries of the knee : comparison with arthroscopy显示文摘 | Behairy NH Dorgham MA Khaled SA | 2009 | Int Orthop2009，33，4： | 1 |
| 20 | All-trans-retinoic acid modulates nitric oxide and interleukin-17A production by peripheral blood mononuclear cells from patients with Alzheimer’s disease显示文摘 | Behairi N Belkhelfa M Mesbah-Amroun H | 2015 | Neuroimmunomodulation2015，22，： | 1 |
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