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| 1 | An Estimation of Distribution Algorithm Forminimizing the Total Flowtime in Permutation Flowshop Scheduling Problems显示文摘 | Bassem J Mansour E Patrick S | 2009 | Computers & Operations Research2009，36，： | 1 |
| 2 | The Geriatric Assessment显示文摘 | Bassem E Higgins K | 2011 | American Family Physician2011，83，： | 1 |
| 3 | Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial显示文摘 | Jeffrey E Rubnitz Hiroto Inaba Gary Dahl Raul C Ribeiro W Paul Bowman Jeffrey Taub Stanley Pounds Bassem I Razzouk Norman J Lacayo Xueyuan Cao Soheil Meshinchi Barbara Degar Gladstone Airewele Susana C Raimondi Mihaela Onciu Elaine Coustan-Smith James R D | 2010 | Lancet Oncology2010，，6： | 1 |
| 4 | Overpression of the nuclear receptor coactivator AIB1 (SRC-3) during progression of pancreatic adenocarcinoma显示文摘 | RALF T H BASSEM R H SUNG E K | 2004 | Clinical Cancer Reserch2004，10，： | 1 |
| 5 | Excellent laundry detergent compatibility and high dehairing ability of the Baeillus pumilus CBS alkaline proteinase (SAPB) 显示文摘 | Bassem J Semia E C Mamdouh B A | 2009 | Biotechnology and Bioproeess Engineering2009，14，4： | 1 |
| 6 | Assessment of antimycotoxigenic and antioxidant activity of star anise (Illicium verum) in vitro显示文摘 | Soher E Aly Bassem A Sabry Mohamed S Shaheen | 2014 | Journal of the Saudi Society of Agricultural Sciences2014，9，1： | 1 |
| 7 | Rotoresection versus transurethral resection of the prostate: short-term evaluation of a prospective randomized study显示文摘 | Shady A Soliman Bassem S Wadie El-Husseiny E Ibrahim | 2007 | J Urol2007，177，： | 1 |
| 8 | Biochemical and mo- lecular characterization of adetergent-stable serine alkaline protease from Bacillus pumilus CBS with high catalytic effi- ciency显示文摘 | Bassem J Semia E C Moez R | 2008 | Biochimie2008，90，： | 1 |
| 9 | The geriatric assessment 显示文摘 | Bassem E Kim EH | 2011 | Am Fam Physician2011，83，： | 1 |
| 10 | Impact of high dose vitamin C on platelet function显示文摘AIM To examine the effect of high doses of vitamin C(VitC) on ex vivo human platelets(PLTs).METHODS Platelet concentrates collected for therapeutic or prophylactic transfusions were exposed to:(1) normal saline(control);(2) 0.3 mmol/L VitC(Lo VitC); or(3) 3 mmol/L VitC(Hi VitC, final concentrations) and stored appropriately. The Vit C additive was preservative-free buffered ascorbic acid in water, pH 5.5 to 7.0, adjusted with sodium bicarbonate and sodium hydroxide. The doses of Vit C used here correspond to plasma Vit C levels reported in recently completed clinical trials. Prior to supplementation, a baseline sample was collected for analysis. PLTs were sampled again on days 2, 5 and 8 and assayed for changes in PLT function by: Thromboelastography(TEG), for changes in viscoelastic properties; aggregometry, for PLT aggregation and adenosine triphosphate(ATP) secretion in response to collagen or adenosine diphosphate(ADP); and flow cytometry, for changes in expression of CD-31, CD41 a, CD62 p and CD63. In addition, PLT intracellular Vit C content was measured using a fluorimetric assay for ascorbic acid and PLT poor plasma was used for plasma coagulation tests [prothrombin time(PT), partial thrombplastin time(PTT), functional fibrinogen] and Lipidomics analysis(UPLC ESI-MS/MS).RESULTS VitC supplementation significantly increased PLTs intracellular ascorbic acid levels from 1.2 mmol/L at baseline to 3.2 mmol/L(Lo VitC) and 15.7 mmol/L(Hi VitC, P < 0.05). VitC supplementation did not significantly change PT and PTT values, or functional fibrinogen levels over the 8 d exposure period(P > 0.05). PLT function assayed by TEG, aggregometry and flow cytometry was not significantly altered by Lo or Hi VitC for up to 5 d. However, PLTs exposed to 3 mmol/L VitC for 8 d demonstrated significantly increased R and K times by TEG and a decrease in the α-angle(P < 0.05). There was also a fall of 20 mm in maximum amplitude associated with the Hi VitC compared to both baseline and day 8 saline controls. Platelet aggregation studies, showed uniform declines in collagen and ADP-induced platelet aggregations over the 8-d study period in all three groups(P > 0.05). Collagen and ADP-induced ATP secretion was also not different between the three groups(P > 0.05). Finally, VitC at the higher dose(3 mmol/L) also induced the release of several eicosanoids including thromboxane B2 and prostaglandin E2, as well as products of arachidonic acid metabolism via the lipoxygenases pathway such as 11-/12-/15-hydroxyicosatetraenoic acid(P < 0.05).CONCLUSION Alterations in PLT function by exposure to 3 mmol/L VitC for 8 d suggest that caution should be exerted with prolonged use of intravenous high dose VitC. | Bassem M Mohammed Kimberly W Sanford Bernard J Fisher Erika J Martin Daniel Contaifer Jr Urszula Osinska Warncke Dayanjan S Wijesinghe Charles E Chalfant Donald F Brophy Alpha A Fowler Ⅲ Ramesh Natarajan | 2017 | World Journal of Critical Care Medicine2017，6，1： | 0 |
| 11 | 在一个直肠的肿瘤和它的肺复发之间的基因错误的惹人注目的类似显示文摘 We are reporting the longest disease-free interval ever published for colorectal cancer, using gene profiling to confirm the linkage of the primary and metastasis. This rare case reports on a patient with late recurrence of colorectal cancer in the lung 19 years after its initial diagnosis. We used high-resolution array CGH(aCGH) to analyze the genetic aberrations of both the primary rectal and the recurrent metastatic lung lesions. Interestingly, we found striking similarities between the two lesions, despite the 19 years disease-free interval.In addition, most of the genes that were previously reported to be associated with a high recurrence score showed copy number gains by aCGH in one or both lesions. Our findings suggest that aCGH may be a helpful tool in analyzing the origin of metastatic lesions and reflect the need for a better understanding of the characteristics of the rectal tumors with a late recurrence potential. | Osama E Rahma Mauricio Burotto Luisa Matos Do Canto Alexandre A Germanos Bassem R Haddad John L Marshall | 2013 | World Journal of Gastrointestinal Oncology2013，5，11： | 0 |
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