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| 1 | Cirrhosis and its complications:Evidence based treatment显示文摘Cirrhosis results from progressive fibrosis and is the final outcome of all chronic liver disease.It is among the ten leading causes of death in United States.Cirrhosis can result in portal hypertension and/or hepatic dysfunction.Both of these either alone or in combination can lead to many complications,including ascites,varices,hepatic encephalopathy,hepatocellular carcinoma,hepatopulmonary syndrome,and coagulation disorders.Cirrhosis and its complications not only impair quality of life but also decrease survival.Managing patients with cirrhosis can be a challenge and requires an organized and systematic approach.Increasing physicians’knowledge about prevention and treatment of these potential complications is important to improve patient outcomes.A literature search of the published data was performed to provide a comprehensive review regarding the management of cirrhosis and its complications. | Salman Nusrat Muhammad S Khan Javid Fazili Mohammad F Madhoun | 2014 | World Journal of Gastroenterology2014，20，18： | 14 |
| 2 | Nat Med:靶向两分子或有助于彻底治愈白血病显示文摘科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。 | Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam | 2017 | 现代生物医学进展2017，17，17： | 4 |
| 3 | Differential reactivity of mouse monoclonal anti-HBs antibodies with recombinant mutant HBs antigens显示文摘AIM: To investigate the reactivity of a panel of 8 mouse anti-hepatitis B surface antigen (HBsAg) monoclonal antibodies (mAbs) using a collection of 9 recombinant HBsAg mutants with a variety of amino acid substitutions mostly located within the “a” region.METHODS: The entire HBs genes previously cloned into a mammalian expression vector were transiently transfected into COS7 cells. Two standard unmutated sequences of the ayw and adw subtypes served as controls. Secreted mutant proteins were collected and measured by three commercial diagnostic immunoassays to assess transfection efficiency. Reactivity of anti-HBs mAbs with mutated HBsAgs was determined by sandwich enzyme-linked immunosorbent assay (ELISA).RESULTS: Reactivity of anti-HBs mAbs with mutated HBsAgs revealed different patterns. While three mutants reacted strongly with all mAbs, two mutants reacted weakly with only two mAbs and the remaining proteins displayed variable degrees of reactivity towards different mAbs. Accordingly, four groups of mAbs with different but overlapping reactivity patterns could be envisaged. One group consisting of two mAbs (37C5-S7 and 35C6-S11) was found to recognize stable linear epitopes conserved in all mutants. Mutations outside the “a” determinant at positions 120 (P→S), 123(T→N) and 161(M→T) were found to affect reactivity of these mAbs.CONCLUSION: Our findings could have important implications for biophysical studies, vaccination strategies and immunotherapy of hepatitis B virus (HBV) mutants. | Azam Roohi Yaghoub Yazdani Jalal Khoshnoodi Seyed Mohammad Jazayeri William F Carman Mahmood Chamankhah Manley Rashedan Fazel Shokri | 2006 | World Journal of Gastroenterology2006，12，33： | 4 |
| 4 | Rare presentation of primary (AL) amyloidosis as gastrointestinal hemorrhage without systemic involvement显示文摘We are reporting a rare case of a patient with primary(AL) amyloidosis presenting with an acute non-varicealupper gastrointestinal hemorrhage in the absence ofother systemic involvement. The case report involves a58-year-old woman with significant cardiac history andhereditary blood disorder who came in complaining ofabdominal pain and coffee-ground emesis for two days.Computed tomography(CT) scan of the abdomen andpelvis with contrast revealed segmental wall thickeningof the proximal jejunum with hyperdense, heterog-enous luminal content. Similar findings were evident inthe left lower small bowel region, suspicious for smallbowel hematoma and the possibility of intraluminalclots. Esophagogastroduodenoscopy performed postresuscitation showed punctate, erythematous lesionsthroughout the stomach as well as regions of smallbowel mucosa that appeared scalloped, ulcerated, andhemorrhaged on contact. Despite initial treatment for immunostain-positive focal cytomegalovirus gastritis, follow-up esophagogastroduodenoscopy after two months continued to demonstrate friable and irregular duodenal mucosa hinting at a different underlying etiol-ogy. Pathology reports from analyses of biopsy samples highlighted infiltration and expansion of the lamina pro-pria and submucosa. Subsequent staining with congo red/crystal violet and appropriate subtyping established the diagnosis of AL(kappa)-type amyloidosis. The sig-nificance of this case lies in the fact that our patient did not have the typically seen diagnostic systemic involvements-namely of heart and kidneys-usually seen in primary(AL) amyloidosis patients. It was the persis-tent endoscopic findings and biopsy results which gave clues to the physicians regarding the possibility of an abnormal protein-deposition entity. | Mohammad F Ali Anik Patel Stephanie Muller David Friedel | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 2 |
| 5 | Performance analysis of bearing-only tracking algorithm 显示文摘 | DAVID V HUY S MOHAMMAD F | 2004 | Proceedings of SHE2004，3365，7： | 1 |
| 6 | Flow Properties of Biomass and Coal Blends 显示文摘 | Mohammad Zulfiqar Behdad Moghtaderi Terry F Wall | 2006 | Fuel Processing Technology2006，，87： | 1 |
| 7 | Emergy- based fuzzy optimization approach for water reuse in an eco-industrial park 显示文摘 | MOHAMMAD SADEGH TASKHIRI TAN R R CHIU A S F | 2011 | Resources Conservation and Recycling2011，55，： | 1 |
| 8 | Polar compounds distribution of sunflower oil as affected by unsaponifiable matters of bene hull oil (BHO) and tertiary-butylhydroquinone (TBHQ) during deep-frying显示文摘 | Reza F Mohammad H T | 2010 | Food Chemistry2010，122，： | 1 |
| 9 | Promoting effl~ct of noble metals addition on activity and resistance to ~'arbon deposition in oxidative steam reforming of methane over NiO-MgO s~lid solu- tion 显示文摘 | Mohammad N Ken-ichiro F Kimihito S | 2006 | Catal Commun2006，7，2： | 1 |
| 10 | Effeet of low temperature on the aacorbic acid content and quality characteristics of frozen strawberry显示文摘 | Mohammad Ali Sahari Mohsen Boostani F | 2004 | Food Chemistry2004，，86： | 1 |
| 11 | Thermal and catalytic decomposition behavior of PVC mixed plastic waste with petroleum residue显示文摘 | Mohammad F A Mohammad N S | 2005 | Analytical and Applied Pyrolysis2005，74，12： | 1 |
| 12 | Application of ShuffledFrog-leaping Algorithm on Clustering显示文摘 | Babak A Mohammad F Maroosi A | 2009 | The International Journalof Advanced Manufacturing Technology2009，45，12： | 1 |
| 13 | Magnetic nanomaterials for hyperther- mia-based therapy and controlled drug delivery显示文摘 | Kumar C S S R Mohammad F | 2011 | Advanced drug de- livery reviews2011，63，9： | 1 |
| 14 | Autoim- mune encephalitis:recent updates and emerging challenges 显示文摘 | Ramanathan S Mohammad SS Brilot F | 2014 | J Clin Neurosci2014，21，5： | 1 |
| 15 | Numerical optimization technique for design of wheel profiles 显示文摘 | Hamid J Behrooz F Mohammad A E Asghar N A | 2008 | Wear2008，264，1： | 1 |
| 16 | Magnetic nanoma- terials for hyperthermia-based therapy and con- trolled drug delivery 显示文摘 | Kumar C S S R Mohammad F | 2011 | Adv Drug Deliv Rew2011，63，9： | 1 |
| 17 | Kcnq1ot1antisense noncoding RNA mediates lineagespecific transcriptional silencing through chromatinlevel regulation显示文摘 | PANDEY R R MONDAL T MOHAMMAD F | 2008 | Mol Cell2008，32，： | 1 |
| 18 | High temperature characteristics of AIGaN/GaN modulation doped field-effect transistors 显示文摘 | AKTAS O FAN Z F MOHAMMAD S N | 1996 | Appl Phys Lett1996，69，25： | 1 |
| 19 | Nepehinol-a new triterpene from Nepeta hindostana显示文摘 | Ahmad V U Bano S Mohammad F V | 1985 | Planta Med1985，，6： | 1 |
| 20 | Potential role of the Slit/ Robo signal pathway in angiogenesis 显示文摘 | Masakazu F Mohammad G Oichi K | 2006 | Vasc Med2006，11，： | 1 |
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