|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | Outcome in obscure gastrointestinal bleeding after capsule endoscopy显示文摘AIM: To investigate the clinical impact of capsule endoscopy(CE) after an obscure gastrointestinal bleeding(OGIB) episode, focusing on diagnostic work-up, followup and predictive factors of rebleeding. METHODS: Patients who were referred to Hospital del Mar(Barcelona, Spain) between 2007 and 2009 for OGIB who underwent a CE were retrospectively analyzed. Demographic data, current treatment with non-steroid antiinflammtory drugs or anticoagulant drugs, hemoglobin levels, transfusion requirements, previous diagnostic tests for the bleeding episode, as well as CE findings(significant or non-significant), work-up and patient out-comes were analyzed from electronic charts. Variables were compared by χ 2 analysis and Student t test. Risk factors of rebleeding were assessed by Log-rank test, Kaplan-Meier curves and Cox regression model. RESULTS: There were 105 patients [45.7% women, median age of 72 years old(interquartile range 56-79)] and a median follow-up of 326 d(interquartile range 123-641) included in this study. The overall diagnostic yield of CE was 58.1%(55.2% and 63.2%, for patients with occult OGIB and overt OGIB, respectively). In 73 patients(69.5%), OGIB was resolved. Multivariate analysis showed that hemoglobin levels lower than 8 g/dL at diagnosis [hazard ratios(HR) = 2.7, 95%CI: 1.9-6.3], patients aged 70 years and above(HR = 2.1, 95%CI: 1.2-6.1) and significant findings in CE(HR = 2.4, 95%CI: 1.1-5.8) were independent predictors of rebleeding. CONCLUSION: One third of the patients presented with rebleeding after CE; risk factors were hemoglobin levels < 8 g/dL, age ≥ 70 years or the presence of significant lesions. | Alex Caas-Ventura Lucia Márque Xavier Bessa Josep Maria DedeuDepartment of Gastroenterology Hospital del Mar Research Institute Pompeu Fabra University Marc Puigvehí Sílvia Delgado-Aros Ines Ana Ibáez Agustin Seoane Luis Barranco Felipe Bory Montserrat Andreu Begoa González-Suárez | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 4 |
| 3 | Lack of microRNA‐101 causes E‐cadherin functional deregulation through EZH2 up‐regulation in intestinal gastric cancer显示文摘 | Joana Carvalho Nicole C van Grieken Patricia M Pereira Sónia Sousa Marianne Tijssen Tineke E Buffart Bego?a Diosdado Heike Grabsch Manuel AS Santos Gerrit Meijer Raquel Seruca Beatriz Carvalho Carla Oliveira | 2012 | J Pathol2012，，1： | 3 |
| 4 | Field-amplified sample stacking for the detection of chemical warfare agent degradation products in low-conductivity matrices by capillary electrophoresis-mass spectrometry显示文摘 | Lagarrigue M Bossee A Begos A Delannay N | 2008 | Journal of Chromatography A2008，，1178： | 1 |
| 5 | Characterization of an antisense transcript spanning the UL81 82 locus of human cytomegalovirus显示文摘 | Bego M Maciejewski J Khaihoullina S | 2005 | J Virol2005，79，11： | 1 |
| 6 | Laparoscopic cholecystectomy: from gimmick to gold standard显示文摘 | Begos D G Modlin I M | 1994 | J Clin Gastroenterol1994，19，4： | 1 |
| 7 | The diagnosis and management of adult intussusception显示文摘 | Begos DG Sandor A Modlini M | 1997 | Am J Surg1997，173，1： | 1 |
| 8 | Effect of the packaging method and the storage time on lipid oxidation and colour stability on dry fermented sausage salchichón manufactured with raw material with a high level of mono and polyunsaturated fatty acids显示文摘 | Bego?a Rubio Beatriz Martínez M a Dolores García-Cachán Jordi Rovira Isabel Jaime | 2008 | Meat Science2008，，4： | 1 |
| 9 | Modulation of HIV- 1 host interaction: role of the Vpu accessory protein 显示文摘 | Dub M Bego MG Paquay C etal | 2010 | Retrovirology2010，7，： | 1 |
| 10 | The diagnosis and management of aciite intussusception显示文摘 | Begos D G Sandor A Modlin I M | 1997 | Gastrointest Endoscop1997，173，： | 1 |
| 11 | Selective extraction of organophosphorus nerve agent degradation products by molecularly imprinted solid-phase extraction 显示文摘 | Le M S Begos A Pichon V | 2006 | Journal of Chromatography A2006，1108，1： | 1 |
| 12 | The diagnosis and manage- ment of adult intussusception 显示文摘 | Begos D G Sandor A Modlin 1 M | 1997 | American Journal of SurgeL''y1997，173，2： | 1 |
| 13 | Modulation of HIV-1-host interaction:role of the Vpu accessory protein显示文摘 | DubéM Bego MG Paquay C | 2010 | Retrovirology2010，7，1： | 1 |
| 14 | Identification of novel antihypertensive peptides in milk fermented with enterococcus faecalis显示文摘 | Ana Q Mercedes R Bego(n)a M | 2007 | International Dairy Joumal2007，17，1： | 1 |
| 15 | Lack of microRNA‐101 causes E‐cadherin functional deregulation through EZH2 up‐regulation in intestinal gastric cancer显示文摘 | Joana Carvalho Nicole C van Grieken Patricia M Pereira Sónia Sousa Marianne Tijssen Tineke E Buffart Bego?a Diosdado Heike Grabsch Manuel AS Santos Gerrit Meijer Raquel Seruca Beatriz Carvalho Carla Oliveira | 2012 | J Pathol2012，，1： | 1 |
| 16 | The diagnosis and management of adult intussusception 显示文摘 | Begos D G Sandor A Modlin I M | 1997 | Am J Surg1997，173，2： | 1 |
| 17 | The diagnosisand management of adult intussuseeption 显示文摘 | Begos DG Sandor A Modlin M | 1997 | Am J Surg1997，173，： | 1 |
| 18 | Natural antioxidants against lipid- protein oxidative deterioration in meat and meat products显示文摘 | Nuria S Bego a V Berta B Marco M | 2012 | Talanta2012，89，30： | 1 |
| 19 | Mesenehymal stem cells engineered to inhibit complement-mediated damage 显示文摘 | Soland MA Bego M Colletti E | 2013 | PLoS One2013，8，60： | 1 |
| 20 | An overlooked DNA source for non‐invasive genetic analysis in birds显示文摘 | Márton B. Horváth Bego?a Martínez‐Cruz Juan J. Negro Lajos Kalmár José A. Godoy | 2005 | Journal of Avian Biology2005，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员