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| 1 | Nat Med:靶向两分子或有助于彻底治愈白血病显示文摘科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。 | Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam | 2017 | 现代生物医学进展2017，17，17： | 4 |
| 2 | Differential reactivity of mouse monoclonal anti-HBs antibodies with recombinant mutant HBs antigens显示文摘AIM: To investigate the reactivity of a panel of 8 mouse anti-hepatitis B surface antigen (HBsAg) monoclonal antibodies (mAbs) using a collection of 9 recombinant HBsAg mutants with a variety of amino acid substitutions mostly located within the “a” region.METHODS: The entire HBs genes previously cloned into a mammalian expression vector were transiently transfected into COS7 cells. Two standard unmutated sequences of the ayw and adw subtypes served as controls. Secreted mutant proteins were collected and measured by three commercial diagnostic immunoassays to assess transfection efficiency. Reactivity of anti-HBs mAbs with mutated HBsAgs was determined by sandwich enzyme-linked immunosorbent assay (ELISA).RESULTS: Reactivity of anti-HBs mAbs with mutated HBsAgs revealed different patterns. While three mutants reacted strongly with all mAbs, two mutants reacted weakly with only two mAbs and the remaining proteins displayed variable degrees of reactivity towards different mAbs. Accordingly, four groups of mAbs with different but overlapping reactivity patterns could be envisaged. One group consisting of two mAbs (37C5-S7 and 35C6-S11) was found to recognize stable linear epitopes conserved in all mutants. Mutations outside the “a” determinant at positions 120 (P→S), 123(T→N) and 161(M→T) were found to affect reactivity of these mAbs.CONCLUSION: Our findings could have important implications for biophysical studies, vaccination strategies and immunotherapy of hepatitis B virus (HBV) mutants. | Azam Roohi Yaghoub Yazdani Jalal Khoshnoodi Seyed Mohammad Jazayeri William F Carman Mahmood Chamankhah Manley Rashedan Fazel Shokri | 2006 | World Journal of Gastroenterology2006，12，33： | 4 |
| 3 | Bacterial transformation and transport of organic matter in the southern California Bight 显示文摘 | Azam F Smith D C Cartucci A F | 1992 | Prog Oceanogr1992，30，4： | 1 |
| 4 | Bacterioplankton secondary production estimates for coastal waters of British Columbia,and California显示文摘 | Fuhrman J A Azam F | 1980 | Appl Environ Microbial1980，39，6： | 1 |
| 5 | A complex of the IL-1 homo-logue IL-lF7b and IL-18-binding protein reduces IL-18 activity显示文摘 | Bufler P Azam T Gamboni-Robertson F Reznikov LL Ku-mar S Dinarello CA Kim SH | 2002 | Proc Natl Acad Sci USA2002，99，13： | 1 |
| 6 | The antitumor histone deacety-lase inhibitor suberoylanilide hydroxamic acid exhibits anti-in-flammatory properties via suppression of cytokines显示文摘 | Leoni F Zaliani A Bertolini G Porro G Pagani P Pozzi P Dona G Fossati G Sozzani S* Azam T Bufler P Fantuzzi G Goncharov I Kim SH Pomerantz BJ Reznikov LL SiegmundB Dinarello CA Mascagni P | 2002 | ProcNatl Acad Sci USA2002，99，： | 1 |
| 7 | A complex of the IL-1 homologue IL-1F7b duces IL-18 activity显示文摘 | Buffer P Azam T Gamboni Robertson F | | Proc0，，13： | 1 |
| 8 | Algicidal bacteria in the sea and theirimpact on algal blooms显示文摘 | MAYALI X AZAM F 2004 | 2004 | Journal Eukaryotic Microbiology2004，51，2： | 1 |
| 9 | Thymidine incorporation as a measure of heterotrophic bacterioplankton production in marine surface waters:evaluation and field results显示文摘 | Fuhrman J Azam F | 1982 | Mar Bio1982，66，： | 1 |
| 10 | Comparative Effect of Organic and Inorganic Nitrogen Sources Applied to a Flooded Soil on Rice Yield and Availability of N显示文摘 | AZAM F | 1990 | Plant and Soil1990，125，2： | 1 |
| 11 | Hepatitis B virus and hepatocarcino- genesis 显示文摘 | Azam F Koulaouzidis A | 2008 | Ann Hepatol2008，7，2： | 1 |
| 12 | Adjuvant chemotherapy should be used as the standard of care for resectable pancreatic cancer显示文摘 | Amptoulach S Kalaitzakis E Azam F | 2009 | Can Ther2009，7，1： | 1 |
| 13 | Genome size distributions indicate variability and similarities among marine viral assemblages from diverse environments显示文摘 | Steward GF Montiel JL Azam F | | 0，，： | 1 |
| 14 | Migrants,remittances and the household in Africa:A review of evidence显示文摘 | Azam J P Gubert F | 2006 | Journal of African Economies2006，15，2： | 1 |
| 15 | Microbial structuring of marine ecosystems 显示文摘 | Azam F Malfatti F | 2007 | Nature Reviews Microbiology2007，，10： | 1 |
| 16 | Biogeochemical significance of bacterial biomass in the ocean's euphotic zone显示文摘 | CHO B C AZAM F | 1990 | Mar Ecol Prog Ser1990，63，2： | 1 |
| 17 | Microbial control of oceanic carbon flux:The plot thickens显示文摘 | Azam F | 1998 | Science1998，，280： | 1 |
| 18 | Release, movement and recovery of 3,4-dimethylpyrazole phosphate (DMPP), ammonium and nitrate from stabilized nitrogen fertilizer granules in a silty clay soil under laboratory conditions显示文摘 | Azam F Benckiser G MUller C | 2001 | Biol Fertil Soils2001，34，2： | 1 |
| 19 | Protein content and protein synthesis rates of planktonic marine bacteria显示文摘 | Simon M Azam F | 1989 | Mar Ecol Prog Ser1989，51，： | 1 |
| 20 | Nitrification inhibition in soil and ecosystem functioning-An overview显示文摘 | AZAM F FAROOQ S | 2003 | Pakistan Journal of Biological Sciences2003，6，6： | 1 |
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