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| 1 | Impact of sodium glucose cotransporter-2 inhibitors on liver steatosis/fibrosis/inflammation and redox balance in non-alcoholic fatty liver disease显示文摘BACKGROUND Sodium glucose cotransporter-2 inhibitors(SGLT2-I)are the most recently approved drugs for type 2 diabetes(T2D).Recent clinical trials of these compounds reported beneficial cardiovascular(CV)and renal outcomes.A major cause of vascular dysfunction and CV disease in diabetes is hyperglycemia associated with inflammation and oxidative stress.Pre-clinical studies demonstrated that SGLT2-I reduce glucotoxicity and promote anti-inflammatory effects by lowering oxidative stress.AIM To investigate the effects of SGLT2-I on markers of oxidative stress,inflammation,liver steatosis,and fibrosis in patients of T2D with non-alcoholic fatty liver disease(NAFLD).METHODS We referred fifty-two consecutive outpatients treated with metformin monotherapy and exhibiting poor glycemic control to our centre.We introduced the outpatients to an SGLT2-I(dapagliflozin,empagliflozin,or canagliflozin;n=26)or a different hypoglycemic drug[other glucose-lowering drugs(OTHER),n=26].We evaluated circulating interleukins and serum hydroxynonenal(HNE)-or malondialdehyde(MDA)-protein adducts,fatty liver index(FLI),NAFLD fibrosis score,aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,AST-to-platelet-ratio index(APRI),and fibrosis-4 on the day before(T0)and following treatment for six months(T1).We also performed transient elastography at T0 and T1.RESULTS Add-on therapy resulted in improved glycemic control and reduced fasting blood glucose in both groups.Of note,following treatment for six months,a reduction of FLI and APRI,as well as of the FibroScan result,was reported in patients treated with SGLT2-I,but not in the OTHER group;furthermore,in the SGLT2-I group,we reported lower circulating levels of interleukin(IL)-1β,IL-6,tumor necrosis factor,vascular endothelial growth factor,and monocyte chemoattractant protein-1,and higher levels of IL-4 and IL-10.We did not observe any modification in circulating interleukins in the OTHER group.Finally,serum HNE-and MDA-protein adducts decreased significantly in SGLT2-I rather than OTHER patients and correlated with liver steatosis and fibrosis scores.CONCLUSION The present data indicate that treatment with SGLT2-I in patients with T2D and NAFLD is associated with improvement of liver steatosis and fibrosis markers and circulating pro-inflammatory and redox status,more than optimizing glycemic control. | Francesco Bellanti Aurelio Lo Buglio MichałDobrakowski Aleksandra Kasperczyk Sławomir Kasperczyk Palok Aich Shivaram P Singh Gaetano Serviddio Gianluigi Vendemiale | 2022 | World Journal of Gastroenterology2022，28，26： | 3 |
| 2 | Perspectives on allergic rhinitis and its treatment显示文摘 | BELLANTI JA SETTIANE RA | 2013 | Allergy Asthma Proc2013，34，6： | 1 |
| 3 | Targeting mitochondria: a new promising approach for the treatment of liver diseases 显示文摘 | Serviddio G Bellanti F Sastre J | 2010 | Current Medicinal Chemistry2010，17，22： | 1 |
| 4 | Mitochondrial involvement in non-alcoholic steatohepatitis 显示文摘 | SERVIDDIO G SASTRE J BELLANTI F | 2008 | Mol Aspects Med2008，29，12： | 1 |
| 5 | Mitochondrial involvement in non-alcoholic steatohepatitis 显示文摘 | Serviddio G Sastre J Bellanti F | 2008 | Mol Aspects Med2008，29，12： | 1 |
| 6 | Recurrent respiratory tract infections in paediatric patients显示文摘 | Bellanti JA | 1997 | Drugs1997，54，1： | 1 |
| 7 | Mitochondrial oxidative stress and respiratory chain dysfunction account for liver toxicity during amiodarone but not dronedarone administration显示文摘 | Gaetano Serviddio Francesco Bellanti Anna Maria Giudetti Gabriele Vincenzo Gnoni Nazzareno Capitanio Rosanna Tamborra Antonino Davide Romano Maurizio Quinto Maria Blonda Gianluigi Vendemiale Emanuele Altomare | 2011 | Free Radical Biology and Medicine2011，，12： | 1 |
| 8 | Mitochondrialinvolvement in no- alcoholic steatohepatitis 显示文摘 | SERVIDDIO G SASTRE J BELLANTI F etal | 2008 | Mol As-pects Med2008，29，3： | 1 |
| 9 | The Quality of Sibling Relationships andthe Development of Social Competence and Behavioral Control in Aggressive Children显示文摘 | Stormshak E A Bellanti C J Bierman K | 1996 | Developmental Psychology1996，32，： | 1 |
| 10 | Mitochondrial involvement in non-alcoholic steatohepatitis显示文摘 | SERVIDDIO G SASTRE J BELLANTI F | | 0，，1： | 1 |
| 11 | Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury显示文摘 | Serviddio G Bellanti F Tamborra R | 2008 | Gut2008，57，7： | 1 |
| 12 | Quality of life issues ranging from the burden of ocular and nasal allergies to the anxiety associated with having to carry self-injectable epinephrine for insect sting allergy显示文摘 | Bellanti JA Settipane RA | 2014 | Allergy Asthma Proc2014，35，3： | 1 |
| 13 | Many faces of mitochondrial un- coupling during age: damage or defense 显示文摘 | Bellanti F Romano AD Giudetti AM | 2013 | J Gerontol A Biol Sci Med Sci2013，68，8： | 1 |
| 14 | Atopic Dermatitis, Genetics, Immunology and T regulatory cells显示文摘 | Bellanti JA Settipane RA | 2007 | Allergy Asthma Proc2007，28，： | 1 |
| 15 | IgE and non-IgE food allergy显示文摘 | Sabra A Bellanti JA Rais JM | 2003 | Ann Allergy Asthma Immunol2003，90，63： | 1 |
| 16 | Uncoupling protein-2(UCP2)induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis(NASH)liver to ischaemia-reperfusion injury显示文摘 | Serviddio G Bellanti F Tamborra R | | 0，，07： | 1 |
| 17 | Allergic rhinitis update: epidemiology and natural history显示文摘 | Wallerstedt DB | 2000 | Allergy Asthma Proc2000，21，6： | 1 |
| 18 | Recurrent respiratory tract infections in paediatric patients 显示文摘 | Bellanti JA | 1997 | Drugs1997，54，： | 1 |
| 19 | IgE and non-IgE food allergy 显示文摘 | Sabra A Bellanti JA Rais JM | 2003 | Ann Allergy Asthma Immuno12003，90，： | 1 |
| 20 | Mitochondrial oxidative stress and respiratory chain dysfunction account for liver toxicity during amiodarone but not dronedarone administration显示文摘 | Gaetano Serviddio Francesco Bellanti Anna Maria Giudetti Gabriele Vincenzo Gnoni Nazzareno Capitanio Rosanna Tamborra Antonino Davide Romano Maurizio Quinto Maria Blonda Gianluigi Vendemiale Emanuele Altomare | 2011 | Free Radical Biology and Medicine2011，，12： | 1 |
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