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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Regulation of car- diac innervation and function via the p75 neurotrophin recep- tor显示文摘 | Beth A H Parizad B Camille L | 2008 | Auton Neurosci2008，140，12： | 1 |
| 3 | TMS1,a novel pro-apoptotic caspase recruitment domain protein,is a target ofmethylation-induced gene silencing in human breast cancers显示文摘 | Kerry E C Beth/M Claire E B | 2000 | Cancer Res2000，60，22： | 1 |
| 4 | Clinical Cate/C, Poljak Zvonimir/ signs and their associa- tion with herd demographics and porcine re- productive and respiratory syndrome (PRRS) control strategies in PRRS PCR-positive swine herds in Ontario显示文摘 | Young Beth/B Dewey Z | 2010 | PLoS One2010，4，3： | 1 |
| 5 | Predictors of suicide attempts:state and trait components显示文摘 | DAVID B BETH A | 2006 | Journal of Abnormal Psychology2006，115，4： | 1 |
| 6 | Computational and experimental study of axisymmetric coflow partially premixed methane/air flames显示文摘 | Beth A V B Charles S M Lisa D P | 2000 | Combustion and Flame2000，123，4： | 1 |
| 7 | Reference librarians at the reference desk in a learning commons : a mixed methods evaluation 显示文摘 | Elizabeth B Fitzpatrick Anne C Moore Beth W Lang | | The0，200，3： | 1 |
| 8 | Improvement of the composting time for household waste during an initial low pH phase by mesophilic temperature control显示文摘 | Srnars S Gustafsson L Beth - Friis B | 2002 | Bioresource Technology2002，84，： | 1 |
| 9 | Who will Care for Us? Aging and Long-term Care in Multicultural America显示文摘 | Beth B Hess | 1997 | Contemporary Sociology1997，76，77： | 1 |
| 10 | Trust-based navigation in distributed systems显示文摘 | Yahalom R Klein B Beth T | 1994 | Journal of Computing Systems1994，，： | 1 |
| 11 | Big effects from smallchanges: possible ways to explore nature's chemical diversity显示文摘 | Bode H B Bethe B H6fs R | 2002 | Chembiochem2002，3，7： | 1 |
| 12 | Organizational citizenship behaviors:a critical review of the theoretical and empirical literature and suggest ions for future research显示文摘 | Podsakoff P M Mac Kenzie S B Julie Beth Paine | 2000 | Journal of Management2000，，3： | 1 |
| 13 | Role of preoperative ultrasonography in the surgical management of patients with thyroid cancer显示文摘 | Maria A Kouvaraki Suzanne E Shapiro Bruno D Fornage Beth S Edeiken-Monro Steven I Sherman Rena Vassilopoulou-Sellin Jeffrey E Lee Douglas B Evans | 2003 | Surgery2003，，6： | 1 |
| 14 | Guidelines for Evaluation and Registering cemeteries and Burial Places显示文摘 | Elisabeth W P Beth M B | 1992 | National register bulletin1992，，41： | 1 |
| 15 | Organizational citizenship behaviors: a critical review of the theoretical and empirical literature and suggestions for future research显示文摘 | Philip M Podsakoff Scott B MacKenzie Julie Beth Paine Daniel G Bachrach | 2000 | Journal of Management2000，，3： | 1 |
| 16 | Quebeda-clerkin,neuron-specific enolase,but Not S100B or myelin basic protein,increases in peripheral blood corresponding to lesion volume after cortical impact in piglets显示文摘 | Beth A Costine Patricia B | 2012 | Neurotrauma2012，29，17： | 1 |
| 17 | Taxes and Firm Size:The Effect of Tax Leg- islation During the 1980s显示文摘 | Beth B Kern Michael H Morris | 1991 | The Journal of the American Taxation Associa- tion1991，，12： | 1 |
| 18 | Comparative genomics of Helicobacter pylori:analysis of the outer membrane protein families显示文摘 | Richard AA James B Beth M | 2000 | Infection and Immunity2000，68，7： | 1 |
| 19 | Comparative genomics of Helicobacter pylori: analysis of the outer membrane protein families显示文摘 | Richard AA James B Beth M | 2000 | Infect Immun2000，68，7： | 1 |
| 20 | An adaptive FEA method to predict surface quality in hard machining显示文摘 | WEN Q GUO Y B TODD Beth A | 2006 | Journal of Materials Processing Technology2006，，173： | 1 |
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