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| 1 | Role of gut microbiota-immunity axis in patients undergoing surgery for colorectal cancer:Focus on short and long-term outcomes显示文摘Human body is colonized by a huge amount of microorganisms mostly located in the gastrointestinal tract.These dynamic communities,the environment and their metabolites constitute the microbiota.Growing data suggests a causal role of a dysbiotic microbiota in several pathologies,such as metabolic and neurological disorders,immunity dysregulations and cancer,especially the well-studied colorectal cancer development.However,many were preclinical studies and a complete knowledge of the pathogenetic mechanisms in humans is still absent.The gut microbiota can exert direct or indirect effects in different phases of colorectal cancer genesis.For example,Fusobacterium nucleatum promotes cancer through cellular proliferation and some strains of Escherichia coli and Bacteroides fragilis produce genotoxins.However,dysbiosis may also cause a proinflammatory state and the stimulation of a Th17 response with IL-17 and IL-22 secretion that have a pro-oncogenic activity,as demonstrated for Fusobacterium nucleatum.Microbiota has a crucial role in several stages of postoperative course;dysbiosis in fact seems related with surgical site infections and Enterococcus faecalis(and other collagenase-producers microbes)are suggested as a cause of anastomotic leak.Consequently,unbalanced presence of some species,together with altered immune response may also have a prognostic role.Microbiota has also a substantial role in effectiveness of chemotherapy,chemoresistance and in the related side effects.In other words,a complete knowledge of the fine pathological mechanisms of gut microbiota may provide a wide range of new diagnostic tools other than therapeutic targets in the light of tailored medicine. | Ilenia Bartolini Matteo Risaliti Maria Novella Ringressi Filippo Melli Giulia Nannini Amedeo Amedei Paolo Muiesan Antonio Taddei | 2020 | World Journal of Gastroenterology2020，26，20： | 6 |
| 2 | Esophageal surgery in minimally invasive era显示文摘The widespread popularity of new surgical technologies such as laparoscopy, thoracoscopy and robotics has led many surgeons to treat esophageal diseases with these methods. The expected benefits of minimally invasivesurgery(MIS) mainly include reductions of postoperative complications, length of hospital stay, and pain and better cosmetic results. All of these benefits could potentially be of great interest when dealing with the esophagus due to the potentially severe complications that can occur after conventional surgery. Moreover, robotic platforms are expected to reduce many of the difficulties encountered during advanced laparoscopic and thoracoscopic procedures such as anastomotic reconstructions, accurate lymphadenectomies, and vascular sutures. Almost all esophageal diseases are approachable in a minimally invasive way, including diverticula, gastro-esophageal reflux disease, achalasia, perforations and cancer. Nevertheless, while the limits of MIS for benign esophageal diseases are mainly technical issues and costs, oncologic outcomes remain the cornerstone of any procedure to cure malignancies, for which the long-term results are critical. Furthermore, many of the minimally invasive esophageal operations should be compared to pharmacologic interventions and advanced pure endoscopic procedures; such a comparison requires a difficult literature analysis and leads to some confounding results of clinical trials. This review aims to examine the evidence for the use of MIS in both malignancies and more common benign disease of the esophagus, with a particular emphasis on future developments and ongoing areas of research. | lapo bencini luca moraldi ilenia bartolini andrea coratti | 2016 | World Journal of Gastrointestinal Surgery2016，8，1： | 5 |
| 3 | Aeromonas veronii biovar veronii and sepsis-infrequent complication of biliary drainage placement: A case report显示文摘BACKGROUND Aeromonas species are uncommon pathogens in biliary sepsis and cause substantial mortality in patients with impaired hepatobiliary function. Asia has the highest incidence of infection from Aeromonas,whereas cases in the west are rare.CASE SUMMARY We report the case of a 64-year-old woman with advanced pancreatic cancer and jaundice who manifested fever,abdominal pain,severe thrombocytopenia,anemia and kidney failure following the insertion of a percutaneous transhepatic biliary drainage. Blood culture results revealed the presence of Aeromonas veronii biovar veronii(A. veronii biovar veronii). After antibiotic therapy and transfusions,the life-threatening clinical conditions of the patient improved and she was discharged.CONCLUSION This was a rare case of infection,probably the first to be reported in West countries,caused by A. veronii biovar veronii following biliary drainage. A finding of Aeromonas must alert clinician to the possibility of severe sepsis. | Manlio Monti Arianna Torri Elena Amadori Alice Rossi Giulia Bartolini Chiara Casadei Giovanni Luca Frassineti | 2019 | World Journal of Clinical Cases2019，7，6： | 4 |
| 4 | Minimally invasive surgical approach to pancreatic malignancies显示文摘Pancreatic surgery for malignancy is recognized as challenging for the surgeons and risky for the patientsdue to consistent perioperative morbidity and mortality. Furthermore, the oncological long-term results are largely disappointing, even for those patients who experience an uneventfully hospital stay. Nevertheless, surgery still remains the cornerstone of a multidisciplinary treatment for pancreatic cancer. In order to maximize the benefits of surgery, the advent of both laparoscopy and robotics has led many surgeons to treat pancreatic cancers with these new methodologies. The reduction of postoperative complications, length of hospital stay and pain, together with a shorter interval between surgery and the beginning of adjuvant chemotherapy, represent the potential advantages over conventional surgery. Lastly, a better cosmetic result, although not crucial in any cancerous patient, could also play a role by improving overall well-being and patient self-perception. The laparoscopic approach to pancreatic surgery is, however, difficult in inexperienced hands and requires a dedicated training in both advanced laparoscopy and pancreatic surgery. The recent large diffusion of the da Vinci® robotic platform seems to facilitate many of the technical maneuvers, such as anastomotic biliary and pancreatic reconstructions, accurate lymphadenectomy, and vascular sutures. The two main pancreatic operations, distal pancreatectomy and pancreaticoduodenectomy, are approachable by a minimally invasive path, but more limited interventions such as enucleation are also feasible. Nevertheless, a word of caution should be taken into account when considering the increasing costs of these newest technologies because the main concerns regarding these are the maintenance of all oncological standards and the lack of long-term follow-up. The purpose of this review is to examine the evidence for the use of minimally invasive surgery in pancreatic cancer(and less aggressive tumors), with particular attention to the oncological results and widespread reproducibility of each technique. | Lapo Bencini Mario Annecchiarico Marco Farsi Ilenia Bartolini Vita Mirasolo Francesco Guerra Andrea Coratti | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 3 |
| 5 | Gut microbiota and immune system in liver cancer:Promising therapeutic implication from development to treatment显示文摘Liver cancer is a leading cause of death worldwide,and hepatocellular carcinoma(HCC)is the most frequent primary liver tumour,followed by cholangiocarcinoma.Notably,secondary tumours represent up to 90% of liver tumours.Chronic liver disease is a recognised risk factor for liver cancer development.Up to 90% of the patients with HCC and about 20% of those with cholangiocarcinoma have an underlying liver alteration.The gut microbiota-liver axis represents the bidirectional relationship between gut microbiota,its metabolites and the liver through the portal flow.The interplay between the immune system and gut microbiota is also well-known.Although primarily resulting from experiments in animal models and on HCC,growing evidence suggests a causal role for the gut microbiota in the development and progression of chronic liver pathologies and liver tumours.Despite the curative intent of“traditional”treatments,tumour recurrence remains high.Therefore,microbiota modulation is an appealing therapeutic target for liver cancer prevention and treatment.Furthermore,microbiota could represent a non-invasive biomarker for early liver cancer diagnosis.This review summarises the potential role of the microbiota and immune system in primary and secondary liver cancer development,focusing on the potential therapeutic implications. | Ilenia Bartolini Matteo Risaliti Rosaria Tucci Paolo Muiesan Maria Novella Ringressi Antonio Taddei Amedeo Amedei | 2021 | World Journal of Gastrointestinal Oncology2021，13，11： | 3 |
| 6 | Design and optimization of a semi-active suspension system for railway applications显示文摘The present work focused on the application of innovative damping technologies in order to improve rail-way vehicle performances in terms of dynamic stability and comfort.As a benchmark case-study,the secondary sus-pension stage was selected and different control techniques were investigated,such as skyhook,dynamic compensation,and sliding mode control.The ?nal aim was to investigate which control schemes are suitable for optimal exploitation of the non-linear behavior of the actuators.The performance improvement achieved by adoption of the semi-active dampers on a standard high-speed train was evaluated in terms of passenger comfort.Different control strategies have been investigated by comparing a simple SISO(single input single output) regulator based on the skyhook damper ap-proach with a centralized regulator.The centralized regulator allows for the estimation of a near optimal set of control forces that minimize car-body accelerations with respect to constraints imposed by limited performance of semi-active actuators.Simulation results show that best results is obtained using a mixed approach that considers the simultaneous applications of model based and feedback compensation control terms. | Benedetto ALLOTTA Luca PUGI Valentina COLLA Fabio BARTOLINI Francesco CANGIOLI | 2011 | Journal of Modern Transportation2011，19，4： | 2 |
| 7 | Robust speed and torque estimation in electrical drives by second -order sliding modes显示文摘 | Bartolini G Damiano A Gatto G | 2003 | IEEE Transactions on Control Systems Technology2003，11，1： | 2 |
| 8 | Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit显示文摘 | Robert W. Busby Alexander P. Bryant Wilmin P. Bartolini Etchell A. Cordero Gerhard Hannig Marco M. Kessler Shalina Mahajan-Miklos Christine M. Pierce Robert M. Solinga Li Jing Sun Jenny V. Tobin Caroline B. Kurtz Mark G. Currie | 2010 | European Journal of Pharmacology2010，，1： | 2 |
| 9 | Emerging drugs for non-small cell lung cancer显示文摘 | Cappuzzzo F Bartolini S Crino L | 2003 | Expert Opin Emerg Drugs2003，8，1： | 1 |
| 10 | Day-to-day monetary policy and the volatility of the Federal Funds interest rate显示文摘 | Bartolini L | 2002 | Journal of Money Credit and Banking2002，34，： | 1 |
| 11 | Analytical methods for the determination of folic acid in a nolvmeric micellar carrier显示文摘 | V Andrisano M Bartolini C Bertucci | 2003 | Journal of Pharmaceutical and Biomedical analystica2003，32，： | 1 |
| 12 | Properties of a combined adaptive/second-order sliding mode control algorithm for some classes of uncertain nonlinear systems显示文摘 | BARTOLINI G FERRARA A GIACOMINI L | 2000 | 1EEE Transactions on Automatic Control2000，45，7： | 1 |
| 13 | Efficient sort-based skyline evaluation显示文摘 | I Bartolini P Ciaccia M Patella | 2008 | ACM Transaction on Database Systems2008，33，4： | 1 |
| 14 | Improved wavelet-based watermarking through pixel-wise masking显示文摘 | Bami M Bartolini F Piva A | 2001 | IEEE Transactions on Image Processing2001，10，5： | 1 |
| 15 | Improved wavelet-based watermarking through pixel - wise masking显示文摘 | BARNI M BARTOLINI F | 2001 | IEEE Trans Image Processing2001，10，5： | 1 |
| 16 | Improved wavelet-based watermarking through pixel-wise masking显示文摘 | BARMI M BARTOLINI F PIVA A | 2001 | IEEE Trans Image Proc2001，10，5： | 1 |
| 17 | Watermark Embedding: Hiding a Signal within a Cover Image显示文摘 | Bami M Podilchuk C I Bartolini F | 2001 | IEEE Communications Magazine2001，39，8： | 1 |
| 18 | Persistent impairment of gait performances and working memory after bilateral common carotid artery occlusion in the adult Wistar rat显示文摘 | Sarti C Pantoni L Bartolini L | 2002 | Behav Brain Res2002，136，1： | 1 |
| 19 | On Multi-input Chattering-free Second-order Sliding Mode Control 显示文摘 | Bartolini G Ferrara A Usai E | 2000 | IEEE Trans on Automatic Control (S0018-9286)2000，45，6： | 1 |
| 20 | Linaclotide is a potent and selective gnanylate cyclase C agonist that elicitsphannacolog- ical effects locally in the gastrointestinal tract显示文摘 | Bryant AP Busby RW Bartolini WP | 2010 | Life Sci2010，86，1920： | 1 |
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