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| 1 | Soluble ST2:A new and promising activity marker in ulcerative colitis显示文摘AIM:To correlate circulating soluble ST2(sST2) levels with the severity of ulcerative colitis(UC) and serum levels of pro-inflammatory cytokines,and to demonstrate the predictive power of sST2 levels for differentiation between active and inactive UC.METHODS:We recruited 153 patients:82 with UC,26 with Crohn's disease(CD) and 43 disease controls [non-inflammatory bowel disease(IBD)].Subjects were excluded if they had diagnosis of asthma,autoimmune diseases or hypertension.The serum levels of sST2 and pro-inflammatory cytokines [pg/mL;median(25th-75th)] as well as clinical features,endoscopic and histological features,were subjected to analyses.The sST2 performance for discrimination between active and inactive UC,non-IBD and healthy controls(HC) was determined with regard to sensitivity and specificity,and Spearman's rank correlation coefficient(r).To validate the method,the area under the curve(AUC) of receiver-operator characteristic(ROC) was determined(AUC,95% CI) and the total ST2 content of the colonic mucosa in UC patients was correlated with circulating levels of sST2.RESULTS:The serum sST2 value was significantly higher in patients with active [235.80(90.65-367.90) pg/mL] rather than inactive UC [33.19(20.04-65.32) pg/mL],based on clinical,endoscopic and histopathological characteristics,as well as compared with non-IBD and HC(P < 0.001).The median level of sST2 in CD patients was 54.17(35.02-122.0) pg/mL,significantly higher than that of the HC group only(P < 0.01).The cutoff was set at 74.87 pg/mL to compare active with inactive UC in a multicenter cohort of patients.Values of sensitivity,specificity,and ability to correctly classify UC,according to activity,were 83.33%,83.33% and 83.33%,respectively.The AUC of the ROC curve to assess the ability of this molecule to discriminate between active vs inactive UC was 0.92(0.86-0.97,P < 0.0001).The serum levels of sST2 in patients with UC significantly correlated with endoscopic and histo-pathological scores(r = 0.76 and r = 0.67,P < 0.0001,respectively),and with the pro-inflammatory cytokine,tumor necrosis factor-α(r = 0.69 and r = 0.61,respectively,P < 0.0001).Interestingly,we found a direct correlation between total intestinal ST2 content and serum levels of sST2,adjusted to endoscopic activity score in patients with mild(r = 0.44,P = 0.004),moderate(r = 0.59,P = 0.002) and severe disease(r = 0.82,P = 0.002).Only patients with inactive UC showed no significant correlation(r = 0.45,P = 0.267).CONCLUSION:sST2 levels correlated with disease severity and inflammatory cytokines,are able to differentiate active from inactive UC and might have a role as a biomarker. | David Díaz-Jiménez Lucía E Núez Caroll J Beltrán Enzo Candia Cristóbal Suazo Manuel varez-Lobos María-Julieta González Marcela A Hermoso Rodrigo Quera | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 2 | Non-alcoholic fatty liver disease may not be a severe disease at presentation among Asian Indians显示文摘瞄准:与非含酒精的脂肝疾病(NAFLD ) 评估病人的临床、生物化学的侧面并且在表示估计他们的组织学的严厉。方法:介绍给所有印度的肝诊所的连续病人与提起的 transaminases 医学科学(AIIMS ) 开创到乘正常的上面的限制的至少 1.5,并且组织学地证实的非酒精的脂肝疾病被包括。或谁有重要白酒吸入或另外的肝疾病的积极标记的病人正在服知道生产脂肝的药被排除。这个组的临床、生物化学、组织学的侧面被学习。结果:有 NAFLD 的 51 个病人形成了学习人口。他们的中部的年龄和 BMI 是 34 (17-58 ) 年并且 26.7 (21.3-32.5 ) kg/m (2 ) 分别地并且(90.1%) 46 是男性。病人的多数有温和发炎,也分级 1 [32 (63%)] 或等级 2 [16 (31%)] 并且仅仅 3 (6%) 病人们有严重(等级 3 ) 发炎。23 (45%) , 19 (37%) , 8 (16%) 并且 1 (2%) 病人有 0, 1, 2 和 3 纤维变性分别地在索引活体检视和没有上有的舞台肝硬化。在 univariate 分析上,甘油三酸酯铺平超过 150 mg %( 或 = 7.1;95% CI:1.6-31.5, P = 0.002 ) 并且著名计算机生产厂商 / 中高音 ratio>1 (或 = 14.3;95% CI:1.4-678.5, P = 0.008 ) 与发炎的高等级被联系,任何一个都没与先进纤维变性被联系。在上多变量逻辑回归分析, hypertriglyceridemia >150 mg% 是独立地与发炎的高等级的存在联系的唯一的因素(或 = 1.6;95% CI:1.3-22.7, P = 0.02 ) ,当任何一个都没与先进纤维变性被联系时。甘油三酸酯层次与煽动性的等级断然相关(r = 0.412;P = 0.003 ) 。结论:在诺思印第安人病人的 NAFLD 是年轻超重男性,其中大多数是抵抗的胰岛素的疾病,他们趋于在表示有温和组织学的疾病。 | Kaushal Madan Yogesh Batra S Datta Gupta Bal Chander K D Anand Rajan M S Tewatia S K Panda S K Acharya | 2006 | World Journal of Gastroenterology2006，12，21： | 7 |
| 3 | One stop shop IV: taxonomic update with molecular phylogeny for important phytopathogenic genera: 76-100 (2020)显示文摘This is a continuation of a series focused on providing a stable platform for the taxonomy of phytopathogenic fungi and fungus-like organisms.This paper focuses on one family:Erysiphaceae and 24 phytopathogenic genera:Armillaria,Barrio-psis,Cercospora,Cladosporium,Clinoconidium,Colletotrichum,Cylindrocladiella,Dothidotthia,,Fomitopsis,Ganoderma,Golovinomyces,Heterobasidium,Meliola,Mucor,Neoerysiphe,Nothophoma,Phellinus,Phytophthora,Pseudoseptoria,Pythium,Rhizopus,Stemphylium,Thyrostroma and Wojnowiciella.Each genus is provided with a taxonomic background,distribution,hosts,disease symptoms,and updated backbone trees.Species confirmed with pathogenicity studies are denoted when data are available.Six of the genera are updated from previous entries as many new species have been described. | Ruvishika S.Jayawardena Kevin D.Hyde Yi Jyun Chen Viktor Papp Balázs Palla Dávid Papp Chitrabhanu S.Bhunjun Vedprakash G.Hurdeal Chanokned Senwanna Ishara S.Manawasinghe Dulanjalee L.Harischandra Ajay Kumar Gautam Shubhi Avasthi Boontiya Chuankid Ishani D.Goonasekara Sinang Hongsanan XiangYu Zeng Kapila K.Liyanage NingGuo Liu Anuruddha Karunarathna Kalani K.Hapuarachchi Thatsanee Luangharn Olivier Raspé Rashika Brahmanage Mingkwan Doilom Hyang B.Lee Liu Mei Rajesh Jeewon Naruemon Huanraluek Napalai Chaiwan Marc Stadler Yong Wang | 2020 | Fungal Diversity2020，，4： | 2 |
| 4 | DEM-based morphometry as a tool for reconstructing primary volcanic landforms:examples from the Borzsony Mountains,Hungary显示文摘 | Székely Balázs Dávid Karátson | 2004 | Geomorphology2004，63，： | 1 |
| 5 | Muscle oxygen uptake and energy turnover during dynamic exercise at different contraction frequencies in humans显示文摘 | Ferguson RA Bal D Krustrup P | | 0，，1： | 1 |
| 6 | Design,synthesis and biological evaluation of novel non-nucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum chemotherapeutic properties显示文摘 | SRIRAM D BAL T R YOGEESWARI P | 2004 | Bioorganic&Medicinal Chemistry2004，12，22： | 1 |
| 7 | A role for the Hsp90 molecular chaperone family in antigen presentation to T lymphocytes via major histocompatibility complex class II molecules显示文摘 | Rajagopal D Bal V Mayor S George A Rath S | 2006 | Eur J Immunol2006，36，4： | 1 |
| 8 | Neuroprotective effect of aspirin by inhibition of glutamate release after permanent focal cerebral ischemia in rats显示文摘 | De Cristóbal J Moro AM Dávalos A | | 0，，02： | 1 |
| 9 | Primary squamous-cell carcinoma of the thyroid gland:new evidence in support of follicular epithelial cell origin显示文摘 | Sahoo M Bal CS Bhatnagar D | 2002 | Diagn Cytopathol2002，27，4： | 1 |
| 10 | Noninvasive assessment of myocardial viability in a small animal model:comparison of MRI,SPECT,and PET显示文摘 | Thomas D Bal H Arkles J | | 0，，： | 1 |
| 11 | Fatal descending necrotizing mediastinitis secondary to acute suppurative thyroiditis developing in an apparently healthy woman 显示文摘 | PEREIRA O PRASAD D S BAL A M | 2010 | Thyroid2010，20，5： | 1 |
| 12 | Thermoluminescent dosimetry of the select seed 125I interstitial brachytherapy seed显示文摘 | An G Bal D Kar P | | 0，，05： | 1 |
| 13 | Primary squamous-cell carcinoma of the thyroid gland:new evidencein support of follicular epithelial cell origin显示文摘 | Sahoo M Bal CS Bhatnagar D | | 0，，04： | 1 |
| 14 | Impact of the matur ity of co rn for use as silage in the diets of dairy cow on intake, dig estio n and milk production显示文摘 | Bal M A Gcoors J G Shaver R D | 1997 | Journal of Dairy Science1997，，80： | 1 |
| 15 | Biological identifications through DNA barcodes显示文摘 | Hebert P D N Cywimska A Bal S L | 2003 | Biological Sciences/The Royal Society2003，270，1512： | 1 |
| 16 | Impact of the maturity of corn for use as silage in the diets of dairy cows on intake, digestion, and milk production 显示文摘 | Bal M A Coors J G Shaver R D | 1997 | J Dairy Sei1997，80，10： | 1 |
| 17 | Comments on the definition of the Q2 parameter for QSAR validation显示文摘 | Consonni V Bal abio D Todeschini R | | 0，，： | 1 |
| 18 | Primary squamous-cell carcinoma of the thyroid gland: New evidence in support of follicular epithelial cell origin显示文摘 | Bal CS Bhamagar D | 2002 | Diagn Cytopathol2002，27，4： | 1 |
| 19 | Toll-like receptor triggering of a vitamin D-media- ted human antimicrobial response 显示文摘 | Liu PT Stenger S Li H Wenzel L Tan BH Krutzik SR Ochoa MT Schauber J Wu K Meinken C Kamen DL Wagner M Bals R Steinmeyer A Ztigel U Gallo RL Eis- enberg D Hewison M Hollis BW Adams JS Bloom BR Modlin RL | 2006 | Science2006，311，： | 1 |
| 20 | A double-blind placebocontrolled study on prophylactic use of cisapride on feed intolerance and gastric emptying in preterm neonates 显示文摘 | Reddy PS Deorari AK Bal CS et d | 2000 | Indian Pediatr2000，37，8： | 1 |
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