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| 1 | 局灶节段透明变性及硬化在判断IgA肾病预后中的意义显示文摘目的 探讨IgA肾病 (IgAN)进展为慢性肾功能不全 (CRI)的病理学危险因素。方法 对 6 40例经肾活检确诊的IgAN病人进行平均 5 3个月的追踪观察。用病例对照法研究所有病人的病理学资料 ,同时还对其中 2 0 4例活检当时肾功能正常 ,5年后发展为CRI或终末期肾功能衰竭(ESRF) (n =18)以及 5年后肾功能仍保持正常 (n =186 )的病例进行了比较。结果 弥漫性系膜增生型 (DMP)为最常见的病理型 ,占 5 0 %。 / 间质纤维化 ,>40 %硬化肾小球 , / 血管病变 ,局灶节段透明变性及硬化 (FSHS)的均为预测肾功能恶化的危险因素 ,其中FSHS的意义更大 (P <0 0 0 0 1)。结论 FSHS的存在是IgAN病人正常肾功能进展恶化的显著指标。 | 严海东 Packham D Kincaid Smith P Becker G 周希静 | 1999 | 中华肾脏病杂志1999，15，5： | 20 |
| 2 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 3 | Determination of porcine plasma follitropin levels during superovulation treatment in cows显示文摘 | Demoustier M M Beckers J F Zwalmen P V | 1998 | Theriogenology1998，30，2： | 1 |
| 4 | Inhibition of human brain and RBC acetylcholinesterase (ACHE) by heptylphysostigmine (HPTL)显示文摘 | Moriearty P L Becker R E | 1992 | Methods Find Exp Clin Pharmacol1992，14，8： | 1 |
| 5 | Onychomy- cosis in a diabetic patient due to Trichophyton gallinae 显示文摘 | Poblete-Gutierrez P Abuzahra F Becker F | 2006 | Mycoses2006，49，3： | 1 |
| 6 | Measuring patient opinion of pain management显示文摘 | Calvin A Becker H Biering P | 1999 | Pain Symptom Manage1999，18，1： | 1 |
| 7 | Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-anal- ysis 显示文摘 | Chu S G Becker R C Berger P B | 2010 | J Thromb Haemost2010，8，1： | 1 |
| 8 | Virtual reality simulation of surgery with haptic feedback based on the boundary element method显示文摘 | Wang P Becker A A Jones I A | | 0，，7： | 1 |
| 9 | PRRT2-related disorders : further PKD and ICCA cases and review of the literature 显示文摘 | Becker F Schubert J Striano P | 2013 | J Neurol2013，260，5： | 1 |
| 10 | Functional adi- ponectin resistance at the level of the skelet al muscle in mild to moder- ate chronic heart failure 显示文摘 | Van Berendoncks AM Gamier A Beckers P | 2010 | Circ Heart Fail2010，3，2： | 1 |
| 11 | Activation of FOXO1 by Cdkl in cycling cells and postmitotic nettrons显示文摘 | Yuan Z Becker EB Merlo P | 2008 | Science2008，319，： | 1 |
| 12 | Solid-phase crystalli-zation of amorphous silicon on ZnO:Al for thin-film solar cells显示文摘 | Becker C Conrad E Dogan P | 2009 | Solar Energy Mater Solar Cells2009，93，： | 1 |
| 13 | Borate Materials in Nonlinear Optics 显示文摘 | Becker P | 1998 | Advanced Materials1998，10，13： | 1 |
| 14 | Limitation of the butanol-hydrochloric acid-iron assay for bound condensed tannins显示文摘 | Makkar H P S Gamble G Becker K | 1999 | Food Chemistry1999，66，： | 1 |
| 15 | The skin ulceration disease in cultivated juveniles of Holothuria scabra (Holothuroidea,Echonodermata)显示文摘 | Becker P Gillan D Lanterbecq D | 2004 | Aquac2004，242，： | 1 |
| 16 | Leiomyosarcoma of the inferlor vena cava:a case report显示文摘 | Bonamigo T P Becker M Faccini F P | 2003 | Vase Enctovascular Surg2003，37，3： | 1 |
| 17 | Nutritional value and antinutritional components of whole and ethanol ex- tracted Moringa oleifera leaves 显示文摘 | MAKKAR H P S BECKER K | 1996 | Animal Feed Sci- ence Technology1996，63，1： | 1 |
| 18 | Development of a risk tool for deliberate self-extubation in intensive care patients显示文摘 | Moons P Sels K De Becker W | 2004 | Intensive Care Med2004，30，7： | 1 |
| 19 | 查看详情显示文摘 | Becker R. H Guengerich F. P | | 0，，： | 1 |
| 20 | Head Size and Body Mass in Infants With Hydrocephalus显示文摘 | SMITH F J VAN S R BECKER P J | | 0，，01： | 1 |
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