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| 1 | Metabolite profile comparisons between ascending and descending colon tissue in healthy adults显示文摘BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese adults.AIM To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk.METHODS Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite profiles.The colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal cancer.RESULTS Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass index.Amino acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite profiles.Normal weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending colon.Primary and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese adults.CONCLUSION There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy adults.Colon lipids and other metabolites in obese and overweight adults were distinguished from normal weight participants and associated with gut inflammation,nutrient absorption,and products of microbiota metabolism. | Bridget A Baxter Kristopher D Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan | 2020 | World Journal of Gastroenterology2020，26，3： | 2 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning显示文摘 | Ferdinandy P Schulz R Baxter GF | 2007 | Pharmacol Rev2007，59，4： | 1 |
| 4 | Colour Doppler ultrasound in deep venous thrombosis:a comparison with venography显示文摘 | Baxter GM Mckechnie S Dully P | 1990 | Clin Radiol1990，42，： | 1 |
| 5 | Detection of chloramphenicol and chloramphenicol glucuronide residues in poultry muscle,honey,prawn and milk using a surface plasmon resonance biosensor and Qflex kit chloramphenicol显示文摘 | Ferguson J Baxter A Young P | 2005 | Anal Chim Acta2005，529，： | 1 |
| 6 | The current and future applications of microorganism in the bioremediation of cyanide contamination 显示文摘 | BAXTER J CUMMINGS S P | 2006 | Antonie van Leeuwenhoek2006，90，1： | 1 |
| 7 | Frequency selectivity, multistability, and oscillations emerge from models ofgenetic regulatory systems显示文摘 | SMOLEN P BAXTER D A BYRNE J H | 1998 | Amer J Phys1998，274，： | 1 |
| 8 | Biosensor assay of sulfadiazine and sulfamethazine residues in pork 显示文摘 | Bjurling P Baxter G A Caselunghe M | 2000 | Analyst2000，125，10： | 1 |
| 9 | Surgical parathyroidectomy versus cinacalcet therapy: in the management of secondary hy- perparathyroidism显示文摘 | ghaai A Baxter P | 2011 | Otolaryngol Head Neck Surg2011，0，： | 1 |
| 10 | Surgical parathyroidectomy versus cina- calcet therapy: In the management of secondary hyperpara- thyroidism显示文摘 | Ghani A Baxter P | 2012 | Otolaryngol Head Neck Surg2012，146，2： | 1 |
| 11 | Mathematical modeling of gene networks review显示文摘 | Smolen P Baxter D A Byme J H | 2000 | Neuron2000，26，： | 1 |
| 12 | Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders 显示文摘 | BAXTER E J SCOTT L M CAMPBELL P J | 2005 | Lancet2005，365，： | 1 |
| 13 | Evaluation of Procedure-Based Scoring for Hands-On Science Assessment显示文摘 | Baxter G P Shavelson R J Goldman S R | | 0，，01： | 1 |
| 14 | Colour doppler ultra-sound in deep venous thrombosis:a comparison with venography显示文摘 | BAXTER G M MCKECHNIE S Dully P | 1990 | Clin Radiol1990，，42： | 1 |
| 15 | Diagnosing epilepsy 显示文摘 | Baxter P | 2006 | Dev Med Child Neurol2006，48，5： | 1 |
| 16 | Paediatric neurology: a year of DNA technology显示文摘 | Dan B Baxter P | 2014 | Lancet Neurol2014，13，： | 1 |
| 17 | Idiopathic catastrophic epileptic encephalopathy presenting with acute onset intractable status显示文摘 | Baxter P Clarke A Cross H | 2003 | Seizure2003，12，： | 1 |
| 18 | Epilepsy and sleep 显示文摘 | Baxter P | 2005 | Dev Med Child Neurol2005，47，11： | 1 |
| 19 | Leverage,Risk of Ruin and Cost of Capital显示文摘 | BAXTER P | 1967 | Journal of Finance1967，22，3： | 1 |
| 20 | Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders显示文摘 | Baxter E J Scott L M Campbell P J | | 0，，： | 1 |
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