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| 1 | Infectious diseases in the aftermath of monsoon flooding in Pakistan显示文摘Pakistan is ranked 9th in terms of flood-affected countries worldwide.In the summer of 2010,the northern province of Khyber-Pakhtunkhwa received more than 312 mm of rain in a 56 hour period.This resulted in over 1 600 deaths across the region.In addition,over 14 million people were directly affected by this record-breaking deluge.Flood affected regions serve as ideal breeding grounds for pathogens,leading to the spread of diseases.The poor standards of hygiene in camps set up for individuals displaced by the floods also contribute to this.It is essential that those involved in relief efforts are aware of the epidemiology of diseases that have historically seen a sudden upsurge after natural disasters.Keeping this in mind,we conducted a simple review of literature.An extensive literature search was conducted using the PubMed data base and online search engines.Articles published in the last 20 years were considered along with some historical articles where a background was required.Seven major diseases were identified to increase substantially in the aftermath of natural disasters.They were then classified into acute and sub-acute settings.Diarrhea,skin&eye infections and leptospirosis were identified in the acute setting while malaria,leishmaniasis,respiratory infections and hepatitis were identified in the sub-acute setting. | Maryam Baqir Zain A Sobani Amyn Bhamani Nida Shahab Bham Sidra Abid Javeria Farook M Asim Beg | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，1： | 2 |
| 2 | Role of PTPN2/22 polymorphisms in pathophysiology of Crohn's disease显示文摘AIM To establish the relationship of protein tyrosine phosphatase non-receptor type 2 and 22(PTPN2/22) polymorphisms and mycobacterial infections in Crohn's disease(CD). METHODS All 133 subjects' blood samples were genotyped for nine single nucleotide polymorphisms(SNPs) in PTPN2/22 using TaqMan^(?) genotyping, while the effect of the SNPs on PTPN2/22 and IFN-γ gene expression was determined using RT-PCR. Detection of Mycobacterium avium subspecies paratuberculosis(MAP) IS900 gene was done by nPCR after DNA extraction from the isolated leukocytes of each subjects' blood samples. T-cells isolated from the patient samples were tested for response to phytohematoagglutonin(PHA) mitogen or mycobacterial antigens by Brd U proliferation assays for T-cell activity. RESULTS Out of the nine SNPs examined, subjects with either heterozygous(TC)/minor(CC) alleles in PTPN2:rs478582 occurred in 83% of CD subjects compared to 61% healthy controls(P-values < 0.05; OR = 3.03). Subjects with either heterozygous(GA)/minor(AA) alleles in PTPN22:rs2476601 occurred in 16% of CD compared to 6% healthy controls(OR = 2.7). Gene expression in PTPN2/22 in CD subjects was significantly decreased by 2 folds compared to healthy controls(P-values < 0.05). IFN-γ expression levels were found to be significantly increased by approxiately 2 folds in subjects when either heterozygous or minor alleles in PTPN2:rs478582 and/or PTPN22:rs2476601 were found(P-values < 0.05). MAP DNA was detected in 61% of CD compared to only 8% of healthy controls(P-values < 0.05, OR = 17.52), where subjects with either heterozygous or minor alleles in PTPN2:rs478582 and/or PTPN22:rs2476601 had more MAPbacteremia presence than subjects without SNPs did. T h e average T-cell proliferation in CD treated with PHA or mycobacteria antigens was, respectively, 1.3 folds and 1.5 folds higher than healthy controls without any significant SNP. CONCLUSION The data suggests that SNPs in PTPN2/22 affect the negative regulation of the immune response in CD patients, thus leading to an increase in inflammation/apoptosis and susceptibility of mycobacteria. | Robert C Sharp Shazia A Beg Saleh A Naser | 2018 | World Journal of Gastroenterology2018，24，6： | 2 |
| 3 | Solubility studies of paraffin waxes in selected petroleum fractions and toluene 显示文摘 | Beg S A Hamad E Tukur N M | 1993 | Fuel Science & Technology International1993，11，2： | 1 |
| 4 | Effect of Plumbago zeylanica extract and certain curing agents on multidrug resistant bacteria of clinical origin显示文摘 | Beg A Z Ahmad I | 2000 | World J Mierobiol Biotechnol2000，16，89： | 1 |
| 5 | Tumor necrosis factor and interleukin-1lead to phosphorylation and loss of I kappa B alpha:a mechanism for NF-kappa B activation显示文摘 | BEG A A FINCO T S NANTERMET P V | 1993 | Mol Cell Biol1993，13，： | 1 |
| 6 | An essential role for NF-kappaB in preventing TNF-alpha-induced cell death 显示文摘 | Beg A A Baltimore D | 1996 | Sci-ence1996，274，： | 1 |
| 7 | Common Fixed Points of Two Maps in Cone Metric Spaces显示文摘 | AZAM A ARSHAD M BEG I | | 0，，： | 1 |
| 8 | An essential role for NF-κB in preventing TNF-α induced cell death 显示文摘 | Beg A Baltimore D | 1996 | Science1996，274，4： | 1 |
| 9 | Embryonic le- thality and liver degeneration in mice lacking the RelA component of NF-kappa B显示文摘 | Beg A A Sha W C Bronson R T | 1995 | Nature1995，376，： | 1 |
| 10 | A study of picosecond laser-solid interactions up to 1019 W·cm-2显示文摘 | Beg F N Bell A R Dangor A E | 1997 | Phys Plasmas1997，4，2： | 1 |
| 11 | Banaeh Contraction Principle on Cone Rectangular Metric Spaces显示文摘 | AZAM A ARSHAD M BEG I | 2009 | Applicable Analy- sis and Discrete Mathematics2009，3，2： | 1 |
| 12 | Follicle selection in cattle and horses:role of intrafollicular factors显示文摘 | BEG M A GINTHER O J | 2006 | Reproduction2006，132，3： | 1 |
| 13 | A study of picosecond laser-solid interactions up to 10^19 W · cm-2显示文摘 | Beg F N Bell A R Dangor A E | 1997 | Phys Plasmas1997，4，： | 1 |
| 14 | Characterization of an immediate-early gene induced in adherent monocytes which IκB-like activity显示文摘 | Haskill S Beg A A Tompkins S A | 1991 | Cell1991，65，7： | 1 |
| 15 | Spatial distribution of Polybrominated diphenyl ethers in coastal marine sediments receiving industrial and municipal effluents in Kuwait 显示文摘 | Gevao B Beg M U A1--Ghadban A N | 2006 | Cbemosphere2006，62，7： | 1 |
| 16 | Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses 显示文摘 | Beg A A | 2002 | Trends in Immunology2002，23，11： | 1 |
| 17 | Study on structural and electrical properties of layered perovskite-type oxide-ion conductor显示文摘 | Beg S A1-Alas A Niyazi A S | 2010 | Mater Chem Phys2010，124，1： | 1 |
| 18 | Non-canonical IKKs, IKKε and TBK1, as novel therapeutic targets in the treatment of non-small cell lung cancer显示文摘 | Jae-Young Kim Amer A Beg Eric B Haura | 2013 | Expert Opinion on Therapeutic Targets2013，，： | 1 |
| 19 | The fuel properties of pyrolysis liquid derived from urban solid wastes in Bangladesh显示文摘 | ISLAM M N BEG M R A | 2004 | Bioresource Technology2004，92，2： | 1 |
| 20 | Pyrolytic oil from fixed bed pyrolysis of municipal solid waste and its characterization显示文摘 | ISLAM M N BEG M R A | 2005 | Renewable Energy2005，30，3： | 1 |
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