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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | The Mechanical Properties of Wear-resistant Coatings:I Modelling of Hardness Havior显示文摘 | Rickerby D S | 1987 | Thin Solid Film s1987，148，： | 1 |
| 3 | The relationship between hardness and scratch adhesion显示文摘 | Burnett P J Rickerby D S | 1987 | Thin Solid Films1987，154，： | 1 |
| 4 | Changing the surface mechanical properties of sillicon and α-Al2 O3 by ion implantation显示文摘 | Burnett P J Page T F | 1984 | Mater Sci1984，19，11： | 1 |
| 5 | Diagnosis and management of acute myeloid leukemia in adults:recommendations from an international expert panel,on behalf of the European LeukemiaNet显示文摘 | Dhner H Estey EH Amadori S Appelbaum FR Büchner T Burnett AK Dombret H Fenaux P Grimwade D Larson RA Lo-Coco F Naoe T Niederwieser D Ossenkoppele GJ Sanz MA Sierra J Tallman MS Lwenberg B Bloomfield CD | 2010 | {H}Blood2010，，03： | 1 |
| 6 | The emerging role of targeted therapy for hematologic maligncies: update on bortezomib and tipifarnib 显示文摘 | ARMAND J P BURNETT A K DRACH J | 2007 | Oncologist2007，12，： | 1 |
| 7 | The relationship between hardness and scratch adhession显示文摘 | BURNETT P J RICKERB D S | 1987 | Thin Solid Films1987，154，1： | 1 |
| 8 | Polychlorinatedbiphenyls (PCBs)in the British environment:Sinks,sources and temporal trends显示文摘 | Harrad S J Sewart A P Alcock R Boumphrey R Burnett V Davidson R D Halsall C Sanders G Waterhouse K | 1994 | Environmental Pollution1994，85，： | 1 |
| 9 | Use of plasma brain natriuretic peptide concentration to aid in the diagnosis of heart failure显示文摘 | SHAPIRO B P CHEN H H BURNETT J C Jr | 2003 | Mayo Clin Proc2003，78，： | 1 |
| 10 | Associations between abortion, mental disorders, and suicidal behavior in a nationally representative sample 显示文摘 | Mota N P Burnett M Sareen J | 2010 | Can J Psychiatry2010，55，4： | 1 |
| 11 | Field evaluation of seepage meters in the coastal marine environment 显示文摘 | CABLE J E BURNETT W C CHANTON J P | 1997 | Estuarine Coastal and Shelf Science1997，45，3： | 1 |
| 12 | Real-Time Bose-Einstein condensationin a finite volume with a discrete spectrum 显示文摘 | RUPRECHT P A HOLLAND M J BURNETT K | 1995 | Ibid1995，51，3： | 1 |
| 13 | Detection, biological ef- fects, and transmission of a virus of the aphid Rhopalosiphum padi显示文摘 | D'Arcy C J Burnett P A Hewings A D | 1981 | Virology1981，114，1： | 1 |
| 14 | Lysine-Arginine electrolyte relationships in the rat显示文摘 | Jones J D Wolters R Burnett P C | 1966 | The Journal of Nutrition1966，89，2： | 1 |
| 15 | The mechanism of the lysine-arginine atagonism in the chick : Effect of lysine on digestion, kidney arginase, and liver transamidinase显示文摘 | Jones J D Petersburg S J Burnett P C | 1967 | The Journal of Nutrition1967，93，1： | 1 |
| 16 | Use of plasma brain natriuretic peptide concentration to aid in the diagnosis of heart failure显示文摘 | SHAPIRO B P CHEN H H BURNETT J J | 2003 | Mayo Clin Proc2003，78，4： | 1 |
| 17 | A prospective randomized clinical trial of patellar resurfa cing and nonresurfacing in bilateral TKA显示文摘 | Burnett R S Boone J L McCarthy K P Rosenzweig S Barrack R L | 2007 | Clin Orthop Relat Res2007，，： | 1 |
| 18 | Ra- tionale and design of a randomized,double-blind,placebo- controlled clinical trial to evaluate the efficacy of B-type natri- uretic peptide for the preservation of left ventricular function after anterior myocardial infarction显示文摘 | Sangaralingham SJ Burnett J C Jr McKie P M | 2013 | J Card Fail2013，19，8： | 1 |
| 19 | Solar wind neon from genesis: Implications for the lunar noble gas record 显示文摘 | Grimberg A Baur H Bochsler P Buhler F Burnett D S Hays C C Heber V S Jurewicz A J G Wieler R | 2006 | Science2006，314，5802： | 1 |
| 20 | FieldEvaluation of Seepage Meters in the Coastal MarineEnvironment 显示文摘 | CABLE J E BURNETT W C CHANTON J P | 1997 | Estuarine Coastal and Shelf Science1997，45，3： | 1 |
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