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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | Potential future therapies: natriuretic peptides 显示文摘 | BURNETT J C Jr | 1999 | Coron Artery Dis1999，10，9： | 1 |
| 3 | Echocardiography oftranstrial embolism during cemented and uncemented hemiartheroplasty of the hip显示文摘 | Burnett R PottsH R etal | 1994 | J Bone Joint Surg Br1994，76，3： | 1 |
| 4 | The Mechanical Properties of Wear-resistant Coatings:I Modelling of Hardness Havior显示文摘 | Rickerby D S | 1987 | Thin Solid Film s1987，148，： | 1 |
| 5 | Association between particulate and gas-phase components of urban air pollution and daily mortality in eight Canadian cities显示文摘 | Burnett RT Brook J Dann T | | Inhal Toxicol0，12，： | 1 |
| 6 | Lung cancer,cardiopulmonary mortality and long-term exposure to fineparticulate air pollution显示文摘 | Pope C A Burnett R T Thun M J | 2002 | Journal of the American MedicalAssociation2002，287，9： | 1 |
| 7 | Association between particulate-and gas-phase components of urban air pollution and daily mortality in eight Canadian cities显示文摘 | BURNETT R T BROOK J DANN T | 2000 | Inhal Toxicol2000，12，4： | 1 |
| 8 | A study on the energy performance of three schemes for widening application of water-cooled air-conditioning systems in Hong Kong显示文摘 | Yik FWH Burnett J Prescott I | 2001 | Energy and Buildings2001，33，2： | 1 |
| 9 | Knowledge based product life cycle systems:principles of integration of KBE and C3P显示文摘 | Penoyer J A Burnett G Fawcett D J | 2000 | Computer-Aided Design2000，32，： | 1 |
| 10 | The relationship between hardness and scratch adhesion显示文摘 | Burnett P J Rickerby D S | 1987 | Thin Solid Films1987，154，： | 1 |
| 11 | Short-term clinical effects of tolvaptan,an oral vasopressin antagonist,in patients hospitalized for heart failure:the EVEREST Clinical Status Trials显示文摘 | Gheorghiade M Konstam M A Burnett J J | 2007 | JAMA2007，297，12： | 1 |
| 12 | Vasopeptidase inhibitors: a new therapeutic concept in cardiovascular disease? 显示文摘 | BURNETT J C Jr RORLEAU J L | 2001 | Circulation2001，104，15： | 1 |
| 13 | A Strategic Approach to Managing Crises 显示文摘 | Burnett J J | 1998 | Public Relations Review1998，，24： | 1 |
| 14 | Knowledge Based Product Life Cycle Systems: Princip Les of Integration of KBE and C3P 显示文摘 | PENOYER J A BURNETT G FAWCETT D J | 2000 | Computer-Aided Design2000，32，： | 1 |
| 15 | Changing the surface mechanical properties of sillicon and α-Al2 O3 by ion implantation显示文摘 | Burnett P J Page T F | 1984 | Mater Sci1984，19，11： | 1 |
| 16 | Diagnosis and management of acute myeloid leukemia in adults:recommendations from an international expert panel,on behalf of the European LeukemiaNet显示文摘 | Dhner H Estey EH Amadori S Appelbaum FR Büchner T Burnett AK Dombret H Fenaux P Grimwade D Larson RA Lo-Coco F Naoe T Niederwieser D Ossenkoppele GJ Sanz MA Sierra J Tallman MS Lwenberg B Bloomfield CD | 2010 | {H}Blood2010，，03： | 1 |
| 17 | Support for investigator-initiated clinical research involving investigational drugs or devices:the clinical and translational science award experience显示文摘 | Berro M Burnett BK Fromell J | | 0，，02： | 1 |
| 18 | Current progress of siRNA/shRNA therapeutics in clinical trials显示文摘 | Burnett J C Rossi J J Tiemann K | 2011 | Biotechnol J2011，6，9： | 1 |
| 19 | Adult xpl 1 translocation associated renal cell carcinoma: Time to recognize 显示文摘 | Klaassen Z Tatem A Burnette J | 2012 | Urology2012，80，5： | 1 |
| 20 | Cross-sectional associations of resistin, coro nary heart disease, and insulin resistance显示文摘 | BURNETT M S DEVANEY J M ADENIKA R J | 2006 | J Clin Endocrinol Metab2006，91，： | 1 |
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