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97篇 您的检索式：作者名="Beest"

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	题名	作者	年代	出处	被引量
1	Interleukin-6 secretion is limited by self-signaling in endosomes显示文摘Cells producing cytokines often express the receptor for the same cytokine, which makes them prone to autocrine signaling. How cytokine release and signaling are regulated in the same cell is not understood? In this study, we demonstrate that signaling by exogenous and self-synthesized inflammatory cytokine interleukin-6 (IL-6) within endosomal compartments acts as a cellular brake that limits the synthesis of IL-6. Our data show that IL-6 is internalized by dendritic cells and signals from endosomal compartments containing the IL-6 receptor. Newly synthesized IL-6 also traffics via these endosomal compartments and signals in transit to the plasma membrane. This allows activation of STAT3 which in turn limits toll-like receptor 4 stimulant lipopolysaccharide (LPS) triggered transcription of IL-6. Long-term exposure to LPS removes this brake via inhibition of STAT3 by increased expression of suppressor of cytokine signaling 3 and results in fully fledged IL-6 production. This transient regulation could prevent excessive IL-6 production during early infections.	Danielle R.J.Verboogen Natalia H.Revelo Martin ter Beest Geert van den Bogaart	2019	Journal of Molecular Cell Biology2019，11，2：	2
2	Early hemodynamic resuscitation in septic shock: understanding and modifying oxygen delivery显示文摘	van Beest PA Spronk PE	2014	Crit Care2014，18，1：	1
3	Simple apparatus to measure water vapor resistance of textile显示文摘	BEEST V	1986	Textile Research Journal1986，56，9：	1
4	Polarisation,key to good localisation显示文摘	Van Beest M Robben JH Savelkoul PJ	2006	Biochem Biophys Acta2006，1758，8：	1
5	The incidence of low venous oxygen saturation on ad- mission to the intensive care unit: a multi-center observational study in the Netherlands 显示文摘	Van Beest PA Hofstra J J Schultz M J	2008	Crit Care2008，12，2：	1
6	Developments in the active packaging of foods显示文摘	Vermeiren L Devlieghere F van Beest M	1999	Trends Food Science &- Technology1999，10，3：	1
7	The status of biological control of weeds with fungal pathogens显示文摘	Te Beest D O Yang X B Cisar C R	1992	Ann Rev Phytopathol1992，，30：	1
8	High probability of avian influenza virus(H7N7) transmission form poultry to humans active in disease control on infected farms显示文摘	Bos MEH TE Beest D Van Boven M	2010	JID2010，201，：	1
9	Synergy between tumor suppressor APC and the beta-catenin Tcf-4 target Tcf-1显示文摘	Roose J Huls G Van Beest M	1999	Science1999，285，5435：	1
10	Heat shocks enhance procollagen type I and III expression in fibmblasts in ex vivo human skin显示文摘	Dams SD de Liefde van Beest M Nuijs AM	2011	Skin Res Techno12011，17，2：	1
11	The incidence of low ve- nous oxygen saturation on admission to the intensive care unit: a multi-center observational study in Netherlands显示文摘	Van Beest P Hofstra J Schultz M	2008	Crit Care2008，12，1：	1
12	Stress-induced breathlessness in asthma 显示文摘	Rietveld S Van Beest I Everaerd W	1999	Psychol Med1999，29，6：	1
13	Developments in the active packaging of foods显示文摘	Venneiren L Devlieghere F Van Beest M	1999	Trends in Food Science & Technology1999，，10：	1
14	The status of biological control of weeds with fungal pathogens显示文摘	Te Beest O D Yang X B Cisar C R	1992	Annual Reviews of Phytopathology1992，17，：	1
15	The incidence of low venous oxygen saturation on admission to the intensive care unit:a multi-center observational study in The Netherlands显示文摘	van Beest PA Hofstra JJ Schultz MJ	2008	Crit Care2008，12，：	1
16	Developments in the active packaging of foods显示文摘	Venneiren L Devlieghere F Van Beest M	1999	Trends in Food Science & Technology1999，，10：	1
17	Determinants of persistence with bisphosphonates:a study in women with postmenopausal osteoporsis显示文摘	Penning-van Beest FJA Goettsch WG Erkens JA		0，，：	1
18	Loss of treatment benefit due to low compliance with bisphosphonate therapy显示文摘	Penning-van Beest FJ Erkens JA Olson M	2008	Osteoporosis Int2008，19，4：	1
19	Thiafentanil-dexmedetomi-dine-telazol anesthesia in greater rheas (Rhea americana) 显示文摘	Ter Beest J McClean M Cushing A	2012	J ZooWildl Med2012，43，4：	1
20	pulmonary embolism,myocardial infarction, and ischemicstroke in lung cancer patients: results from a longitudinal study 显示文摘	van Herk-Sukel MP Shantakumar S Penningvan Beest FJ	2013	Lung2013，191，：	1

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