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| 1 | Computed tomography-guided percutaneous core needle biopsy in pancreatic tumor diagnosis显示文摘AIM: To evaluate the techniques, results, and complications related to computed tomography(CT)-guided percutaneous core needle biopsies of solid pancreatic lesions.METHODS: CT-guided percutaneous biopsies of solid pancreatic lesions performed at a cancer reference center between January 2012 and September 2013 were retrospectively analyzed. Biopsy material was collected with a 16-20 G Tru-Core needle(10-15 cm; Angiotech, Vancouver, CA) using a coaxial system and automatic biopsy gun. When direct access to the lesion was not possible, indirect(transgastric or transhepatic) access or hydrodissection and/or pneumodissection maneuvers were used. Characteristics of the patients, lesions, procedures, and histologic results were recorded using a standardized form. RESULTS: A total of 103 procedures included in the study were performed on patients with a mean age of 64.8 year(range: 39-94 year). The mean size of the pancreatic lesions was 45.5 mm(range: 15-195 mm). Most(75/103, 72.8%) procedures were performed via direct access, though hydrodissection and/or pneumodissection were used in 22.2%(23/103) of cases and indirect transhepatic or transgastric access was used in 4.8%(5/103) of cases. Histologic analysis was performed on all biopsies, and diagnoses were conclusive in 98.1%(101/103) of cases, confirming3.9%(4/103) of tumors were benign and 94.2%(97/103) were malignant; results were atypical in 1.9%(2/103) of cases, requiring a repeat biopsy to diagnose a neuroendocrine tumor, and surgical resection to confirm a primary adenocarcinoma. Only mild/moderate complications were observed in 9/103 patients(8.7%),and they were more commonly associated with biopsies of lesions located in the head/uncinate process(n =8), than of those located in the body/tail(n = 1) of the pancreas, but this difference was not significant.CONCLUSION: CT-guided biopsy of a pancreatic lesion is a safe procedure with a high success rate, and is an excellent option for minimally invasive diagnosis. | Chiang J Tyng Maria Fernanda A Almeida Paula NV Barbosa Almir GV Bitencourt José Augusto AG Berg Macello S Maciel Felipe JF Coimbra Luiz Henrique O Schiavon Maria Dirlei Begnami Marcos D Guimares Charles E Zurstrassen Rubens Chojniak | 2015 | World Journal of Gastroenterology2015，21，12： | 14 |
| 2 | Differential expression of apoptosis related proteins and nitric oxide synthases in Epstein Barr associated gastric carcinomas显示文摘瞄准:为了决定 Epstein Barr 的发生,病毒在巴西联系了胃的癌(GC ) 并且比较 apoptosis 的表情在 EBV 之间的相关蛋白质和氮的氧化物 synthases 积极、否定的胃的癌。方法:编码 EBV 的小 RNA-1 (EBER-1 ) 和 PCR 的原位杂交被执行在 GC 识别 EBV 的存在。Immunohistochemistry 被用来在 25 EBV 积极 GC 并且在 103 EBV 否定 GCS 识别 bcl-2, bcl-xl, bak, bax, p53, NOS-1, NOS-2,和 NOS-3 蛋白质的表情。结果:GC (25/208 ) 的 12% 盒子显示出 EBER-1 和 EBNA-1 表示。盒子是优先地 diffuse 打字与强烈淋巴在基质渗入。EBV 联系了 GC bcl-2 蛋白质的显示出的更高的表示和 bak 蛋白质的更低的表示与比在 EBV 否定 GC。确实, NOS-1 和 NOS-3 的表情经常在 EBV 被观察联系 GC。结论:我们的数据建议 EBV 感染可以保护肿瘤房间免受 apoptosis 的伤害,为永久房间骑车和增长给他们能力。另外, EBV 积极 GC 显示出能影响肿瘤前进和攻击性的组成的 NOS 的高表示。 | Maria D Begnami Andre L Montagnini Andre L Vettore Sueli Nonogaki Mariana Brait Alex Y Simoes-Sato Andrea Q A Seixas Fernando A Soares | 2006 | World Journal of Gastroenterology2006，12，31： | 5 |
| 3 | The influence of transforming growth factor‐α, cyclooxygenase‐2, matrix metalloproteinase (MMP)‐7, MMP‐9 and CXCR4 proteins involved in epithelial–mesenchymal transition on overall survival of patients with gastric cancer显示文摘 | Marcello Ferretti Fanelli Ludmilla T Domingos Chinen Maria Dirlei Begnami Wilson Luis Costa José Humberto T Fregnami Fernando A Soares André Luis Montagnini | 2012 | Histopathology2012，，2： | 2 |
| 4 | Cellular alterations during accelerated aging of French bean seeds显示文摘 | BEGNAMI C N CORTELAZZO A L | 1997 | Seed Science and Technolo- gy1997，24，： | 1 |
| 5 | Prognostic impli- cations of altered human epidermal growth factor receptors (HERs) in gastric carcinomas: HER2 and HER3 are predictors of poor outcome显示文摘 | Begnami MD Fukuda E Fregnani JH | 2011 | J Clin Oncol2011，29，22： | 1 |
| 6 | Evaluation of cell cycle protein expression in gastric cancer: cyclin B1 expression and its prognostic implication显示文摘 | Begnami MD Fregnani J H Nonogaki S | 2010 | Hum Pathol2010，41，8： | 1 |
| 7 | The influence of transforming growth factor-a, cyclooxygenase-2, matrix metalloprot- einase (MMP)-7, MMP-9 and CXCR4 proteins involved in epithelia- l-mesenchymal transition on overall survival of patients with gastric cancer显示文摘 | Fanelli MF Chinen LT Begnami MD | 2012 | Histopathology2012，61，2： | 1 |
| 8 | Prognostic implica- tions of altered human epidermal growth factor receptors (HERs) in gastric carcinomas:HER2 and HER3 are predictors of poor outcome显示文摘 | Begnami MD Fukuda E Fregnani JH | 2011 | J Clin Oneol2011，29，22： | 1 |
| 9 | Prognostic implica- tions of altered human epidermal growth factor receptors (HERs) in gastric carcinomas: HER2 and HER3 are predictors of poor outcome显示文摘 | Begnami MD Fukuda E Fregnani JH | 2011 | J Clin Oncol2011，29，22： | 1 |
| 10 | Evaluation of RB gene and cyclin-dependent kinase inhibitors p21 and p27 in pleomorphic xantoastrocytoma 显示文摘 | Begnami MD Rushing E J Evangelista R | 2006 | Int J Surg Pathol2006，14，2： | 1 |
| 11 | Prognostic im- plications of altered human eoidermal growth factor receptors (HERs) in gastric carcinomas; HER2 and HER3 are predic- tors of poor outcome显示文摘 | Begnami M D Fukuda E Fregnani J H | 2011 | J Clin Oncol2011，29，22： | 1 |
| 12 | Evaluation of cell cycle protein expression in gastric cancer:Cyclin B1 expression and its prognostic implication显示文摘 | Begnami M D Fregnani J H Nonogaki S | 2010 | Hum Pathol2010，41，8： | 1 |
| 13 | Prognostic implications of altered human epidermal growth factor receptors (HERs) in gastric careinomas: HER2 and HER3 are predictors of poor outcome显示文摘 | Begnami MD Fukuda E Fregnani JH | 2011 | Clin Oncol2011，29，8： | 1 |
| 14 | Evaluation of cell cycle protein expression in gastric cancer:cyclin B1 expression and its prognostic implication显示文摘 | Begnami MD Fregnani JH Nonogaki S Soares FA | | 0，，08： | 1 |
| 15 | The interaction between N-category and N-ratio as a new tool to improve lymph node metastasis staging in gastric cancer: Results of a single cancer center in Brazil显示文摘 | F.J.F. Coimbra W.L. Costa A.L. Montagnini A.L. Diniz H.S.C. Ribeiro M.J.B. Silva M.F.S. Begnami | 2010 | European Journal of Surgical Oncology2010，，1： | 1 |
| 16 | Adenoid cystic/basalcell carcinoma of the prostate:review and update显示文摘 | Begnami MD Quezado M Pinto P | 2007 | Arch Pathol Lab Med2007，131，4： | 1 |
| 17 | Prognostic implications of altered human epidermal growth factor receptors(HERs) in gastric carcinomas:HER2 and HER3 are predictors of poor outcome显示文摘 | Begnami MD Fukuda E Fregnani JH | | 0，，22： | 1 |
| 18 | Prognostic implications of altered human epidermal growth factor receptors (HERs) in gastric carcinomas:HER2 and HER3 are predictors of poor outcome显示文摘 | Begnami MD Fukuda E Fregnani JH | 2011 | J Clin Oncol2011，29，22： | 1 |
| 19 | Cellular alterations during aceel- eratedaging of French bean seeds 显示文摘 | Begnami C N Cortelazzo A L | 1996 | Seed Science and Technology1996，24，： | 1 |
| 20 | Prognostic implications of altered human epidermal growth factor Receptors (HERs) in gastric carcinomas: HER2 and HER3 are predictors of poor outeome显示文摘 | Begnami MD Fukuda E Fregnani JH | 2011 | J Clin Oncol2011，29，22： | 1 |
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