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| 1 | Peritoneal carcinomatosis of colorectal origin:Incidence,prognosis and treatment options显示文摘Peritoneal carcinomatosis (PC) is one manifestation of metastatic colorectal cancer (CRC). Tumor growth on intestinal surfaces and associated fluid accumulation eventually result in bowel obstruction and incapacitating levels of ascites, which profoundly affect the quality of life for affected patients. PC appears resistant to traditional 5-fluorouracil-based chemotherapy, and surgery was formerly reserved for palliative purposes only. In the absence of effective treatment, the histori-cal prognosis for these patients was extremely poor, with an invariably fatal outcome. These poor outcomes likely explain why PC secondary to CRC has received little attention from oncologic researchers. Thus, data are lacking regarding incidence, clinical disease course, and accurate treatment evaluation for patients with PC. Recently, population-based studies have revealed that PC occurs relatively frequently among patients withCRC. Risk factors for developing PC have been identi-fied:right-sided tumor, advanced T-stage, advanced N-stage, poor differentiation grade, and younger age at diagnosis. During the past decade, both chemother-apeutical and surgical treatments have achieved prom-ising results in these patients. A chance for long-term survival or even cure may now be offered to selected patients by combining radical surgical resection with intraperitoneal instillation of heated chemotherapy. This combined procedure has become known as hy-perthermic intraperitoneal chemotherapy. This edito-rial outlines recent advancements in the medical and surgical treatment of PC and reviews the most recent information on incidence and prognosis of this disease. Given recent progress, treatment should now be considered in every patient presenting with PC. | Yvonne LB Klaver Valery EPP Lemmens Simon W Nienhuijs Misha DP Luyer Ignace HJT de Hingh | 2012 | World Journal of Gastroenterology2012，18，39： | 9 |
| 2 | Interprofessional, multiple step simulation course improves pediatric resident and nursing staff management of pediatric patients with diabetic ketoacidosis显示文摘AIM To investigate the use of a multidisciplinary, longitudinal simulation to educate pediatric residents and nurses on management of pediatric diabetic ketoacidosis.METHODS A multidisciplinary, multiple step simulation course was developed by faculty and staff using a modified Delphi method from the Pediatric Simulation Center and pediatric endocrinology department. Effectiveness of the simulation for the residents was measured with a pre- and post-test and a reference group not exposed to simulation. A follow up post-test was completed 3-6 mo after the simulation. Nurses completed a survey regarding the education activity. RESULTS Pediatric and medicine-pediatric residents(n = 20) and pediatric nurses(n = 25) completed the simulation course. Graduating residents(n = 16) were used as reference group. Pretest results were similar in the control and intervention group(74% ± 10% vs 76% ± 15%, P = 0.658). After completing the intervention, participants improved in the immediate post-test in comparison to themselves and the control group(84% ± 12% post study; P < 0.05). The 3-6 mo follow up post-test results demonstrated knowledge decay when compared to their immediate post-test results(78% ± 14%, P = 0.761). Residents and nurses felt the interdisciplinary and longitudinal nature of the simulation helped with learning.CONCLUSION Results suggest a multidisciplinary, longitudinal simulation improves immediate post-intervention knowledge but important knowledge decay occurs, future studies are needed to determine ways to decrease this decay. | Linnea M Larson-Williams Amber Q Youngblood Dawn Taylor Peterson J Lynn Zinkan Marjorie L White Hussein Abdul-Latif Leen Matalka Stephen N Epps Nancy M Tofil | 2016 | World Journal of Critical Care Medicine2016，5，4： | 4 |
| 3 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 4 | Human memory cytotoxic T-lymphocyte(CTL)responses to Hantaan virus infection:identification of virus-specific and cross-reactive CD8(+)CTL epitopes on mucleocapsid protein显示文摘 | Van Epps H L Schmaljohn C S Ennis F A | 1999 | J Virol1999，73，7： | 2 |
| 5 | Kinetics and inhibition of lipid exchange catalyzed by plasma cholesteryl ester transfer protein (lipid transfer protein) 显示文摘 | Epps DE Greenlee KA Harris JS | 1995 | Biochemistry1995，34，12： | 2 |
| 6 | Deformation behavior of spray-formed hypereutectic Al–Si alloys显示文摘 | C. Cui A. Schulz J. Epp H. W. Zoch | 2010 | Journal of Materials Science2010，，10： | 2 |
| 7 | Human memory cytotoxic T- lymphocyte (CTL) responses to Hantaan virus infection: Indentification of virus-specfic and cross-reactive CD8+ CTL epitopes on nucleocapsid protein 显示文摘 | Schmaljohn CS Ennis FA | 1999 | J Virol1999，73，7： | 1 |
| 8 | Neurotrophins and electrical stimulation for protection and repair of spiral ganglion neurons following sensorineural hearing loss显示文摘 | Shepherd RK Coco A Epp SB | 2008 | Hear Res2008，242，： | 1 |
| 9 | Co-movements in stock prices in the very short run显示文摘 | Epps T W | 1979 | Journal of the American Statistical Association1979，74，366： | 1 |
| 10 | Using video - facilitated feedback to improve student performance following high - fidelity simulation 显示文摘 | Grant S Moss J Epps C | 2010 | Clin Simul in Nurs2010，6，5： | 1 |
| 11 | Research management team(RMT) : A model for research support -services at Duke Univelity显示文摘 | Snyder D C Epps S Berestbrd H F el al | 2012 | Clinical and Translational Science2012，5，6： | 1 |
| 12 | Familiy Identity:A Framework of Identity Interplay in Consumption Pratices显示文摘 | Epp A M | 2008 | Journal of Consumer Research2008，35，1： | 1 |
| 13 | Comovements in stock prices in the very short run显示文摘 | Epps T W | 1979 | Journal of the American Statistical Asso- ciation1979，74，366： | 1 |
| 14 | Interfacial manipulations:Controlling nanoscale assembly in bulk,thin film,and solution block copolymer systems显示文摘 | Mastroianni S E Epps T H | 2013 | Langmuir2013，29，12： | 1 |
| 15 | What school children need to learn about injury prevention?显示文摘 | Bass JL Mehta KA Eppes BM | 1989 | Public Health Rep1989，104，： | 1 |
| 16 | Long- lived Memory T Lymphocyte Responses Afte Hantavirus Infection 显示文摘 | Van Epps HL Masanori Terajima Jukka Mustonen | 2002 | Exp Med2002，196，5： | 1 |
| 17 | Shape memory alloy actuation for active tuning of composite beams显示文摘 | Epps J Chandra R | 1997 | Smart Mater Struct1997，6，： | 1 |
| 18 | Two types of anthracnose resistance in cucumbers显示文摘 | Barnes W C Epps W M | 1952 | Plant Disease Reporter1952，36，： | 1 |
| 19 | Evaluation of Brassica rapa L. genotypes for microspore culture response and identification of a highly embryogenic line显示文摘 | A. M. R. Ferrie D. J. Epp W. A. Keller | 1995 | Plant Cell Reports1995，，9： | 1 |
| 20 | L-Proline Functional- ized Polymers Prepared by RAFT Polymerization and Their Assemblies as Supported Organoeatalysts显示文摘 | Lu A Smart T P Epps T H | 2011 | Mac- romo12011，44，18： | 1 |
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