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| 1 | 血管紧张素受体阻断剂预防男性人群痴呆发生风险研究:前瞻性队列分析(摘要)显示文摘目的探讨血管紧张素受体拮抗剂能否预防阿尔茨海默病和老年痴呆症,或同时减少两种疾病的进展。
设计前瞻性队列分析。
资料来源2002—2006年美国退伍军人数据库。 | Nien-Chen Li Austin Lee Rachel A Whitmer Miia Kivipelto Elizabeth Lawler Lewis E Kazis Benjamin Wolozin 夏曙(译) 于世英(校) | 2010 | 英国医学杂志中文版2010，13，2： | 5 |
| 2 | Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation显示文摘AIM: To study the genesis of neointima formation in pulmonary hypertension(PH), we investigated the role of caveolin-1 and related proteins. METHODS: Male Sprague Dawley rats were given monocrotaline(M, 40 mg/kg) or subjected to hypobaric hypoxia(H) to induce PH. Another group was given M and subjected to H to accelerate the disease process(M + H). Right ventricular systolic pressure, right ventricular hypertrophy, lung histology for medial hypertrophy and the presence of neointimal lesions were examined at 2 and 4 wk. The expression of caveolin-1 and its regulatory protein peroxisome proliferator-activated receptor(PPAR) γ, caveolin-2, proliferative and antiapoptotic factors(PY-STAT3, p-Erk, Bcl-x L), endothelial nitric oxide synthase(e NOS) and heat shock protein(HSP) 90 in the lungs were analyzed, and the results from M + H group were compared with the controls, M and H groups. Double immunofluorescence technique was used to identify the localization of caveolin-1 in pulmonary arteries in rat lungs and in human PH lung tissue. RESULTS: In the M + H group, PH was more severe compared with M or H group. In the 4 wk M+H group, several arteries with reduced caveolin-1 expression in endothelial layer coupled with an increased expression in smooth muscle cells(SMC), exhibited neointimal lesions. Neointima was present only in the arteries exhibiting enhanced caveolin-1 expression in SMC. Lung tissue obtained from patients with PH also revealed neointimal lesions only in the arteries exhibiting endothelial caveolin-1 loss accompanied by an increased caveolin-1 expression in SMC. Reduction in e NOS and HSP90 expression was present in the M groups(2 and 4 wk), but not in the M + H groups. In both M groups and in the M + H group at 2 wk, endothelial caveolin-1 loss was accompanied by an increase in PPARγ expression. In the M + H group at 4 wk, increase in caveolin-1 expression was accompanied by a reduction in the PPARγ expression. In the H group, there was neither a loss of endothelial caveolin-1, eNOS or HSP 90, nor an increase in SMC caveolin-1 expression; or any alteration in PPARγ expression. Proliferative pathways were activated in all experimental groups. CONCLUSION: Enhanced caveolin-1 expression in SMC follows extensive endothelial caveolin-1 loss with subsequent neointima formation. Increased caveolin-1 expression in SMC, thus, may be a prelude to neointima formation. | Jing Huang John H Wolk Michael H Gewitz James E Loyd James West Eric D Austin Rajamma Mathew | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 3 | Wideband Statistics of Signal Levels and Doppler Spread on an Over-the-sea Transhorizon Link显示文摘 | NDZI D AUSTIN J VILAR E | 1997 | IEE Seminar Digests1997，，： | 1 |
| 4 | Continuous spectrophotometric assay for plant pectin methyl esterase显示文摘 | Hagerman A E Austin P J | 1986 | J Agric Food Chem1986，34，3： | 1 |
| 5 | Relationships between ability and personality: Three hypotheses tested 显示文摘 | AUSTIN E J DEARY I J Gibson G J | 1997 | Intelligence1997，25，： | 1 |
| 6 | Complex for- mation and ion ieeonductivity of polyphosphazene solid elee- trolytes显示文摘 | Blonsky P M Shriver D F Austin P E | 1986 | Solid State Ionies1986，18，： | 1 |
| 7 | Resuscitation- induced pulmonary apoptosis and intracellular adhesion mole-cule-1 expression in rats are attenuated by the use of ketone Ringer's solution 显示文摘 | ALAM H B AUSTIN B KOUSTOVA E | 2001 | Am Coil Surg2001，193，： | 1 |
| 8 | Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level:a meta-analy-sis of population-based prospective studies显示文摘 | Hokanson J E Austin M A | 1996 | J Card-iovasc Risk1996，3，： | 1 |
| 9 | Family history of diabetes and pancreatic cancer as risk factors for pancreatic cancer:the PACIFIC study显示文摘 | Austin MA Kuo E Van Den Eeden SK | 2013 | Cancer Epidemiol Biomarkers Prev2013，22，10： | 1 |
| 10 | A first step in the development of gene therapy for colorectal carcinoma:cloning sequencing and expression of escherichia coli cytosine deaminase显示文摘 | HUBER B E | 1993 | Mol Pharmacol1993，43，： | 1 |
| 11 | SimpleScalar:An Infrastructure for Computer System Modeling显示文摘 | Austin T Larson E Ernst D | 2002 | IEEE Computer2002，35，2： | 1 |
| 12 | Interactions between intelligence and personality: Results from two large samples 显示文摘 | AUSTIN E J HOFER C M DEARY I J | 2000 | Personality and Individual Differences2000，29，： | 1 |
| 13 | Arabidopsis map kinase 4 negatively regulates systemic acquired resistance显示文摘 | Petersen M Brodersen P Naested H Andreasson E Lindhart U Johansen B Nielsen H B Lacy M Austin M J Parker J E | | 0，，： | 1 |
| 14 | Precision measurements of the K^- and ∑^- masses 显示文摘 | GALL K P AUSTIN E MILLER J P | 1988 | Phys Rev Lett1988，60，3： | 1 |
| 15 | Interrelationship between cardiac hypertrophy, heart failure, and chronic kidney disease endoplasmic reticulum stress as a mediator of pathogenesis显示文摘 | DICKHOUTJ G CARLISLE R E AUSTIN R C | 2011 | Circ Res2011，108，5： | 1 |
| 16 | Inhibition of bacterial fish pathogens by Tetraselmis suecica显示文摘 | Austin B Baudet E Stobie M B C | 1992 | Journal offish Diseases1992，15，： | 1 |
| 17 | Rabbiteye blueberries: development, production, and marketing显示文摘 | Austin M E | 1994 | Agscienee Ine Aubumdale FL1994，，： | 1 |
| 18 | Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: Significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase显示文摘 | Huber B E Austin E A Richards C A | 1994 | Proc Natl Acad Sci USA1994，91，18： | 1 |
| 19 | Adaptive histogram equalization and its variations显示文摘 | PIZER S M AMBURN E P AUSTIN J D | 1987 | Computer Vision Graphics and Image Processing (CVGIP)1987，39，： | 1 |
| 20 | Polyphosp hazene solid electrolytes显示文摘 | Blonsky P M Shriver D F Austin P E | 1984 | J Am Chem Soc1984，1，06： | 1 |
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