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| 1 | Copy number variations are progressively associated with the pathogenesis of colorectal cancer in ulcerative colitis显示文摘AIM: To evaluate the association of known copy number variations(CNVs) in ulcerative colitis(UC) progressing to colorectal cancer.METHODS: Microsatellite instability analysis using the National Cancer Institute's panel of markers, and CNV association studies using Agilent 2 × 105 k arrays were done in tissue samples from four patient groups with UC: those at low risk(LR) or high risk of developing colorectal cancer, those with premalignant dysplastic lesions, and those with colitis-associated colorectal cancer(CAC). DNA from tissue samples of these groups were independently hybridized on arrays and analyzed. The data obtained were further subjected to downstream bioinformatics enrichment analysis to examine the correlation with CAC progression.RESULTS: Microarray analysis highlighted a progressive increase in the total number of CNVs [LR(n = 178) vs CAC(n = 958), 5.3-fold], gains and losses [LR(n = 37 and 141) vs CAC(n = 495 and 463), 13.4- and 3.3-fold, respectively], size [LR(964.2 kb) vs CAC(10540 kb), 10.9-fold] and the number of genes in such regions [LR(n = 119) vs CAC(n = 455), 3.8-fold]. Chromosomewise analysis of CNVs also showed an increase in the number of CNVs across each chromosome. There were 38 genes common to all four groups in the study; 13 of these were common to cancer genes from the Genetic Disease Association dataset. The gene set enrichment analysis and ontology analysis highlighted many cancerassociated genes. All the samples in the different groupswere microsatellite stable.CONCLUSION: Increasing numbers of CNVs are associated with the progression of UC to CAC, and warrant further detailed exploration. | Bhadravathi Marigowda Shivakumar Harish Rotti Thanvanthri Gururajan Vasudevan Aswath Balakrishnan Sanjiban Chakrabarty Ganesh Bhat Lakshmi Rao Cannanore Ganesh Pai Kapaettu Satyamoorthy | 2015 | World Journal of Gastroenterology2015，21，2： | 10 |
| 2 | Hysteresis behavior of t-stub connections with superelastic shape memory fasteners 显示文摘 | Abolmmali A Treadway J Aswath P | 2006 | Journal of Constructional Steel Research2006，62，： | 1 |
| 3 | Role of mineralizers on the hexacelsian to celsian transformation in the barium aluminosilicate (BAS) system显示文摘 | Aswath P B | 2003 | Mater Sci Eng A2003，352，： | 1 |
| 4 | Another story of MADS-box genes:their potential in plant biotechnology显示文摘 | Aswath C R Kim S H | 2005 | Plant Growth Regulation2005，46，： | 1 |
| 5 | Oxidation of ductile particle reinforced Ti-48Al composites显示文摘 | KEKARE S A TONEY J B ASWATH P B | 1995 | Metall Mater Trans1995，26，： | 1 |
| 6 | IbMADS4 regulates the vegetative shoot development in transgenic Chrysanthemum 显示文摘 | Aswath CR Mo S Y Kim S H | 2004 | Plant Science2004，166，： | 1 |
| 7 | Thermal Degradation Behavior of Zinc Dialkyldithiophos -phate in Presence of Catalyst and Detergents in Neutral oil 显示文摘 | M Z Huq X Chen P B Aswath | 2004 | Tribology Letters2004，19，2： | 1 |
| 8 | Isolation,char-acterization and evolution of NBS-LRR encoding disease-resistance gene analogsin eggplant against bacterial wilt显示文摘 | ANAND C R SUDARSHINI V S ASWATH C | 2015 | European Journal of Plant Pathology2015，143，3： | 1 |
| 9 | Synthesis and properties of in-situ Si3N4-reinforced BaO·Al2O3·SiO2 ceramic matrix composites显示文摘 | Quander S W Bandyopadhyay A Aswath P B | 1997 | J Mater Sci1997，32，： | 1 |
| 10 | High glucose modulates IL-6 mediated immune homeostasis through impeding neutrophil extracellular trap formation显示文摘 | Manjunath B. Joshi Apurva Lad Alevoor S. Bharath Prasad Aswath Balakrishnan Lingadakai Ramachandra Kapaettu Satyamoorthy | 2013 | FEBS Letters2013，，14： | 1 |
| 11 | Agrobacterium and biolistic transfo-rmation of onion using non-antibiotic selection marker phosphoma-nnose isomerase显示文摘 | Aswath C Mo S Kim D | 2006 | Plant Cell Rep2006，25，： | 1 |
| 12 | Over- expression of strawberry D-galacturenic acid reductase in potato leads to accumulation of vitamin C with enhanced abiotic stress tolerance 显示文摘 | Hemavathi Upadhyaya C P Young K E Akula N Kim H Heung J J Ohc O M Aswath C R Chun S C Kim D H Park S W | 2009 | Plant Science2009，177，6： | 1 |
| 13 | Kinetics of the hexacelsian to celsian transformation in barium aluminosilicates doped with CaO 显示文摘 | Lee K T Aswath P B | 2001 | Int J Inorg Mater2001，3，： | 1 |
| 14 | Nanotopography : Cellular Responses to Nanostructured Materials 显示文摘 | Kriparamanan R Aswath P Zhou A | 2006 | J Nanosci Nanotechnol2006，6，7： | 1 |
| 15 | Morphology, stru-cture and chemistry of extracted diesel soot: part II: X-ray absorption near edge structure (XANES) spectroscopy and high resolution trans- mission electron microscopy显示文摘 | Patel M Aswath P B | 2012 | Tribology International2012，52，： | 1 |
| 16 | Tribological behavior and nature of tribofilms generated from fluorinated ZDDP in comparison to ZDDP under extreme pressure conditions - Part 1 : structure and chemistry of tribofilms 显示文摘 | Mourhateh R Aswath P B | 2010 | Tribology International2010，44，： | 1 |
| 17 | TEM studies of anti - wear films/wear particles generated under boundai3, eonditions lubrication显示文摘 | Huq M Z Aswath P B Elsenbaumer R L | 2007 | Tribology International2007，40，： | 1 |
| 18 | IbMADS4 regulates the vegetative shoot development in transgenic Chrysanthemum(Dendranthema grandiflorum(Ramat)Kitamura)显示文摘 | Aswath CR Mo SY Kim SH | 2004 | Plant Science2004，166，： | 1 |
| 19 | The Weekend Effect in Information Releases : A Study of Earning and Dividend Announcements显示文摘 | Damodaran Aswath | 1989 | Review of Financial Studies1989，2，4： | 1 |
| 20 | Polymorphism analysis of six selenoprotein genes: support for a selective sweep at the glutathione peroxidase 1 locus (3p21) in Asian populations显示文摘 | Charles B Foster Kshama Aswath Stephen J Chanock | 2006 | BMC Genetics2006，7，： | 1 |
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