5篇
您的检索式：作者名="BRESLIN Peter"
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| 1 | Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is a very deadly disease.HCC initiation and progression involve multiple genetic events,including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes.Activation of oncogenes stimulates cell growth and survival,while loss-of-function mutations of tumor suppressor genes result in unrestrained cell growth.In this review,we summarize the new findings that identified novel proto-oncogenes and tumor suppressors in HCC over the past five years.These findings may inspire the development of novel therapeutic strategies to improve the outcome of HCC patients. | Fang Wang Peter Breslin S J Wei Qiu | 2021 | Liver Research2021，5，4： | 3 |
| 2 | Seed oil of Brucea javanica induces apoptosis through the PI3K/Akt signaling pathway in acute lymphocytic leukemia Jurkat cells显示文摘Brucea javanica oil emulsion(BJOE)has been used to treat tumor in China for more than 40 years.However,its components and effectiveness in the treatment of acute lymphocytic leukemia(ALL)and its mechanism of anti-cancer activity remain unknown.In the current study,high-performance liquid chromatography-evaporative light scattering detector(HPLC-ELSD)was used to analyze the components of BJOE.Then,the anti-leukemia effects of BJOE were examined both in vitro and in vivo using ALL Jurkat cells and the p388 mouse leukemia transplant model,respectively.The primary ALL leukemia cells were also used to confirm the antileukemia effects of BJOE.The apoptotic-related results indicated that BJOE induced apoptosis in Jurkat cells and were suggestive of intrinsic apoptotic induction.Moreover,BJOE inhibited Akt(protein kinase B)activation and upregulated its downstream targets p53 and Fox O1(forkhead box gene,group O-1)to initiate apoptosis.The activation of GSK3βwas also involved.Our findings demonstrate that BJOE has anti-leukemia effects on ALL cells and can induce apoptosis in Jurkat cells through the phosphoinositide3-kinase(PI3 K)/Akt signaling pathway. | ZHANG Hong YIN Shi-Liang WANG Li-Hui JIA Li-Na SU Guang-Yue LIU Xiao-Qing ZHOU Fan BRESLIN Peter MENG Ran LI Qi-Yi YANG Jing-Yu WU Chun-Fu | 2021 | Chinese Journal of Natural Medicines2021，19，8： | 2 |
| 3 | Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases显示文摘像使用费的受体(TLR ) 在天生的有免疫力的房间被发现,响应感染和织物损坏是快速的煽动性的回答和适当 T 房间激活的必要调停人。积累的证据建议发信号的 TLR 涉及正常造血作用和特定的 hematologic 病理。特别 TLR 和他们的下游的发信号调停人不仅在严重地区分的天生的有免疫力的房间而且在早造血的祖先被表示。TLR 发信号的无菌的激活被要求产生早胚胎的造血的祖先房间。在成年动物,直接或间接地发信号的 TLR 在感染和织物损坏期间在损坏淋巴的房间和造血的干细胞的自强的的情况下支持 myeloid 房间的区别。MyD88 基因的激活的变化,为涉及 TLR 的一个关键适配器编码发信号,是通常在 B 房间检测了淋巴瘤和另外的 B 房间 hematopathologies。发信号的 Dysregulated TLR 贡献许多造血的混乱的致病,包括骨头髓失败, myelodysplastic 症候群,和尖锐 myeloid 白血病。完成正常、病原的造血作用的规定将为造血的混乱的改进处理证明珍贵到指向的治疗和策略的发展的发信号的 TLR 由调停的分子的机制的说明。 | Joseph Cannova | 2015 | Frontiers of Medicine2015，9，3： | 2 |
| 4 | Neoadjuvant Chemoradiotherapy for Adenocarcinoma of the Pancreas: Treatment Variables and Survival Duration显示文摘 | Tara M. Breslin MD Kenneth R. Hess PhD Dana B. Harbison MD Marina E. Jean MD Karen R. Cleary MD Alan P. Dackiw MD Robert A. Wolff MD James L. Abbruzzese MD Nora A. Janjan MD Christopher H. Crane MD J. Nicolas Vauthey MD Jeffrey E. Lee MD Peter W. T. Piste | 2001 | Annals of Surgical Oncology2001，，2： | 1 |
| 5 | Neoadjuvant Chemoradiotherapy for Adenocarcinoma of the Pancreas: Treatment Variables and Survival Duration显示文摘 | Tara M. Breslin MD Kenneth R. Hess PhD Dana B. Harbison MD Marina E. Jean MD Karen R. Cleary MD Alan P. Dackiw MD Robert A. Wolff MD James L. Abbruzzese MD Nora A. Janjan MD Christopher H. Crane MD J. Nicolas Vauthey MD Jeffrey E. Lee MD Peter W. T. Piste | 2001 | Annals of Surgical Oncology2001，，2： | 1 |
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