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| 1 | Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development显示文摘Chronic obstructive pulmonary disease(COPD) significantly increases the risk of developing cancer. Biomarker studies frequently follow a case-control set-up in which patients diagnosed with a disease are compared to controls. Longitudinal cohort studies such as the COPD-centered German COPD and SYstemic consequences-COmorbidities NETwork(COSYCONET) study provide the patient and biomaterial base for discovering predictive molecular markers. We asked whether microRNA(miRNA) profiles in blood collected from COPD patients prior to a tumor diagnosis could support an early diagnosis of tumor development independent of the tumor type. From 2741 participants of COSYCONET diagnosed with COPD, we selected 534 individuals including 33 patients who developed cancer during the follow-up period of 54 months and 501 patients who did not develop cancer, but had similar age, gender and smoking history. Genome-wide miRNA profiles were generated and evaluated using machine learning techniques. For patients developing cancer we identified nine miRNAs with significantly decreased abundance(two-tailed unpaired t-test adjusted for multiple testing P < 0.05), including members of the miR-320 family. The identified mi RNAs regulate different cancer-related pathways including the MAPK pathway(P = 2.3 x 10^(-5)). We also observed the impact of confounding factors on the generated miRNA profiles, underlining the value of our matched analysis. For selected miRNAs, qRT-PCR analysis was applied to validate the results. In conclusion, we identified several miRNAs in blood of COPD patients, which could serve as candidates for biomarkers to help identify COPD patients at risk of developing cancer. | Andreas Keller Tobias Fehlmann Nicole Ludwig Mustafa Kahraman Thomas Laufer Christina Backes Claus Vogelmeier Caroline Diener Frank Biertz Christian Herr Rudolf A. Jorres Hans-Peter Lenhof Eckart Meese Robert Bals | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 9 |
| 2 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 3 | The novel resveratrol derivative 3,5-diethoxy-3',4'- dihydroxy-trans-stilbene induces mitochondrial ROS-mediated ER stress and cell death in human hepatoma cells in vitro显示文摘 | Jae-woo PARK Woo-gyun CHOI Phil-jun LEE Su-wol CHUNG Byung-sam KIM Hun-taeg CHUNG Sungchan CliO Jong-heon KIM Byoung-heon KANG Hyoungsu KIM Hong-pyo KIM Sung-hoon BACK | 2017 | Acta Pharmacologica Sinica2017，38，11： | 6 |
| 4 | The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy显示文摘The chemokine receptor CCR7 and its ligands CCL19 and CCL21 guide the homing and positioning of dendritic and T cells in lymphoid organs,thereby contributing to several aspects of adaptive immunity and immune tolerance.In the present study,we investigated the role of CCR7 in the pathogenesis of collagen-induced arthritis(CIA).By using a novel anti-human CCR7 antibody and humanized CCR7 mice,we evaluated CCR7 as a target in this autoimmune model of rheumatoid arthritis(RA).Ccr7-deficient mice were completely resistant to CIA and presented severely impaired antibody responses to collagen II(CII).Selective CCR7 expression on dendritic cells restored arthritis severity and anti-CII antibody titers.Prophylactic and therapeutic treatment of humanized CCR7 mice with anti-human CCR7 mAb 8H3-16A12 led to complete resistance to CIA and halted CIA progression,respectively.Our data demonstrate that CCR7 signaling is essential for the induction of CIA and identify CCR7 as a potential therapeutic target in RA. | Georgios L.Moschovakis Anja Bubke Michaela Friedrichsen Jasmin Ristenpart Jaap Willem Back Christine S.Falk Elisabeth Kremmer Reinhold Forster | 2019 | Cellular & Molecular Immunology2019，16，10： | 3 |
| 5 | Robotic Intra-Operative Ultrasound:Virtual Environments and Parallel Systems显示文摘Robotic intra-operative ultrasound has the potential to improve the conventional practice of diagnosis and procedure guidance that are currently performed manually.Working towards automatic or semi-automatic ultrasound,being able to define ultrasound views and the corresponding probe poses via intelligent approaches become crucial.Based on the concept of parallel system which incorporates the ingredients of artificial systems,computational experiments,and parallel execution,this paper utilized a recent developed robotic trans-esophageal ultrasound system as the study object to explore the method for developing the corresponding virtual environments and present the potential applications of such systems.The proposed virtual system includes the use of 3 D slicer as the main workspace and graphic user interface(GUI),Matlab engine to provide robotic control algorithms and customized functions,and PLUS(Public software Library for Ultra Sound imaging research)toolkit to generate simulated ultrasound images.Detailed implementation methods were presented and the proposed features of the system were explained.Based on this virtual system,example uses and case studies were presented to demonstrate its capabilities when used together with the physical TEE robot.This includes standard view definition and customized view optimization for pre-planning and navigation,as well as robotic control algorithm evaluations to facilitate real-time automatic probe pose adjustments.To conclude,the proposed virtual system would be a powerful tool to facilitate the further developments and clinical uses of the robotic intra-operative ultrasound systems. | Shuangyi Wang James Housden Tianxiang Bai Hongbin Liu Junghwan Back Davinder Singh Kawal Rhode Zeng-Guang Hou Fei-Yue Wang | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，5： | 3 |
| 6 | 有为腹的 CT 的非线性的适应过滤器的申请的放射剂量减小显示文摘 AIM:To evaluate the effect of non-linear adaptive filters (NLAF) on abdominal computed tomography (CT) images acquired at different radiation dose levels.METHODS:Nineteen patients (mean age 61.6 ± 7.9 years,M:F=8:11) gave informed consent for an Institutional Review Board approved prospective study involving acquisition of 4 additional image series (200,150,100,50 mAs and 120 kVp) on a 64 slice multidetector row CT scanner over an identical 10 cm length in the abdomen.The CT images acquired at 150,100 and 50 mAs were processed with the NLAF.Two radiologists reviewed unprocessed and processed images for image quality in a blinded randomized manner.CT dose index volume,dose length product,patient weight,transverse diameters,objective noise and CT numbers wererecorded.Data were analyzed using Analysis of Variance and Wilcoxon signed rank test.RESULTS:Of the 31 lesions detected in abdominal CT images,28 lesions were less than 1 cm in size.Subjective image noise was graded as unacceptable in unprocessed images at 50 and 100 mAs,and in NLAF processed images at 50 mAs only.In NLAF processed images,objective image noise was decreased by 21% (14.4 ± 4/18.2 ± 4.9) at 150 mAs,28.3% (15.7 ± 5.6/21.9 ± 4) at 100 mAs and by 39.4% (18.8 ± 9/30.4 ± 9.2) at 50 mAs compared to unprocessed images acquired at respective radiation dose levels.At 100 mAs the visibility of smaller structures improved from suboptimal in unprocessed images to excellent in NLAF processed images,whereas diagnostic confidence was respectively improved from probably confident to fully confident.CONCLUSION:NLAF lowers image noise,improves the visibility of small structures and maintains lesion conspicuity at down to 100 mAs for abdominal CT. | Sarabjeet Singh Mannudeep K Kalra Mi Kim Sung Anni Back Michael A Blake | 2012 | World Journal of Radiology2012，4，1： | 3 |
| 7 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 8 | Application of powdered activated carbon coating to fabrics in a hybrid filter to enhance mercury removal显示文摘Elemental mercury(Hg0) is predominant constituent of flue gas emitted from coal-fired power plants. Adsorption has been considered the best available technology for removal of Hg0 from flue gas. However, adsorbent injection increases the amount of ash generated. In the present study, powdered activated carbon(PAC) was coated on polytetrafluoroethylene/glass fiber filters to increase Hg0 removal while concurrently reducing the amount of ash generated. The optimal PAC coating rate was determined in laboratory experiments to ensure better Hg0 removal with low pressure drop. When PAC of particle size less than 45 μm was used, and the areal density was 50 g/m2, the pressure drop remained under 30 Pa while the Hg0 removal efficiency increased to 15.8% from4.3%. The Hg0 removal efficiency also increased with decrease in filtration velocity. The optimal PAC coating rate was applied on a hybrid filter(HF), which was combined with a bag filter and an electrostatic precipitator in a single chamber. Originally designed to remove fine particulates matter, it was retrofitted to the flue gas control device for simultaneous Hg0 removal. By employing the PAC coating, the Hg removal efficiency of the HF increased to 79.79% from 66.35%. Also, a temporary reduction in Hg removal was seen but this was resolved following a cleaning cycle in which the dust layer was removed. | Jin-Ho Sung Seung-Ki Back Eun-Song Lee Ha-Na Jang Yong-Chil Seo Youn-Suk Kang Myong-Hwa Lee | 2019 | Journal of Environmental Sciences2019，31，6： | 2 |
| 9 | Multivariate miRNA signatures as biomarkers for non-ischaemic systolic heart failure显示文摘 | Britta Vogel Andreas Keller Karen S. Frese Petra Leidinger Farbod Sedaghat-Hamedani Elham Kayvanpour Wanda Kloos Christina Backe Ann Thanaraj Thomas Brefort Markus Beier Stefan Hardt Eckart Meese Hugo A. Katus Benjamin Meder | 2013 | European Heart Journal2013，，： | 2 |
| 10 | Auctions of divisible goods with endogenous supply显示文摘 | Kerry Back Jaime F. Zender | 2001 | Economics Letters2001，，1： | 2 |
| 11 | 正确处理重症监护中出现的医疗纠纷——有人谓之“痴心妄想”显示文摘医生常常认为。医患纠纷令人厌烦。还会带来伤害。但是。如果处理得好。医患纠纷也可有所收获。一旦双方把话说明,治疗决策就会更加明确。患者家属、患者本人及临床医生就会感到更加满意。B夫人84岁,处于老年痴呆晚期,先前曾声明不接受人为补液和营养支持。我们对她的经历进行了回顾分析。在患病过程中,其家属与医生就治疗时短期采用管饲和静脉补液产生了分歧。本文描述了B夫人的医生与其家属间产生的纠纷。介绍了重症监护中常见的纠纷类型(患者家属与治疗小组之间的纠纷、治疗小组成员之间的纠纷)。我们汲取了商业理论、心理学理论和调解理论。总结出一些有用的沟通手段和常见的误区。医生可采用我们概括的方法逐步解决医疗纠纷。也可运用尝试性治疗这一策略消除重症监护中产生的纠纷。 | Anthony L. Back Robert M. Arnold 欧阳泰山(译) 欧阳烨(校) | 2006 | 美国医学会杂志(中文版)2006，25，6： | 2 |
| 12 | The characteristics of compensation on temperature of ultrasonic motor with robot actuator by fuzzy controller显示文摘 | In - su Hea- Am Park Huyng -lae Back | 1996 | Proceedings of the IEEE International Symposium on Industrial Electronics1996，1，： | 2 |
| 13 | Functional and Anatomical Diagnosis of Coronary Artery Stenoses显示文摘 | Abhijit Sinha Roy Martin R. Back Saeb F. Khoury Eric W. Schneeberger Lloyd H. Back Vijaya V. Velury Ronald W. Millard Rupak K. Banerjee | 2008 | Journal of Surgical Research2008，，： | 2 |
| 14 | Machine Learning to Detect Alzheimer’s Disease from Circulating Non-coding RNAs显示文摘Blood-borne small non-coding(snc RNAs)are among the prominent candidates for blood-based diagnostic tests.Often,high-throughput approaches are applied to discover biomarker signatures.These have to be validated in larger cohorts and evaluated by adequate statistical learning approaches.Previously,we published high-throughput sequencing based microRNA(miRNA)signatures in Alzheimer’s disease(AD)patients in the United States(US)and Germany.Here,we determined abundance levels of 21 known circulating miRNAs in 465 individuals encompassing AD patients and controls by RT-qPCR.We computed models to assess the relation between miRNA expression and phenotypes,gender,age,or disease severity(Mini-Mental State Examination;MMSE).Of the 21 miRNAs,expression levels of 20 miRNAs were consistently de-regulated in the US and German cohorts.18 miRNAs were significantly correlated with neurodegeneration(Benjamini-Hochberg adjusted P<0.05)with highest significance for miR-532-5 p(BenjaminiHochberg adjusted P=4.8×10^-30).Machine learning models reached an area under the curve(AUC)value of 87.6%in differentiating AD patients from controls.Further,ten miRNAs were significantly correlated with MMSE,in particular miR-26a/26b-5p(adjusted P=0.0002).Interestingly,the miRNAs with lower abundance in AD were enriched in monocytes and T-helper cells,while those up-regulated in AD were enriched in serum,exosomes,cytotoxic t-cells,and B-cells.Our study represents the next important step in translational research for a miRNA-based AD test. | Nicole Ludwig Tobias Fehlmann Fabian Kern Manfred Gogol Walter Maetzler Stephanie Deutscher Simone Gurlit Claudia Schulte Anna-Katharina von Thaler Christian Deuschle Florian Metzger Daniela Berg Ulrike Suenkel Verena Keller Christina Backes Hans-Peter Lenhof Eckart Meese Andreas Keller | 2019 | Genomics, Proteomics & Bioinformatics2019，17，4： | 2 |
| 15 | The relative importance of graft surveillance and warfarin therapy in infrainguinal prosthetic bypass failure显示文摘 | Robert Scott Brumberg Martin R. Back Paul A. Armstrong David Cuthbertson Murray L. Shames Brad L. Johnson Dennis F. Bandyk | 2007 | Journal of Vascular Surgery2007，，： | 2 |
| 16 | BDNF blocks caspase-3 activation in neonatal hypoxia-ischemia显示文摘 | Han BH DCosta A Back SA | 2000 | Neurobiol Dis2000，7，1： | 1 |
| 17 | Perinatal white mailer injury : the changing spectrum of pathology and emerging insights into pathogenetic mechanisms 显示文摘 | Back SA | 2006 | Ment Retard Dev Disabil Res Rev2006，12，2： | 1 |
| 18 | Density-functional thermochemistry Ⅲ: The role of exact exchange显示文摘 | Backe A D | 1993 | J Chem Phys1993，98，7： | 1 |
| 19 | On the fundamental theorem of asset pricing with an infinite state space显示文摘 | Pliska | 1991 | J Math Ecom1991，20，： | 1 |
| 20 | Cellular markers of systemic inflammation and immune suppression in patients with organ failure due to severe acute pancreatitis 显示文摘 | Kylanpaa A Back ML Takala A | 2001 | Scand J Gastroenterol2001，36，10： | 1 |
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