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| 1 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 2 | Randomized phase Ⅱ B trial of BLP25 liposome vaccine in stage Ⅲ B and Ⅳ non-small cell lung cancer显示文摘 | Butts C Murray N Maksymiuk A | 2006 | J Clin Oncol2006，23，27： | 1 |
| 3 | Thermal stability of retained austenite in TRIP steels studied by synchrotron X-ray diffraction during cooling显示文摘 | Van Dijk N H Butt A M | 2005 | Acta Materialia2005，53，： | 1 |
| 4 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 5 | The impact of cruise ship generated waste on home ports and ports of call : A study of Southampton 显示文摘 | Butt N | 2007 | Marine Policy2007，31，5： | 1 |
| 6 | The impact of cruise ship generated waste on home ports and ports of call:a study of Southampton显示文摘 | BUTT N | 2007 | Marine Pol- icy2007，31，5： | 1 |
| 7 | High-intensity interval training may reduce in-stent restenusis following percutaneous coronary intervention with stent implantation:a randomized controlled trial evaluating the re- lationship to endothelial function and inflammation 显示文摘 | Munk PS Staal EM Butt N | 2009 | Am Heart J2009，158，5： | 1 |
| 8 | Daily iron supplementation is more effective than twice weekly iron supplementation in pregnant women in Pakistan in a randomized double-blind clinical trial显示文摘 | MUMTAZ Z SHAHAB S BUTT N | 2000 | J Nutr2000，130，11： | 1 |
| 9 | Methylene blue as an electrochemical discriminator of single- and double-stranded oligonudeotides immobilized on gold 显示文摘 | A Tani A J Thomson J N Butt | 2001 | Analyst2001，126，10： | 1 |
| 10 | Optimizing the highway lifetime by improving the self healing capacity of asphalt显示文摘 | Butt A A Birgisson B Kringos N | 2012 | Proc-Soc Behav Sci2012，48，： | 1 |
| 11 | Malignant esophagores phirastory fistula:management options and surrival 显示文摘 | Butt M Diehl W Maartini N | 1991 | Ann Thorac Surg1991，52，6： | 1 |
| 12 | Idiopathic adult ileoileal and ileocolic intussusception in situs inversus totalis: A rare coin- cidence 显示文摘 | Butt N Shah SH Alvi AR | 2012 | Saudi J Gastroentero2012，18，1： | 1 |
| 13 | The amphi- oxus genome and the evolutionof the chordate karyo- type显示文摘 | Putnam N H Butts T Ferrier D E K | 2008 | Nature2008，453，7198： | 1 |
| 14 | Grid-computing portals and security issues显示文摘 | BUTT A R ADABALA S KAPADIA N | 2003 | Journal of Parallel and Distributed Computing2003，63，10： | 1 |
| 15 | Diabetes mellitus and decompensated cirrhosis: risk of hepatic encephalopathy in different age groups显示文摘 | Zeeshan Butt Nauman A Jadoon Osman N Salaria et al | 2013 | Journal of diabetes2013，5，4： | 1 |
| 16 | 查看详情显示文摘 | Feltin E Carlin J F Dorsaz J Christmann G Butte R Latigt M Ilegems M Grandjean N | | 0，，： | 1 |
| 17 | Ileal intussusception secondary to small bowel metastases from melanoma显示文摘 | Jean M. Butte Manuel Meneses Enrique Waugh Hugo Parada Hernán De La Fuente | 2009 | The American Journal of Surgery2009，，1： | 1 |
| 18 | Countering radio frequency interference in single-sensor quadrupole resonance显示文摘 | SOMASUNDARAM S D JAKOBSSON A and BUTT N R | 2009 | IEEE Geoscience And Remote Sensing Letters2009，6，1： | 1 |
| 19 | Grid- computing portals and security issues 显示文摘 | BUTT A R ADABALA S KAPADIA N H | 2003 | Journal of Parallel and Distributed Computing2003，63，10： | 1 |
| 20 | The amphioxus genome and the evolution of the chordate karyotype显示文摘 | Putnam N H Blow M J Butts T | 2008 | Nature2008，453，19： | 1 |
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