|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cytokeratms and carcinoembryonic antigen in diagnosis,staging and prognosis of colorectal adenocarcinoma显示文摘AIM: To evaluate the serum levels of cytokeratins and carcinoembryonic antigen (CEA) in diagnosis, staging and prognosis of patients with colorectal adenocarcinoma.METHODS: The sample consisted of 169 patients. One hundred blood donors formed the control group. Radical surgery was performed on 120 patients, with an average follow-up duration of 22.3 mo. Relapses occurred in 23individuals after an average of 18.09 mo. CEA was assayed via the Delfia(R) method with a limit of 5 ng/mL. Cytokeratins were assayed via the LIA-mat(R) TPA-M Prolifigen(R) method with a limit of 72 U/L.RESULTS: In the diagnosis of patients with colorectal adenocarcinoma, CEA showed a sensitivity of 56%, a specificity of 95%, a positive predictive value of 94%, a negative predictive value of 50% and an accuracy of 76.8%.TPA-M had a sensitivity of 70%, a specificity of 96%, a positive predictive value of 97%, a negative predictive value of 66% and an accuracy of 93.6%. The elevation of one of the markers was shown to have a sensitivity of 76.9%, a specificity of 91%, a positive predictive value of 93.5%, a negative predictive value of 70% and an accuracy of 83.6%.There was no variation in the levels of the markers according to the degree of cell differentiation while there was an elevation in their concentrations in accordance with the increase in neoplastic dissemination. There was a statistically significant difference between the patients with stage Ⅳ lesions and those with stages Ⅰ, Ⅱ and Ⅲ tumors.With regard to CEA, the averagelevel was 14.2 ng/mL in patients with stage Ⅰ lesions, 8.5 ng/mL in patients with stage Ⅱ lesions, 8.0 ng/mL in patients with stage Ⅲ lesions and 87.7 ng/mL in patients with stage Ⅳ lesions. In relation to TPA-M, the levels were 153.1 U/L in patients with stage Ⅰtumors, 106.5 U/L in patients with stage Ⅱ tumors, 136.3 U/L in patients with stage Ⅲ tumors and 464.3 U/L in patients with stage Ⅳ tumors. There was a statistical difference in patients with a high CEA level in relation to a shorter survival(P<0.05). However, there was no correlation between patients with high TPA-M levels and prognostic indices of patients undergoing radical surgery.CONCLUSION: Cytokeratins demonstrate a greater sensitivity than CEA in the diagnosis of colorectal adenocarcinoma.There is an increase in the sensitivity of the markers with tumor dissemination. Cytokeratins cannot identify the worse prognosis in patients undergoing radical surgery.Cytokeratins constitute an advance in the direction of a perfect tumor marker in the treatment of patients with colorectal cancer. | Luís C.Fernandes Su B.Kim Delcio Matos | 2005 | World Journal of Gastroenterology2005，11，5： | 21 |
| 2 | Peripheral and mesenteric serum levels of CEA and cytokeratins,staging and histopathological variables in colorectal adenocarcinoma显示文摘瞄准:为了评估在外设和 mes 伤寒浆液之间存在的差别,与颜色在病人 carcinoembryonic 铺平抗原(CEA ) 和 cytokeratins 表面的腺癌。方法:有颜色的 138 个病人表面的腺癌在在 1993 年 12 月和 2000 年 3 月之间的医院 Sao Paulo (UNIFESP-EPM 的外科的肠胃病学的纪律) 经历了外科的人,回顾地被分析。CEA 和 cytokeratin (TPA-M ) 之间的差别在外部血(P) 并且在 mes 伤寒血(M) 的层次被学习。协会在外设和 mes 伤寒层次和阶段和组织病理学说的变量(细胞分化,宏观的外观,肿瘤尺寸和淋巴、静脉的侵略的存在的度) 之间被调查。结果:差别在标记层次的数字价值被观察:CEA (M)(39.10 mg/L +/- 121.19 mg/L ) 对 CEA (P)(38.5 mg/L +/- 122.55 mg/L ) , P <
0.05;TPA-M (M)(325.06 U/L +/- 527.29 U/L ) 对 TPA-M (P)(279.48 U/L +/- 455.81 U/L ) , P <
0.01。mes 伤寒 CEA 层次在更先进的肿瘤是更高的(P <
0.01 ) ,在生长损害(34.44 mg/L +/- 93.07 mg/L )(P <
0.01 ) 并且与静脉的侵略(48.41 mg/L +/- 129.86 mg/L )(P <
0.05 ) 。外部 CEA 与更先进的阶段是更高的(P <
0.01 ) 并且在有静脉的侵略的损害(53.23 mg/L +/- 158.57 mg/L )(P <
0.05 ) 。病人表明了有更多的 TPA-M 层次预付肿瘤的伤寒、外部的增加的 mes (P <
0.01 并且 P <
0.01 ) 并且在非溃烂的损害[530.45 U/L +/- 997.46 U/L (P <
0.05 ) 并且 457.95 U/L +/- 811.36 U/L (P <
0.01 )] 。结论:肿瘤标记 CEA 和 cytokeratins 的 mes 伤寒层次比在这些的外部层次渲染表面的腺癌病人高。这些生物学的肿瘤标记的高水平与癌的传播的一个先进状态被联系。 | Ivan Gregório Ivankovics Luis César Fernandes Sarhan Sydeney Saad Delcio Matos | 2008 | World Journal of Gastroenterology2008，14，43： | 4 |
| 3 | Value of carcinoembryonic antigen and cytokeratins for the detection of recurrent disease following curative resection of colorectal cancer显示文摘瞄准:与颜色在病人为周期性的疾病的察觉评估 carcinoembryonic 抗原(CEA ) 和 cytokeratins 的手术后的连续试金的功效在激进的外科以后的表面的腺癌。方法:在 1993 和 2000 之间,有颜色的 120 个病人表面的腺癌在外科的肠胃病学的部门经历了激进的外科, Sao Paulo-Escola Paulista de Medicina 的联邦大学, Sao Paulo,巴西。周期的手术后的评估被 assaying 标记在外部浆液,结肠镜检查和成像检查执行。CEA 的存在与 72 U/L 阀值用 LIA 地席 TPA-M Prolifigen 方法与 5 microg/L 阀值,和 cytokeratins 用 Delfia 方法被检测。结果:在第一手术后的年里,没有周期性的疾病的病人有 CEA 的正常层次( 1.5 +/- 0.9 microg/L )并且单音的同种细胞的织物多肽 antigen-M ( TPA-M , 64.4 +/- 47.8 U/L ),当有复发的病人有 CEA 的高水平时( 6.9 +/- 9.8 microg/L , P <
0.01 )并且 TPA-M ( 192.2 +/- 328.8 U/L , P <
0.05 )。在第二手术后的年期间,没有肿瘤复发的病人有 CEA 的正常层次( 2.0 +/- 1.8 microg/L )并且 TPA-M ( 50.8 +/- 38.4 U/L ),当有复发的病人有 CEA 的高水平时( 66.3 +/- 130.8 microg/L , P <
0.01 )并且 TPA-M ( 442.7 +/- 652.8 U/L , P <
0.05 )。吝啬的后续时间是 22.3 瞬间。在 23 种情况中有复发。没有完成激进的切除,五个手术被动。在肿瘤标记层次的上升先于复发的鉴定:在七的 CEA (30%) 和在十一个个人(48%) 的 TPA-M。结论:由 CEA 和 cytokeratins 的连续试金的集中的后续允许颜色的早察觉表面的瘤复发。 | Luís C Fernandes Su B Kim Sarhan S Saad Delcio Matos | 2006 | World Journal of Gastroenterology2006，12，24： | 3 |
| 4 | Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)显示文摘 | Ant?nio Talvane Torres Oliveira Céline Pinheiro Adhemar Longatto-Filho Maria Jose Brito Olga Martinho Delcio Matos André Lopes Carvalho Vinícius Lima Vazquez Thiago Buosi Silva Cristovam Scapulatempo Sarhan Sydney Saad Rui Manuel Reis Fátima Baltazar | 2012 | Journal of Bioenergetics and Biomembranes2012，，1： | 1 |
| 5 | Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)显示文摘 | Ant?nio Talvane Torres Oliveira Céline Pinheiro Adhemar Longatto-Filho Maria Jose Brito Olga Martinho Delcio Matos André Lopes Carvalho Vinícius Lima Vazquez Thiago Buosi Silva Cristovam Scapulatempo Sarhan Sydney Saad Rui Manuel Reis Fátima Baltazar | 2012 | Journal of Bioenergetics and Biomembranes2012，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员