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| 1 | Effect of Lycium barbarum Polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma显示文摘Lycium barbarum, a traditional Chinese anti-aging herb, has been shown to protect retinal ganglion cells (RGCs) in a rat chronic ocular hypertension (COH) model. Here, we investigated the expression of endothelin-1 (ET-1), a strong vasoconstrictor, and its receptors, ETA and ETB, in the COH model and assessed the effects of Lycium barbarum on the ET-1 axis. Elevated intraocular pressure (IOP) was induced in the right eye of SD rats using argon laser photocoagulation. (1) The expression of ET-1, ETA and ETB in normal and COH retinas was studied. (2) Some COH rats were fed daily with Lycium barbarum Polysaccharides (LBP) using 1 mg/kg or phosphate-buffered saline (PBS) for 3 weeks (started 1 week before photocoagulation). The effects of LBP on the expression of ET-1 and its receptors, ETA and ETB, in COH retina were evaluated. A semi-quantitative analysis of staining intensity was used to evaluate the expression levels of ET-1, ETA and ETB in retinal vasculature. We found that (1) Under COH condition, the immunoreactivity of ET-1 was increased in retina associated with an increase of ETB receptor immunoreactivity and a decrease of ETA receptor immunoreactivity. (2) After feeding COH rats with LBP, the expression of ET-1 was decreased with an increase of ETA expression and a decrease of ETB expression in the retina, especially in RGCs. (3) By comparing the staining intensity in the vasculature of COH retina in LBP-fed group with PBS-fed group, there was a decrease in the expression of ET-1 and ETA and an increase in ETB. In summary, ET-1 expression was up-regulated in the retina in COH model. LBP could decrease the expression of ET-1 and modulate the expression of its receptors, ETA and ETB, under the condition of COH. The neuroprotective effect of LBP on RGCs might be related to its ability to regulate the ET-1-mediated biological effects on RGCs and retinal vasculature. | Xue-Song Mi Kin Chiu Geoffrey Van Justin Wai Chung Leung Amy Cheuk Yin Lo SookjaKim Chung Raymond Chuen-Chung Chang Kwok-Fai So | 2012 | Neural Regeneration Research2012，7，9： | 14 |
| 2 | Lycium barbarum polysaccharides related RAGE and Aβ levels in the retina of mice with acute ocular hypertension and promote maintenance of blood retinal barrier显示文摘Our previous study verified the protective effects of Lycium barbarum polysaccharides(LBP)on retinal neurons and blood vessels in acute ocular hypertension(AOH)mice.To investigate the effect of LBP on the reactivity of retinal glial cells,an AOH mouse model was established in one eye by maintaining ocular hypertension of 90 mm Hg for 60 minutes.Either LBP solution(1 mg/kg)or phosphate-buffered saline was administrated to the mice by gavage daily,starting 7 days before the AOH insult and continuing until the mice were sacrificed for specimen collection on day 4 post-insult.After AOH insult,increased numbers of astrocytes and microglia were observed,together with decreased expression of the following glial cell biomarkers in the retinal ganglion cells of AOH mice:glial fibrillary acidic protein,glutamine synthetase,aquaporin-4,S-100 proteins,ionized calcium-binding adaptor molecule 1,amyloid precursor protein and receptor of advanced glycosylation end-products.After intervention with LBP,the above changes were significantly reduced.Remarkably,morphological remodeling of blood vessel-associated retinal astrocytes,marked by glial fibrillary acidic protein,was also observed.These results,taken together,suggest that LBP regulated the production of amyloid-βand expression of receptor of advanced glycosylation end-products,as well as mediating the activity of retinal glial cells,which may lead to the promotion of better maintenance of the blood-retinal barrier and improved neuronal survival in AOH insult.This study was approved by the Committee for the Use of Live Animals in Teaching and Research(approval No.CULTRA-#1664-08). | Xue-Song Mi Qian Feng Amy Cheuk Yin Lo Raymond Chuen-Chung Chang Sookja Kim Chung Kwok-Fai So | 2020 | Neural Regeneration Research2020，15，12： | 8 |
| 3 | Overview of the Shenzhen Emergency Medical Service Call Pattern显示文摘BACKGROUND:In Shenzhen,the Emergency Medical Service(EMS) system has been in service since 1997.This study aims to examine the operation of Shenzhen 120 EMS center and to identify the reasons of calling EMS.METHODS:In this retrospective quantitative descriptive study,the data from the Shenzhen 120 EMS registry in 2011 were analyzed.RESULTS:Shenzhen 120 EMS center is a communication command center.When the number of 120 are dialed,it is forwarded to the closest appropriate hospital for ambulance dispatch.In2011,the Shenzhen 120 EMS center received 153 160 ambulance calls,with an average of 420 calls per day.Calling emergency services was mainly due to traffic accidents.Trauma and other acute diseases constituted a majority of ambulance transports.The adult patients aged 15-60 years are the principal users of EMS.There are no recognized 'paramedic' doctors and nurses.The pre-hospital emergency service is under the operation of emergency departments of hospitals.Shenzhen at present does not have specialized pre-hospital training for doctors and nurses in posttrauma management.Moreover,specialized pre-hospital training,financial support,and public health education on proper use of EMS should be emphasized.CONCLUSION:The Shenzhen 120 EMS center has its own epidemiology characteristics.Traumatic injury and traffic accident are the main reasons for calling ambulance service.In-depth study emphasizing the distribution and characteristics of trauma patients is crucial to the future development of EMS. | Shuk Man Lo Yi Min Yu Lap Yip Larry Lee Mi Ling Eliza Wong Sek Ying Chair Edward J Kalinowski Tak Shing Jimmy Chan | 2012 | World Journal of Emergency Medicine2012，3，4： | 4 |
| 4 | Secondary metabolites of petri-dish cultured Antrodia camphorata and their hepatoprotective activities against alcohol-induced liver injury in mice显示文摘Antrodia camphorata, a well-known and highly valued edible medicinal mushroom with intriguing activities like liver protection, has been traditionally used for the treatment of alcoholic liver disease. A. camphorata shows highly medicinal and commercial values with the demand far exceeds the available supply. Thus, the petri-dish cultured A. camphorata(PDCA) is expected to develope as a substitute. In this paper, nineteen triterpenes were isolated from PDCA, and thirteen of them were the unique anthroic acids in A. camphorata, including the main content antcin K, which suggested that PDCA produced a large array of the same anthroic acids as the wild one. Furthermore, no obvious acute toxicity was found suggesting the edible safety of PDCA. In mice alcohol-induced liver injury model, triglyceride(TG), aspartate aminotransferase(AST), alanine aminotransferase(ALT), and malondialdehyde(MDA) had been reduced by the PDCA powder as well as the main content antcin K, which indicated that the PDCA could protect alcoholic liver injury in mice model and antcin K could be the effective component responsible for the hepatoprotective activities of PDCA against alcoholic liver diseases. | WU Yu TIAN Wen-Jing GAO Shuo LIAO Zu-Jian WANG Guang-Hui LO Jir-Mehng LIN Pei-Hsin ZENG De-Quan QIU Da-Ren LIU Xiang-Zhong ZHOU Mi LIN Ting CHEN Hai-Feng | 2019 | Chinese Journal of Natural Medicines2019，17，1： | 4 |
| 5 | Fucoidan-Based Theranostic Nanogel for Enhancing Imaging and Photodynamic Therapy of Cancer显示文摘In this study, a fucoidan-based theranostic nanogel(CFN-gel) consisting of a fucoidan backbone, redox-responsive cleavable linker and photosensitizer is developed to achieve acti-vatable near-infrared fluorescence imaging of tumor sites and an enhanced photodynamic therapy(PDT) to induce the com-plete death of cancer cells. A CFN-gel has nanomolar a nity for P-selectin, which is overexpressed on the surface of tumor neovascular endothelial cells as well as many other cancer cells. Therefore, a CFN-gel can enhance tumor accumulation through P-selectin targeting and the enhanced permeation and retention e ect. Moreover, a CFN-gel is non-fluorescent and non-phototoxic upon its systemic administration due to the aggregation-induced self-quenching in its fluorescence and singlet oxygen generation. After internalization into cancer cells and tumor neovascular endothelial cells, its photoactivity is recovered in response to the intracellular redox potential, thereby enabling selective near-infrared fluorescence imaging and an enhanced PDT of tumors. Since a CFN-gel also shows nanomolar a nity for the vascular endothelial growth factor, it also provides a significant anti-tumor e ect in the absence of light treatment in vivo. Our study indicates that a fucoidan-based theranostic nanogel is a new theranostic material for imaging and treating cancer with high e cacy and specificity. | Mi Hyeon Cho Yan Li Pui‑Chi Lo Hyeri Lee Yongdoo Choi | 2020 | Nano-Micro Letters2020，12，4： | 2 |
| 6 | Genomic analy-sis of clinical samples with serologic ABO blood groupingdiscrepancies : identification of 15 novel A and B subgroupalleles显示文摘 | Martin LO Nidal MI Bahram HM | 1998 | Blood1998，5，4： | 1 |
| 7 | Protection of retinal ganglion ceils and retinal vaseulature by Lycium barbarum polysaeeharides in a mouse model of acute ocular hypertension 显示文摘 | Mi X S Feng Q Lo A C | 2012 | PloS One2012，7，45： | 1 |
| 8 | Progressive retinal degeneration in transgenic mice with overexpression of endothelin-1 in vascular endothelial cells显示文摘 | Mi XS Zhang X Feng Q Lo AC Chung SK So KF | 2012 | Invest Ophthalmol Vis Sci2012，53，8： | 1 |
| 9 | CGRP-RCP: a novel pro- tein required for signal transduetion at CGRP and adrenomedullin re- ceptors显示文摘 | Evans BN Rosenblatt MI Mnayer LO | 2000 | J Bid Chem2000，275，31： | 1 |
| 10 | Informed consent in human oocyte embryo, and embryonic stem cell research 显示文摘 | Lo B Chou V Cedars MI | 2004 | Fertil Steril2004，82，3： | 1 |
| 11 | CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors 显示文摘 | Evans BN Rosenblatt MI Mnayer LO | 2000 | J Biol Chem2000，275，31： | 1 |
| 12 | Post-liver transplant obesity and diabetes显示文摘 | Correia MI Rego LO Lima AS | 2003 | Curr Opin Clin Nutr Metab Care2003，6，4： | 1 |
| 13 | CGRPRCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors 显示文摘 | Evans BN Rosenblatt MI Mnayer LO | 2000 | J Biol Chem2000，275，31： | 1 |
| 14 | Protection of retinal ganglion cells and retinal vasculature by Lyciumbarbarum polysaccharides in a mouse model of acute ocular hypertension 显示文摘 | Mi XS Feng Q Lo AC | 2012 | PLoS One2012，7，45： | 1 |
| 15 | Amadori S:Clinical Significance of ZAP-70 protein expression in B-cdll chronin lymphocytic leukemia显示文摘 | Del Principe MI Del poeta G Buccisano F Maurillo L Venditti A Zucchetto A Marini R Niscola P Irno Consalvo MA Mazzone C Ottaviani L Panetta P Bruno A Bomben R Suppo G Degan M Gattei V de Fabritiis P Cantonetti M Lo Coco F Del Principe D | 2006 | Blood2006，，： | 1 |
| 16 | Modeling and simulation of the dynamic performance of a natural-gas turbine flow meter显示文摘 | LO'PEZ-GONZA'LEZ L M SALA J M GONZA'LEZ-BUSTAMANTE J A MI'GUEZ J L | | 0，，： | 1 |
| 17 | Radiotheray fort kapo- si' s Sarcoma显示文摘 | LO TCM Salzmen FA Smedal MI | 1980 | Cancer1980，45，4： | 1 |
| 18 | CGRPRCP, a novel protein required for signal transductionat calcitonin gene-related peptide and adrenomedullin receptors 显示文摘 | Evans BN Rosenblatt MI Mnayer LO | 2000 | J Biol Chem2000，275，31： | 1 |
| 19 | 显示文摘 | Evans BN Rosenblatt MI Mnayer LO | 2000 | J Biol Chem2000，275，31： | 1 |
| 20 | Protection of retinal gangli- on cells and retinal vasculature by lycium barbarum polysac- charides in a mouse model of acute ocular hypertension 显示文摘 | Mi XS Feng Q Lo AC | 2012 | PLoS One2012，7，45： | 1 |
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