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| 1 | Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors显示文摘从锥蜗牛(Conus ) 的毒液的充满半胱氨酸的肽指向许多不同离子隧道。conopeptides 的一个家庭,伪 - conotoxins,明确地指向在神经与肌的连接和中央神经系统两个都发现的烟碱的醋胆素受体(nAChRs ) 的不同 isoforms。这个家庭进一步基于在半胱氨酸残余之间的氨基酸的数字被划分成亚科。某些伪 - conotoxins 的优美子类型选择对涉及 neurotransmitter 版本的调整的本国的 nAChR isoforms 的描述关键, Parkinson 的疾病和 nociception 的 pathophysiology。伪 - conotoxins 的结构 / 功能描述与改进力量或子类型选择导致了类似物的发展。脊梁结构的环合和脂性的一半的增加导致了伪 - conotoxins 的改进稳定性和 bioavailability,因此为口头上地可得到的治疗学铺平道路。在发展史, exogenomics 和分子的建模诺言的最近的进展有为 nAChRs 的特定的子类型的改进选择的伪 - conotoxins 和类似物的一个甚至更大的数字的发现。 | Layla AZAM J Michael MCINTOSH | 2009 | Acta Pharmacologica Sinica2009,30,6: | 25 |
| 2 | Autoregressive neural networks with exogenous variables for indoor temperature prediction in buildings显示文摘Thermal models of buildings are helpful to forecast their energy use and to enhance the control of their mechanical systems.However,these models are building-specific and require a tedious,error-prone and time-consuming development effort relying on skilled building energy modelers.Compared to white-box and gray-box models,data-driven(black-box)models require less development time and a minimal amount of information about the building characteristics.In this paper,autoregressive neural network models are compared to gray-box and black-box linear models to simulate indoor temperatures.These models are trained,validated and compared to actual experimental data obtained for an existing commercial building in Montreal(QC,Canada)equipped with roof top units for air conditioning.Results show that neural networks mimic more accurately the thermal behavior of the building when limited information is available,compared to gray-box and black-box linear models.The gray-box model does not perform adequately due to its under-parameterized nature,while the linear models cannot capture non-linear phenomena such as radiative heat transfer and occupancy.Therefore,the neural network models outperform the alternative models in the presented application,reaching a coefficient of determination R2 up to 0.824 and a root mean square error down to 1.11℃,including the error propagation over time for a 1-week period with a 5-minute time-step.When considering a 50-hour time horizon,the best neural networks reach a much lower root mean square error of around 0.6℃,which is suitable for applications such as model predictive control. | Benoit Delcroix Jérôme Le Ny Michel Bernier Muhammad Azam Bingrui Qu Jean-Simon Venne | 2021 | Building Simulation2021,14,1: | 3 |
| 3 | Bacterioplankton secondary production estimates for coastal waters of British Columbia,and California显示文摘 | Fuhrman J A Azam F | 1980 | Appl Environ Microbial1980,39,6: | 1 |
| 4 | IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1 and IL-6 production through a caspase 1-dependent mechanism显示文摘 | Netea M G Azam T Ferwerda G Girardin S E Walsh M Park J S Abraham E Kim J M Yoon D Y Dinarello C A and Kim S H | | 0,,: | 1 |
| 5 | Thymidine incorporation as a measure of heterotrophic bacterioplankton production in marine surface waters:evaluation and field results显示文摘 | Fuhrman J Azam F | 1982 | Mar Bio1982,66,: | 1 |
| 6 | Migrants,remittances and the household in Africa:A review of evidence显示文摘 | Azam J P Gubert F | 2006 | Journal of African Economies2006,15,2: | 1 |
| 7 | Multivalued Fixed Point Theorems in Cone b-Metric Spaces显示文摘 | AZAM A MEHMOOD N AHMAD J | 2013 | Journal of Inequalities and Applications2013,2013,1: | 1 |
| 8 | The microbial loop显示文摘 | Pomeroy LR Williams P J Azam F | | 0,,: | 1 |
| 9 | The ecological role of water-column microbes in the sea显示文摘 | Azam F Fenche T Field J G | 1983 | Marine Ecology-Progress Series1983,10,3: | 1 |
| 10 | Data-driven modeling, fault diagnosis and optimal sensor selection for HVAC chillers 显示文摘 | Namburu S M Azam M S Luo J | 2007 | IEEE Transactions on Automation Science and Engineering2007,4,3: | 1 |
| 11 | The ecological role of water column microbes in the sea显示文摘 | Azam F Fenchel T Field J G | 1983 | Mar Ecol Prog Ser1983,10,: | 1 |
| 12 | esopha-geal variceal band ligation in the primary prophylaxis ofvariceal hemorrhage : a multicentre randomized controlled trial显示文摘 | SHAH HA AZAM Z RAUF J et aL Carvedilol vs | 2014 | J Hepatol2014,60,4: | 1 |
| 13 | The ecological role of water-coltmm microbes in the sea显示文摘 | Azam F Fenchel T Field J | 1983 | Marine Ecology Progress Series1983,10,3: | 1 |
| 14 | Brain ischemia and reperfusion activates the eukaryotic initiation factor 2 alpha kinase,PERK显示文摘 | Kumar R Azam S Sullivan J M | 2001 | J Neurochem2001,77,5: | 1 |
| 15 | The effect of slaughter method on thequality of rainbow(Salmo gairdneri) during storage on ice显示文摘 | Azam K Mackie I M Smith J | 1989 | J FoodScience and Technology1989,24,: | 1 |
| 16 | Numerical modeling of tailings thickening for improved mine waste management显示文摘 | AZAM S JEERAVIPOOLVARN S SCOTT J D | 2009 | Journal of Environmental Informatics2009,13,2: | 1 |
| 17 | Thymidine incorporation as a measure of heterotrophic bacterioplankton production in marine surface waters: evaluation and field results显示文摘 | Fuhrman J A Azam F | 1982 | Mar Biol1982,66,: | 1 |
| 18 | The ecological role of water-column microbes in the sea 显示文摘 | Azam F Fenchel T Field J G | 1983 | Mar Ecol Progr1983,10,: | 1 |
| 19 | Comparative analysis of flower volatiles from nine citrus at three blooming stages 显示文摘 | Azam M Song M Fan F J | 2013 | lnt J Mol Sci2013,14,22: | 1 |
| 20 | Baeterioplankton secondary produc-tion estimates for coastal waters of British, Columbia, Antarctica and California显示文摘 | FU H J A AZAM F | 1980 | Applied Environment Microbial1980,39,6: | 1 |