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| 1 | Implication of the intestinal microbiome in complications of cirrhosis显示文摘The intestinal microbiome(IM) is altered in patients with cirrhosis,and emerging literature suggests that this impacts on the development of complications.The Pub Med database was searched from January 2000 to May 2015 for studies and review articles on the composition,pathophysiologic effects and therapeutic modulation of the IM in cirrhosis.The following combination of relevant text words and MeS H terms were used,namely intestinal microbiome,microbiota,or dysbiosis,and cirrhosis,encephalopathy,spontaneous bacterial peritonitis,hepatorenal syndrome,variceal bleeding,hepatopulmonary syndrome,portopulmonary hypertension and hepatocellular carcinoma.The search results were evaluated for pertinence to the subject of IM and cirrhosis,as well as for quality of study design.The IM in cirrhosis is characterized by a decreased proportion of Bacteroides and Lactobacilli,and an increased proportion of Enterobacteriaceae compared to healthy controls.Except for alcoholic cirrhosis,the composition of the IM in cirrhosis is not affected by the etiology of the liver disease.The percentage of Enterobacteriaceae increases with worsening liver disease severity and decompensation and is associated with bacteremia,spontaneous bacterial peritonitis and hepatic encephalopathy.Lactulose,rifaximin and Lactobacillus-containing probiotics have been shown to partial y reverse the cirrhosis associated enteric dysbiosis,in conjunction with improvement in encephalopathy.The IM is altered in cirrhosis,and this may contribute to the development of complications associated with end-stage liver disease.Therapies such as lactulose,rifaximin and probiotics may,at least partially,reverse the cirrhosisassociated changes in the IM.This,in turn,may prevent or alleviate the severity of complications. | Mamatha Bhat Bianca M Arendt Venkat Bhat Eberhard L Renner Atul Humar Johane P Allard | 2016 | World Journal of Hepatology2016，8，27： | 13 |
| 2 | 血管紧张素转换酶抑制剂和血管紧张素受体拮抗剂的使用与2019冠状病毒疾病检测阳性之间的关系显示文摘血管紧张素转换酶抑制剂(angiotensin-converting enzyme inhibitor,ACEI)和血管紧张素受体拮抗剂(angiotensin receptor blocker,ARB)在2019新型冠状病毒疾病(coronavirus disease 2019,COVID-19)全球大流行背景下的作用备受争议。此类药物是治疗一些慢性病的必须药物,有建议停止使用这些药物. | Mehta N KalraA Nowacki AS Anjewierden S Han Z Bhat p Rubio AEC Jacob M Procop GW Harrington S Milinovich A Svensson LG Jehi L Young JB Chung MK 周卫(译) 叶鹏(校) | 2020 | 中华高血压杂志2020，28，5： | 9 |
| 3 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 4 | Heave plate design with computational fluid dynamics 显示文摘 | Holmes S Bhat S Beynet P | 2001 | Journal of Offshore Mechanics and Artic Engineering2001，123，1： | 1 |
| 5 | Lactation curve in Malabari goats and their Saanen half-breds显示文摘 | MUKUNDAN G BHAT P N | 1983 | Indian Journal of Animal Sciences1983，53，： | 1 |
| 6 | Precise Point to Point Positioning Control of Flexible Structure显示文摘 | Bhat S P Miu D K | 1990 | ASME J of Dynamic System Measurement and Control1990，112，4： | 1 |
| 7 | Output-feedback semiglobal stabilization of stall dynamics for preventing hysteresis and surge in axial-flow compressors显示文摘 | CHATURVEDI N A BHAT S P | 2006 | IEEE Trans Control Syst Technol2006，14，2： | 1 |
| 8 | In-situ technique for synthesizing Fe-TiC composites 显示文摘 | Raghunath C Bhat M S Rohagi P K | 1995 | Scripta Metallurgica Materialia1995，，4： | 1 |
| 9 | Finite-time stability of continuous autonomous systems显示文摘 | Bhat S P Bernstein D S | 2000 | SIAM Journal of Control and Optimization2000，38，8： | 1 |
| 10 | Efficient Prins cyclization in environmentally benign method using ion exchange re- sin catalyst显示文摘 | More G P Rane M Bhat S V | 2012 | Green Chem Lett Rev2012，5，1： | 1 |
| 11 | Chemotherapy of fungus infections:Part II-Aliphatic& aromatic acid hydra zones and alkyl or aryl thiosemicarbazones of 5-chloro salicylaldehyde显示文摘 | Bhat AK Bhamaria R P Bellare RA | 1967 | Indian J Chem1967，5，： | 1 |
| 12 | Effect of Process Parameters on the Densification of 2024Al-20vol% SiCp Composites Fabricated by Explosive Compaction 显示文摘 | Bhat T B Ramakrishnan P | 1998 | J Mater Process Tech1998，73，： | 1 |
| 13 | Regulation andlocalization of tyrosine216 phosphorylation of glycogen synthasekinase-3 p in cellular and animal models of neuronal degeneration显示文摘 | Bhat R V Shanley J Correll M P | 2000 | Proc Natl Acad Sci USA2000，97，11： | 1 |
| 14 | Cytokine induction of induc- ible nitric oxide synthase in an oligodendrocyte cell line:role of p38 mitogen-activated protein kinase activation显示文摘 | BHAT N ZHANG P BHAT A | 1999 | J Neu- rochem1999，72，： | 1 |
| 15 | The protein data bank显示文摘 | Berman H M Westbrook J Feng Z K Gilliland G Bhat T N Weissig H Shindyalov L N Bourne P E | | 0，，01： | 1 |
| 16 | Continuous finite-time stabilization of the translational and rotational double integrators显示文摘 | Bhat S P Bernstein D S | 1998 | IEEE Transactions on Automatic Control1998，43，5： | 1 |
| 17 | Shear characteristics of soil -gravel mixtures 显示文摘 | Doddiah D Bhat H S Somasekhar P V | 1969 | Journal of the Indian National Society of Soil Mechanicsand Foundations Engineering1969，8，1： | 1 |
| 18 | Continuous finite-time stabilization of the translational and rotational double integrators 显示文摘 | Bhat S P Bernstein D S | 1998 | IEEE Transactions on Automatic Control1998，43，5： | 1 |
| 19 | Intracervical versus vaginal misoprostol for cervical dilatation prior to operative hys- teroscopy-a comparative study显示文摘 | GOYAL B ROY P BHAT P | 2012 | Med J Armed Forces India2012，68，2： | 1 |
| 20 | Aromatase inhibitors from Broussonetia papyrifera 显示文摘 | Lee D Bhat K P L Fong H H S | 2001 | Journal of Natural Products2001，64，： | 1 |
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