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| 1 | Effectiveness of exercise in hepatic fat mobilization in nonalcoholic fatty liver disease: Systematic review显示文摘AIM: To investigate the efficacy of exercise interventions on hepatic fat mobilization in non-alcoholic fatty liver disease(NAFLD) patients.METHODS: Ovid-Medline, Pub Med, EMBASE and Cochrane database were searched for randomized trials and prospective cohort studies in adults aged ≥ 18 which investigated the effects of at least 8 wk of exercise only or combination with diet on NAFLD from 2010 to 2016. The search terms used to identify articles, in which exercise was clearly described by type, duration, intensity and frequency were: 'NASH', 'NAFLD', 'nonalcoholic steatohepatitis', 'non-alcoholic fatty liver disease', 'fat', 'steatosis', 'diet', 'exercise', 'MR spectroscopy' and 'liver biopsy'. NAFLD diagnosis, as well as the outcome measures, was confirmed by either hydrogen-magnetic resonance spectroscopy(H-MRS) or biopsy. Trials that included dietary interventions along with exercise were accepted if they met all criteria. RESULTS: Eight studies met selection criteria(6 with exercise only, 2 with diet and exercise with a total of 433 adult participants). Training interventions ranged between 8 and 48 wk in duration with a prescribed exercise frequency of 3 to 7 d per week, at intensities between 45% and 75% of VO2 peak. The most commonly used imaging modality was H-MRS and one study utilized biopsy. The effect of intervention on fat mobilization was 30.2% in the exercise only group and 49.8% in diet and exercise group. There was no difference between aerobic and resistance exercise intervention, although only one study compared thetwo interventions. The beneficial effects of exercise on intrahepatic triglyceride(IHTG) were seen even in the absence of significant weight loss. Although combining an exercise program with dietary interventions augmented the reduction in IHTG, as well as improved measures of glucose control and/or insulin sensitivity, exercise only significantly decreased hepatic lipid contents.CONCLUSION: Prescribed exercise in subjects with NAFLD reduces IHTG independent of dietary intervention. Diet and exercise was more effective than exercise alone in reducing IHTG. | Pegah Golabi Cameron T Locklear Patrick Austin Sophie Afdhal Melinda Byrns Lynn Gerber Zobair M Younossi | 2016 | World Journal of Gastroenterology2016，22，27： | 30 |
| 2 | Anatomically realistic multiscale models of normal and abnormal gastrointestinal electrical activity显示文摘One of the major aims of the International Union of Physiological Sciences (IUPS) Physiome Project is to develop multiscale mathematical and computer models that can be used to help understand human health. We present here a small facet of this broad plan that applies to the gastrointestinal system. Specifically, we present an anatomically and physiologically based modelling framework that is capable of simulating normal and pathological electrical activity within the stomach and small intestine. The continuum models used within this framework have been created using anatomical information derived from common medical imaging modalities and data from the Visible Human Project. These models explicitly incorporate the various smooth muscle layers and networks of interstitial cells of Cajal (ICC) that are known to exist within the walls of the stomach and small bowel. Electrical activity within individual ICCs and smooth muscle cells is simulated using a previously published simplified representation of the cell level electrical activity. This simulated cell level activity is incorporated into a bidomain representation of the tissue, allowing electrical activity of the entire stomach or intestine to be simulated in the anatomically derived models. This electrical modelling framework successfully replicates many of the qualitative features of the slow wave activity within the stomach and intestine and has also been used to investigate activity associated with functional uncoupling of the stomach. | Leo K Cheng Rie Komuro Travis M Austin Martin L Buist Andrew J Pullan | 2007 | World Journal of Gastroenterology2007，13，9： | 3 |
| 3 | A rapid method for estimating log P for organic chemicals显示文摘 | Veith G D Austin N M and Morris R T | 1979 | Water Res1979，13，： | 3 |
| 4 | 对应用选择性环氧酶2抑制剂或传统非甾体类抗炎药物老年患者上消化道出血的观察研究显示文摘目的 对应用选择性环氧酶2(COX 2)抑制剂和非选择性的非甾体类抗炎药(NSAIDs)的老年患者上消化道出血的比率进行比较。 设计 观察性队列研究。 设置 利用来自加拿大安大略2000年4月17日~2001年3月31日的官方数据,以确认基于人群的、初次使用NSAID的队列患者。 对象 年龄≥66岁,开始服用非选择性NSAIDs(n=5391)、双氯芬酸(diclofenac)加米索前列醇(misoprostol)(n=5087)、罗非昔布(rofecoxib)(n=14 583)或塞来昔布(celecoxib)(n=18 908),以及随机选择的没有服用NSAIDs的对照组(n=100 000)。 衡量结局的主要指标 每个药物组因上消化道出血入院的比值比(经过调整潜在的混杂因子)。 结果 与对照组相比,多变量模型表明,在服用非选择性NSAIDs(调整比值比为4.0,95%,可信区间为2.3~6.9,)、双氯芬酸加米索前列醇(3.0,1.7~5.6)以及罗非昔布(1.9,1.3~2.8)时,上消化道出血的短期危险性是增加的,而塞来昔布并没有增加(1.0,0.7~1.6)。与塞来昔布相比,非选择性的NSAIDs(4.4,2.3~8.5)、双氯芬酸加 米索前列醇(3.2,1.6—6.5)以及罗非昔布(1.9,1.2~2.8)的上消化道出血危险性显著增加。与罗非昔布相比,非选择性NSAIDs的上消化道出血危险性显著增加(1.9,1.0~3.5)。 结论 选择性COX | Muhammad Mamdani Paula A Rochon David N Juurlink Alex Kopp Geoffrey M Anderson Gary Naglie Peter C Austin Andreas Laupacis 邓瑞雪 | 2003 | 英国医学杂志中文版2003，6，3： | 2 |
| 5 | Evolutionary relationships among the Braconidae (Hymenoptera: Ichneumonoidea)inferred from partial 16S rDNA gene sequences显示文摘 | DOWTON M AUSTIN A D ANTOLIN M F | 1998 | Insect Mol Bio1998，7，2： | 2 |
| 6 | Current status of gamma Ti aluminides for aerospace applications显示文摘 | AUSTIN C M | 1999 | Current Opinion in Solid State and Materials Science1999，4，： | 1 |
| 7 | Phosphorus losses in irrigation from fertilized pasture显示文摘 | Austin N R Prendergast J B Collins M D | 1996 | Journal of Environ- mental Quality1996，25，： | 1 |
| 8 | Genetic improvement in the yield of winter:afurther evaluation 显示文摘 | AUSTIN R B FORD M A MORGAN C L | 1989 | J Agric Sci1989，112，： | 1 |
| 9 | Complex for- mation and ion ieeonductivity of polyphosphazene solid elee- trolytes显示文摘 | Blonsky P M Shriver D F Austin P E | 1986 | Solid State Ionies1986，18，： | 1 |
| 10 | Pore scale definition and computation from tomography data 显示文摘 | DUPLry p M AUSTIN P DELANEy G W SCHWARZ M P | 2011 | Computer Physics Communications2011，182，10： | 1 |
| 11 | Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level:a meta-analy-sis of population-based prospective studies显示文摘 | Hokanson J E Austin M A | 1996 | J Card-iovasc Risk1996，3，： | 1 |
| 12 | Detection of lung cancer using weighted digital analysis of breath biomarkcrs显示文摘 | Phillips M Altorki N Austin JH | 2008 | Clin Chim Acta2008，393，2： | 1 |
| 13 | The potential contribution of vegetation ecology to biodiversity research 显示文摘 | Austin M P | 1999 | Ecography1999，22，5： | 1 |
| 14 | Emergence of potato blight 1843-1846显示文摘 | AUSTIN B P M | 1964 | Nature1964，203，： | 1 |
| 15 | Interactions between intelligence and personality: Results from two large samples 显示文摘 | AUSTIN E J HOFER C M DEARY I J | 2000 | Personality and Individual Differences2000，29，： | 1 |
| 16 | Arabidopsis map kinase 4 negatively regulates systemic acquired resistance显示文摘 | Petersen M Brodersen P Naested H Andreasson E Lindhart U Johansen B Nielsen H B Lacy M Austin M J Parker J E | | 0，，： | 1 |
| 17 | A quantitative Australian approach to medium and small scale surveys based on soil stratigraphy and environmental correlation 显示文摘 | MCKENZIE N J AUSTIN M P | 1993 | Geoderma1993，57，： | 1 |
| 18 | Spatial Prediction of Species Distribution:An Interface between Ecological Theory and Statisticalmodelling 显示文摘 | Austin M P | 2002 | Ecological Modelling2002，157，： | 1 |
| 19 | Increased DNA vaccine delivery and immunogenicity by electroporation in vivo显示文摘 | WIDERA G AUSTIN M RABUSSAY D | 2000 | J Immunol2000，164，9： | 1 |
| 20 | Coordination of cooperative advertising in a two-level supply chain when manufacturer offers discount 显示文摘 | Yue J Austin J Wang M Huang Z | 2006 | European Journal of Operational Research2006，168，1： | 1 |
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