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| 1 | Soluble ST2:A new and promising activity marker in ulcerative colitis显示文摘AIM:To correlate circulating soluble ST2(sST2) levels with the severity of ulcerative colitis(UC) and serum levels of pro-inflammatory cytokines,and to demonstrate the predictive power of sST2 levels for differentiation between active and inactive UC.METHODS:We recruited 153 patients:82 with UC,26 with Crohn's disease(CD) and 43 disease controls [non-inflammatory bowel disease(IBD)].Subjects were excluded if they had diagnosis of asthma,autoimmune diseases or hypertension.The serum levels of sST2 and pro-inflammatory cytokines [pg/mL;median(25th-75th)] as well as clinical features,endoscopic and histological features,were subjected to analyses.The sST2 performance for discrimination between active and inactive UC,non-IBD and healthy controls(HC) was determined with regard to sensitivity and specificity,and Spearman's rank correlation coefficient(r).To validate the method,the area under the curve(AUC) of receiver-operator characteristic(ROC) was determined(AUC,95% CI) and the total ST2 content of the colonic mucosa in UC patients was correlated with circulating levels of sST2.RESULTS:The serum sST2 value was significantly higher in patients with active [235.80(90.65-367.90) pg/mL] rather than inactive UC [33.19(20.04-65.32) pg/mL],based on clinical,endoscopic and histopathological characteristics,as well as compared with non-IBD and HC(P < 0.001).The median level of sST2 in CD patients was 54.17(35.02-122.0) pg/mL,significantly higher than that of the HC group only(P < 0.01).The cutoff was set at 74.87 pg/mL to compare active with inactive UC in a multicenter cohort of patients.Values of sensitivity,specificity,and ability to correctly classify UC,according to activity,were 83.33%,83.33% and 83.33%,respectively.The AUC of the ROC curve to assess the ability of this molecule to discriminate between active vs inactive UC was 0.92(0.86-0.97,P < 0.0001).The serum levels of sST2 in patients with UC significantly correlated with endoscopic and histo-pathological scores(r = 0.76 and r = 0.67,P < 0.0001,respectively),and with the pro-inflammatory cytokine,tumor necrosis factor-α(r = 0.69 and r = 0.61,respectively,P < 0.0001).Interestingly,we found a direct correlation between total intestinal ST2 content and serum levels of sST2,adjusted to endoscopic activity score in patients with mild(r = 0.44,P = 0.004),moderate(r = 0.59,P = 0.002) and severe disease(r = 0.82,P = 0.002).Only patients with inactive UC showed no significant correlation(r = 0.45,P = 0.267).CONCLUSION:sST2 levels correlated with disease severity and inflammatory cytokines,are able to differentiate active from inactive UC and might have a role as a biomarker. | David Díaz-Jiménez Lucía E Núez Caroll J Beltrán Enzo Candia Cristóbal Suazo Manuel varez-Lobos María-Julieta González Marcela A Hermoso Rodrigo Quera | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 2 | Improving Quality of Care and Patient Safety through Morbidity and Mortality Conferences显示文摘 | Bal G Sellier E Tchouda SD | 2014 | J Healthc Qual2014，36，1： | 1 |
| 3 | Characterization of the solid third phase that precipitate from the organic solutions of Aliquat 336 after extraction of molybdenum (VI) and vanadium(V) 显示文摘 | Bal Y Bal K E Cote G | 2004 | Hydrometallurgy2004，75，11： | 1 |
| 4 | Fuzzy logic based DSP controlled servo position control for ultrasonic motor 显示文摘 | BAL G G BEKIROGL U E DEMIRBAS S | 2004 | Energy Conversion and management2004，，： | 1 |
| 5 | Decreased mito-chondrial nitric oxide synthase activity and hydrogen peroxide relate persistent tumoral proliferation to embryonic behavior 显示文摘 | Galli S Labato MI Bal de Kier Joffe E | 2003 | Cancer Res2003，63，19： | 1 |
| 6 | Long-term prognostic role of coronary flow velocity reserve in patients with aortic valve stenosisinsights from the SZEGED Study显示文摘 | Nemes A Balázs E Csanády M | 2009 | Clin Physiol Funct Imaging2009，29，6： | 1 |
| 7 | β-type natriuretic peptide (BNP) and N-terminal-proBNP for heart failure diagnosis in shock or acute respiratory distress 显示文摘 | BAL THIERRY S BROCAS E | 2006 | Acta Anaesthesiol Scand2006，50，3： | 1 |
| 8 | A highly effective load adaptive servo drive system for speed control of travelling-wave ultrasonic motor显示文摘 | Bal G Bekiroglu E | 2005 | IEEE Transactions on Power Electronies2005，20，5： | 1 |
| 9 | Psychological contract breach and job attitudes:A meta-analysis of age as a moderator 显示文摘 | Bal P M De Lange A H Jansen P G W Der Velde M E G V | 2008 | Journal of Vocational Behavior2008，72，1： | 1 |
| 10 | Vulvar syringoma aggravated by pregnancy 显示文摘 | Bal N Asian E Kavaselcuk F | 2003 | Pathol Oncol Res2003，9，3： | 1 |
| 11 | The effects of gender difference on monocrotaline-induced pulmonary hypertension in rats显示文摘 | Bal E Ilgin S Atli O Ergun B Sirmagul B | 2013 | Human and Experimental Toxicology2013，，7： | 1 |
| 12 | Combined treatment with verapamil,a calcium channel blocker,and B428,a synthetic uPA inhibitor,impairs the metastatic ability of a murine mammary carcinoma显示文摘 | Todaro LB Ladeda V Bal de Kier Joffe E | 2003 | Oncol Rep2003，10，3： | 1 |
| 13 | 砷暴露工人的主动脉弹性参数评价显示文摘砷对人体健康影响的主要并发症就是高血压。砷相关性高血压,及砷对动脉系统的不良反应如氧化应激、血管收缩/舒张失衡可能导致主动脉的弹性受损。该研究旨在评估砷对主动脉弹性参数,包括主动脉应变力和扩张性的影响。方法:纳入职业性砷暴露工人112例和健康对照组人群60名作为研究对象。 | 刘莉 叶鹏 Karakulak UN Yilmaz OH Tutkun E Aladag E Evranos B Bal C Gunduzoz M Ayturk M Ozturk MT | 2016 | 中华高血压杂志2016，24，4： | 1 |
| 14 | B - tyoe natriuretic peptide (BNP) and N - terminal - proBNP for heart failure diagnosis in shock or acute respiratory distress显示文摘 | Bal L Thierry S Brocas E | 2006 | Acta Anaesthesiol Scand2006，50，： | 1 |
| 15 | Wheat scab: perspective and 7 control显示文摘 | Bal G H Shaner G E | 1994 | Plant Dis1994，78，： | 1 |
| 16 | Immediate versus deferred coronary angioplasty in non-ST-elevation acute coronary syndromes 显示文摘 | Riezebos RK Ronner E Ter Bals E | 2009 | Heart2009，95，17： | 1 |
| 17 | The influence of the pore size, the foaming temperature and the viscosity of the continuous phase on the properties of foams produced by membrane foaming 显示文摘 | BALS A KULOZIK E | 2003 | J Membrane Sci2003，220，1： | 1 |
| 18 | Factors influencing the level of circulating procoagulant microparticles in acute pulmonary embolism显示文摘 | Bal L Ederhy S Di Angelantonio E | 2010 | Arch Cardiovasc Dis2010，103，67： | 1 |
| 19 | Pseudo-embryo genic structures in anther and isolated microspore cultures in vitro=a cautionary guide显示文摘 | Bal U Shariatpanahi M E Castro A J | 2012 | Czech Journal of Genetics and Plant Breeding2012，48，2： | 1 |
| 20 | Comparison of dorsal and volar percutaneous screw fixation methods in acute Type B scaphoid fractures显示文摘 | Gürbüz Y Kayalar M Bal E | 2012 | Acta Orthop Traumatol Turc2012，46，5： | 1 |
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