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| 1 | Predictive value of Ki67 and p53 in locally advanced rectal cancer:Correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy显示文摘AIM: To investigate the predictive value of Ki67 and p53 and their correlation with thymidylate synthase (TS) gene expression in a rectal cancer patient cohort treated according to a standardized recommended neoadjuvant treatment regimen.METHODS: Formalin fixed, paraffin embedded pre-therapeutical tumor biopsies (n = 22) and post-therapeutical resection specimens (n = 40) from patients with rectal adenocarcinoma (clinical UICC stage Ⅱ/Ⅲ) receiving standardized neoadjuvant 5-fluorouracil (5-FU) based chemoradiotherapy were studied for Ki67 and p53 expression by immunohistochemistry and correlated with TS mRNA expression by quantitative TaqMan real-time PCR after laser microdissection. The results were compared with histopathological tumor regression according to a standardized semiquantitative score grading system.RESULTS: Responders (patients with high tumor regression) showed a significantly lower Ki67 expression than non-responders in the pre-therapeutical tumor biopsies (81.2% vs 16.7%; P < 0.05) as well as in the post-therapeutical resection specimens (75.8% vs 14.3%; P < 0.01). High TS mRNA expression was significantly correlated with a high Ki67 index and low TS mRNA expression was significantly correlated with a low Ki67 index in the pre-therapeutical tumor biopsies (corr. coef. = 0.46; P < 0.01) as well as in the post-therapeutical resection specimens (corr. coef. = 0.40; P < 0.05). No significant association was found between p53 and TS mRNA expression or tumor regression.CONCLUSION: Ki67 has, like TS, predictive value in rectal cancer patients after neoadjuvant 5-FU based chemoradiotherapy. The close correlation between Ki67 and TS indicates that TS is involved in active cell cycle processes. | Christiane Jakob Torsten Liersch Wolfdietrich Meyer Heinz Becker Gustavo B Baretton Daniela E Aust | 2008 | World Journal of Gastroenterology2008，14，7： | 29 |
| 2 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 3 | Vulnerability of the nigrostriatal system as detected by transcranial ultrasound显示文摘 | Berg D Becker G Zeiler B | 1999 | Neurology1999，53，： | 2 |
| 4 | Combined evaluation of a panel of protein and miRNA serum‐exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity显示文摘 | Bindhu Madhavan Shijing Yue Uwe Galli Sanyukta Rana Wolfgang Gross Miryam Müller Nathalia A. Giese Holger Kalthoff Thomas Becker Markus W Büchler Margot Z?ller | 2015 | Int. J. Cancer2015，，11： | 2 |
| 5 | Heart rate variability in athletes显示文摘 | Aubert A Seps B Beckers F | 2003 | SportsMed2003，33，12： | 1 |
| 6 | Different types of scaffolds for reconstruction of the urinary tract by tissue engineering显示文摘 | Brehmer B Rohrmann D Becker C | 2007 | Urol Int2007，78，1： | 1 |
| 7 | Utstein-style guidelines for uniform reporting of laboratory CPR research显示文摘 | Ahamed H Idris Lance B Becker | 1996 | Resuscitation1996，33，1： | 1 |
| 8 | The construct of resilience:A critical evaluation and guidelines for future work显示文摘 | Luthar S Cicchetti D Becker B | 2000 | Child Dev2000，71，3： | 1 |
| 9 | Oscillatory Motions Sunspots 显示文摘 | Beckers J M Schuhz R B | 1972 | Solar Physics1972，27，1： | 1 |
| 10 | Cyclocryotherapy in neovascular glaucoma显示文摘 | Krupin T Mitchell KB Becker B | 1978 | Am J Ophthalmol1978，86，： | 1 |
| 11 | CT of coronary artery disease显示文摘 | SCHOEPF U J BECKER C R OHNESORGE B M | 2004 | Radiology2004，23，1： | 1 |
| 12 | Nursing interventions and patient outcomes: A meta - analysis of studies 显示文摘 | Heater B Becker A Olsen R | 1988 | Nurse Res1988，37，： | 1 |
| 13 | Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-anal- ysis 显示文摘 | Chu S G Becker R C Berger P B | 2010 | J Thromb Haemost2010，8，1： | 1 |
| 14 | Volumetric analysis of simulated alveolar cleft defects and bone grafts using cone beam computed tomography 显示文摘 | Amirlak B Tang C J Becker D | 2013 | Plast Reeonstr Surg2013，131，4： | 1 |
| 15 | lnterproximal biofilm removal by intervallie use of a sonic toothbrush compared to an oral irrigation system显示文摘 | Tawakoli PN Sauer B Becker K | 2015 | BMC Oral Health2015，15，： | 1 |
| 16 | Public R&D policies and private R&D investment: A survey of the empirical evidence显示文摘 | Becker B | 2015 | Journal of Economic Surveys2015，29，5： | 1 |
| 17 | Preconditioning-induced neuroprotection is mediated by reactive oxygen species and activation of the transcription factor nuclear factor-kappaB 显示文摘 | Ravati A Ahlemeyer B Becker A | 2001 | J Neurochem2001，78，4： | 1 |
| 18 | Constitutive modeling of viscoelastic materials with damage: Computational aspects 显示文摘 | Conga M E Becker E B Ozupek S | 2001 | Computer Methods in Applied Mechanics and Engineering2001，190，1517： | 1 |
| 19 | Strategic human resource management : where do we go from here? 显示文摘 | Becker B E Huselid M A | 2006 | Journal of Management2006，，32： | 1 |
| 20 | Cardiac imaging with rapid retrospective ECG synchronized multilevel spiral CT显示文摘 | Ohnesorge B Flohr T Becker C | 2000 | Radiology2000，40，4： | 1 |
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