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| 1 | Practical strategies for modulating foam cell formation and behavior显示文摘Although high density lipoprotein(HDL)-mediated reverse cholesterol transport is crucial to the prevention and reversal of atheroma, a recent meta-analysis makes evident that current pharmaceutical strategies for modulating HDL cholesterol levels lower cardiovascular risk only to the extent that they concurrently decrease low density lipoprotein(LDL) cholesterol. This corresponds well with findings of a recent Mendelian randomization analysis, in which genetic polymorphisms associated with HDL cholesterol but no other known cardiovascular risk factors failed to predict risk for myocardial infarction. Although it is still seems appropriate to search for therapies that could improve the efficiency with which HDL particles induce reverse cholesterol transport, targeting HDL cholesterol levels per se with current measures appears to be futile. Itmay therefore be more promising to promote reverse cholesterol transport with agents that directly target foam cells. Macrophage expression of the cholesterol transport proteins adenosine triphosphate binding cassette transporter A1, adenosine triphosphate binding cassette transporter G1, and scavenger receptor class B member 1 is transcriptionally up-regulated by activated liver X receptors(LXR), whereas nuclear factor(NF)-kappa B antagonizes their expression. Taurine, which inhibits atherogenesis in rodent studies, has just been discovered to act as a weak agonist for LXRalpha. Conversely, it may be possible to oppose NF-kappa B activation in macrophages with a range of measures. Induction of heme oxygenase-1, which can be attained with phase 2 inducer phytochemicals such as lipoic acid and green tea catechins, promotes reverse cholesterol transport in macrophages and inhibits atherogenesis in rodents, likely due to, in large part, NF-kappa B antagonism. Inhibition of macrophage nicotinamide adenine dinucleotide phosphate(NADPH) oxidase activity with the spirulina-derived bilirubin-mimetic phycocyanobilin may also oppose NF-kappa B activation, and salicylic acid similarly should be useful for this purpose. The 5' adenosine monophosphate-activated protein kinase activator berberine promotes macrophage reverse cholesterol transport in cell culture; metformin probably shares this property. Many of these measures could also be expected to promote plaque stability by suppressing foam cell production of inflammatory cytokines and matrix metalloproteinases, and to reduce intimal monocyte infiltration by anti-inflammatory effects on vascular endothelium. Direct targeting of foam cells with agents such as phase 2 inducers, spirulina, salicylate, taurine, and berberine or metformin, may hence have considerable potential for preventing and reversing atheroma, and for preventing the plaque rupture that triggers vascular thrombosis. | Elisabeth Uitz Babak Bahadori Mark F McCarty Mohammed H Moghadasian | 2014 | World Journal of Clinical Cases2014，2，10： | 6 |
| 2 | Vehicle routing problem with uncertain demands:An advanced particle swarm algorithm显示文摘 | Babak F M Rubén R Seyed J S | 2011 | Computers Industrial Engineering2011，62，1： | 1 |
| 3 | Synthesis of phosphorothioates usingthiophosphate salts显示文摘 | Babak K Fatemah F | 2006 | Beilstein Journal of Organic Chemis-try2006，2，4： | 1 |
| 4 | Application of ShuffledFrog-leaping Algorithm on Clustering显示文摘 | Babak A Mohammad F Maroosi A | 2009 | The International Journalof Advanced Manufacturing Technology2009，45，12： | 1 |
| 5 | Modal identification study of vincent thomas bridge using simulated wind-induced ambient vibration data 显示文摘 | He X F Babak M Conte J P | 2008 | Computer-Aided Civil and Infrastructure Engineering2008，23，： | 1 |
| 6 | Recovery of precious metals from ammoniaeal thiosulfate solutions by hybrid mesoporous silica: 1 - factors affecting gold adsorption 显示文摘 | Babak F Louis M | 2014 | Separa- tion and Purification Technology2014，127，： | 1 |
| 7 | Application of honey-bee mating optimization algorithmon clustering显示文摘 | Mohammad F Babak A | 2007 | Applied Mathematics and Computation2007，190，2： | 1 |
| 8 | On the power efficiency of sensory and ad hoc wireless networks 显示文摘 | Amir D Babak F H | 2006 | IEEE Transactions on Information Theory2006，52，7： | 1 |
| 9 | On the power efficiency of sensory and adhoc wireless networks 显示文摘 | Amir D Babak F H | 2006 | IEEE Transactions on Information Theory2006，52，7： | 1 |
| 10 | A nomogram to predict the probability of live birth after clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility显示文摘 | Babak Imani Marinus J.C Eijkemans Egbert R te Velde J.Dik F Habbema Bart C.J.M Fauser | 2002 | Fertility and Sterility2002，，1： | 1 |
| 11 | A strain rate dependent yield criterion for isotropic polymers: Low to high rates of loading 显示文摘 | Babak F Akhtar S K | 2010 | European Journal of Mechanics A/solids2010，29，2： | 1 |
| 12 | Prediction of acoustic noise in switched reluctance motor drives显示文摘 | Lin Chenjie Babak F | 2014 | IEEE Transactions on Energy on Energy Conversion2014，29，1： | 1 |
| 13 | Rapid detection of MDR-My-cobacterium tuberculosis using modified PCR-SSCP from clinicalSpecimens显示文摘 | AliIF Babak F Fazlollah MS | 2014 | Asian Pac J Trop Biomed2014，4，1： | 1 |
| 14 | The effect of salt on the performance and characteristics of a combined anaerobic-aerobic biological process for the treatment of synthetic wastewaters containing Reactive Black 5显示文摘 | Bahareh K Babak B Shahrzad F | | 0，，1： | 1 |
| 15 | Application of shuf-fled frog- leaping algorithm on clustering 显示文摘 | A Babak F Mohammad MAII | 2009 | The International Joumal of Advanced Manufacturing Technology2009，45，12： | 1 |
| 16 | 显示文摘 | Richard J C Babak F Paul K T L | 2004 | Chem Eng Sci2004，59，： | 1 |
| 17 | Numerical analysis of concrete block pavements and comparison of its settlement with asphalt concrete pavements using finite element method显示文摘 | GHOLAM A AFSHIN F BABAK P | 2014 | Engineering Journal2014，18，4： | 1 |
| 18 | Species abundance distribution and dynamics in two locally coupled communities 显示文摘 | BABAK P HE F | 2008 | Journal of Theoretical Biology2008，253，4： | 1 |
| 19 | Theory ofelectrostatic dispersion of polymer solutions in the pro-duction of microgel beads containing biocatalyst 显示文摘 | Poncelet D Babak V G Goosen M F A | 1999 | Ad-vances in Colloid and Interface Science1999，79，23： | 1 |
| 20 | Generalized proportional intensities models for repairable systems 显示文摘 | DAVID F P BABAKALLI M A | 2006 | Journal of Management Mathematics2006，17，2： | 1 |
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