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| 1 | Intragenic antagonistic roles of protein and circRNA in tumorigenesis显示文摘circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic RNA independently and antithetically to its linear transcript counterpart, which acts as a tumor suppressor by encoding the Pokemon transcription factor. We find that circPOK regulates pro-proliferative and pro-angiogenic factors by co-activation of the ILF2/3 complex. Importantly, the expression of Pokemon protein and circRNA is aberrantly uncoupled in cancer through differential post-transcriptional regulation. Thus, we identify a novel type of genetic unit, the iRegulon, that yields biochemically distinct RNA products, circular and linear, with diverse and antithetical functions. Our findings further expand the cellular repertoire towards the control of normal biological outputs, while aberrant expression of such components may underlie disease pathogenesis including cancer. | Jlenia Guarnerio Yang Zhang Giulia Cheloni Riccardo Panella Jesse Mae Katon Mark Simpson Akinobu Matsumoto Antonella Papa Cristian Loretelli Andreas Petri Sakari Kauppinen Cassandra Garbutt Gunnlaugur Petur Nielsen Vikram Deshpande Mireia Castillo-Martin Carlos Cordon-Cardo Spentzos Dimitrios John G. Clohessy Mona Batish Pier Paolo Pandolfi | 2019 | Cell Research2019，29，8： | 15 |
| 2 | Allelopathic interactions and allel- ochemicals: new possibilities for sustainable weed manage-ment 显示文摘 | Singh H P Batish D R Kohli R K | 2003 | Critical Rev Plant Sci2003，22，： | 1 |
| 3 | Chemical composition of essential oil from of Chenopodium ambrosioides from Chandigarh,India显示文摘 | Singh H P Batish D R Kohi R K | 2008 | Chemistry of natural compounds2008，44，3： | 1 |
| 4 | Allelopathy and Its Implications in Agroecosystems显示文摘 | KOHLI R K BATISH D SINGH H P | 1998 | Crop Prot1998，，1： | 1 |
| 5 | Phytotoxic interference of Ageratum conyzoides with wheat (Triticum aestivum) 显示文摘 | Singh HP Batish DR Kaur S | 2003 | Journal of Agronomy & Crop Science2003，189，5： | 1 |
| 6 | Antifungal activity of the volatile oil of Eucalyptus citriodora 显示文摘 | Ramezani H Singh HP Batish DR | 2002 | Fitoterapia2002，73，3： | 1 |
| 7 | Screening lactic starter cultures for antifungal activity显示文摘 | Batish V K Grover S Lal R | 1989 | Cultured Dairy Products Journal1989，24，： | 1 |
| 8 | Factors affecting amine production by a selected strain of Lactobacillus Bulgaricus显示文摘 | Chander H Batish V H | 1989 | Journal of Food Science1989，54，： | 1 |
| 9 | Anti-MuSK myasthenia gravis presenting with purely ocular findings显示文摘 | Caress JB Hunt CH Batish SD | 2005 | Arch Neurol2005，62，6： | 1 |
| 10 | Allelopathic interactions and allelochemicals:new possibilities for sustainable weed management显示文摘 | Singh H P Batish D R Kohli R K | 2003 | Critical reviews in plant sciences2003，22，： | 1 |
| 11 | Artemisia scoparia essen- tial oil inhibited root growth involves reactive oxygen species (ROS) -mediated disruption of oxidative metabolism: in vivo ROS deteetion and alterations in antioxidant enzymes 显示文摘 | Kaur S Singh H P Batish D R | 2012 | Biochem Syst Ecol2012，44，： | 1 |
| 12 | Assessment of in vitro antioxidant activity of essential oil of Eucalyptus citriodora (lemon-scented Eucalypt; Myrtaceae) and its major constituents显示文摘 | Harminder Pal Singh Shalinder Kaur Kirti Negi Savita Kumari Varinder Saini Daizy R. Batish Ravinder Kumar Kohli | 2012 | LWT - Food Science and Technology2012，，2： | 1 |
| 13 | Application of multiplex PCR assay based on uidR and fliCH7 genes for detection of Escherichia coli O157:H7 in milk显示文摘 | Kumar A Grover S Kumar Batish V | 2013 | The Journal of general and applied microbiology2013，59，1： | 1 |
| 14 | Phytotoxic ef- fects of β-pinene on early growth and associated bio- chemical changes in rice显示文摘 | Chowhan N Singh H P Batish D R | 2011 | Acta Physiol Plant2011，33，： | 1 |
| 15 | Understanding the intention to permanently follow a high floate diet among a sample of low-income pregnant women according to the Health Belief Model显示文摘 | Kloeblen AS Batish SS | | 0，，3： | 1 |
| 16 | Pytotoxic effect of Parthenium residues on the selected soil properties and growth of chickpea and radish显示文摘 | Batish D R Singh H P Pandher J K | 2002 | Weed Biology and Management2002，2，： | 1 |
| 17 | alpha-pinene inhibits growth and induces oxidative stress in roots显示文摘 | Singh H P Batish D R Kaur S Arora K Kohli R K | 2006 | Ann Bot2006，98，6： | 1 |
| 18 | Antifungal attributes of lacticacid bacteria-a review显示文摘 | Batish V K Roy U Lal R | 1997 | Critical Reviews in Biotechnology1997，17，： | 1 |
| 19 | Autotoxicity: concept, organisms, and ecological significance显示文摘 | Singh H P Batish D R Kohli R K | 1999 | Critical Reviews in Plant Sciences1999，18，： | 1 |
| 20 | Autotoxicity:concept,organisms and ecological significance显示文摘 | Singh H P Batish D R Kohli R K | 1999 | Critical Reviews in Plant Sciences1999，18，： | 1 |
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