|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cytotoxicity evaluation and hepatoprotective potential of bioassay guided fractions from Feronia limmonia Linn leaf显示文摘Objective:To evaluate the cytotoxicity and hepatoprotective potentials of extracts,fractions or isolated compound from the leaves of Feronia limonia(F.limonia).Methods:Qualitative phytochemical analysis of extracts,fractions or compound was performed by means of thin layer chromatography and spectroscopic assays.The%purity of compound was measured by analytical HPLC.Extracts,fractions or compound have been individually evaluated for their cytotoxicity effects(10,20,100,250,500,750 and 1 000 μg/mL).Based on the inhibitory concentration(IC_(50)) obtained from the cell viability assay,graded concentrations of extracts,fractions or isolated compound were assessed(10,20,50,100,200 μg/mL) for its hepatoprotective potential against CCl_4-induced hepatotoxicity by monitoring activity levels of serum glutamatic pyruvatic transaminase(SGPT) and serum glutamic oxaloacetic transaminase(SGOT).Results:Results indicated that the methanol extract of F.limonia was non-toxic and hepatoprotective in nature as compared with the petroleum ether extract.The acetone fraction of methanolic extract also showed similar properties but the subsequent two fractions were cytotoxic.However,the pure compound isolated from the penultimate fraction of methanolic extract was non-toxic and hepatoprotective in nature.Biochemical investigations(SCOT,SCPT) further corroborated these cytological observations.Conclusions:It can be concluded from this study that F.limonia methanol extract,some fractions and pure isolated compound herein exhibit hepatoprotective activity.However,cytotoxicity recorded in the penultimate fraction and investigation of structural details of pure compound warrants further study. | Mahendra Jain Rakhee Kapadia Ravirajsinh N Jadeja Menaka C Thounaojam Ranjitsinh V Devkar SH Mishra | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 11 |
| 2 | A theoretical model of themocapillary flows in laser welding显示文摘 | N Postacioglu P Kapadia J Dowden | 1991 | Appl Phys1991，24，1： | 1 |
| 3 | Kruppel-like factor 4 regu- lates macrophage polarization显示文摘 | Liao X Sharma N Kapadia F | 2011 | J Clin Invest2011，121，7： | 1 |
| 4 | Common failings:howcorporate defaults are correlated显示文摘 | DAS S DUFFIE D KAPADIA N SAITA L | 2007 | Journal of Finance2007，62，1： | 1 |
| 5 | Delta-hedged gains and the negative market volatility risk premium显示文摘 | Bakshi G Kapadia N | 2003 | Review of Financial Studies2003，16，2： | 1 |
| 6 | Grid-computing portals and security issues显示文摘 | BUTT A R ADABALA S KAPADIA N | 2003 | Journal of Parallel and Distributed Computing2003，63，10： | 1 |
| 7 | Grid- computing portals and security issues 显示文摘 | BUTT A R ADABALA S KAPADIA N H | 2003 | Journal of Parallel and Distributed Computing2003，63，10： | 1 |
| 8 | Krüppel-like factor 4 regulates macrophage polarization显示文摘 | Liao X Sharma N Kapadia F | 2011 | J Clin Invest2011，121，7： | 1 |
| 9 | Multimodalityimaging before, during, and after percutaneous mitral valverepair 显示文摘 | Delgado V Kapadia S Marsan N A | 2011 | Heart2011，97，20： | 1 |
| 10 | Gabapentin for chronic pain in spinal cord injury: a case report显示文摘 | Kapadia NP Harden N | 2000 | Arch Phys Med Rehabil2000，81，10： | 1 |
| 11 | Diagnostic accuracy of EUS in differentiating mucosal versus submucosal invasion of superficial esophageal cancers:a systematic review and meta-analysis显示文摘 | Thosani N Singh H Kapadia A | | 0，，02： | 1 |
| 12 | Kruppel - like factor 4 reg- ulates macrophage polarization 显示文摘 | Liao X Sharma N Kapadia F | 2011 | J Clin Invest2011，121，7： | 1 |
| 13 | Size and complexity in model financial systems显示文摘 | Arinaminpathy N Kapadia S May R | 2012 | Proceedings of the National Academy of Sciences2012，109，18： | 1 |
| 14 | Diagnostic accuracy of EUS in differentiating mucosal versus submucosal invasion of su- perficial esophageal cancers:a systematic review and meta- analysis 显示文摘 | Thosani N Singh H Kapadia A | 2012 | Gastrointest Endosc2012，75，2： | 1 |
| 15 | Hepatopro- tective potential of Tecomella undulata stem bark is par- tially due to the presence of betulinic acid显示文摘 | JAIN M KAPADIA R JADEJA R N | 2012 | Journal of ethnopharmacology2012，143，1： | 1 |
| 16 | Delta-hedged Gains and the Negative Market Volatility Risk Premium 显示文摘 | BAKSHI G KAPADIA N | 2003 | Review of Financial Studies2003，16，2： | 1 |
| 17 | An analysis of the laser-plasma interaction in laser keyhole welding显示文摘 | DOWDEN J M KAPADIA P POSTACIOGLU N | 1989 | J Phys D:Appl Phys1989，22，： | 1 |
| 18 | Feasibility and efficacy of upper limb robotic rehabilitation in a subacute cervical spinal cord injury population 显示文摘 | Zariffa J Kapadia N Kramer JLK | 2012 | Spinal cord2012，50，3： | 1 |
| 19 | Krüppel-like factor 4 regulates macrophage polarization显示文摘 | Liao X Sharma N Kapadia F | | 0，，07： | 1 |
| 20 | An analysis of the laser- plasma interaction in laser keyhole welding 显示文摘 | J Dowden P Kapadia N Postacioglu | 1989 | J Phys D: Appl Phys1989，22，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员