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| 1 | Sitagliptin,sitagliptin and metformin,or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats显示文摘Diabetic neuropathies are a family of nerve disorders caused by diabetes.Symptoms of the disease include nerve palsy,mononeuropathy,mononeuropathy multiplex,diabetic amyotrophy,painful polyneuropathy,autonomic neuropathy,and thoracoabdominal neuropathy.In this study,type 2 diabetes in rats was induced with nicotinamidestreptozotocin.Drug treatment was initiated on the d 15,with the combination regimen of metformin,pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin,amitriptyline and sitagliptin and led to significantly improved glycemic control,increased grip strength and paw jumping response on d 21,28 and 35(P < 0.001).Significant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21,28 and 35(P < 0.001).Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells,while administration of metformin and sitagliptin showed tissue regeneration and no body weight gain.In conclusion,treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain,but causes an increase in grip strength and pain sensitivity,exhibits neural protection,and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes. | Ashish Kumar Sharma Akash Sharma Rita Kumari Kunal Kishore Divya Sharma Bharthu Parthsarthi Srinivasan Ashok Sharma Santosh Kumar Singh Samir Gaur Vijay Singh Jatav Prashant Sharma Varnika Srivastava Sneha Joshi Megha Joshi Prashant Kumar Dhakad Davender Singh Kanawat Akanksha Mishra Anil Sharma Dharmendra Singh Ravinder Pal Singh Himmat Singh Chawda Rambir Singh Sachin Kumar Raikwar Muneem Kumar Kurmi Pankaj Khatri Ashutosh Agarwal Arshee Munajjam | 2012 | The Journal of Biomedical Research2012，26，3： | 2 |
| 2 | Significance of anterior commissure involvement in early glottic squamous cell carcinoma treated with trans‐oral CO2 laser microsurgery显示文摘 | Arsheed H. Hakeem Jagadish Tubachi Sultan A. Pradhan | 2013 | The Laryngoscope2013，，8： | 1 |
| 3 | Micro RNA biogenesis factor DRB 1 is a phosphorylation target of mitogen activated protein kinase MPK 3 in both rice and Arabidopsis显示文摘 | Badmi Raghuram Arsheed H. Sheikh Yashika Rustagi Alok K. Sinha | 2015 | FEBS J2015，，3： | 1 |
| 4 | Involvement of adenosine and standardization of aqueous extract of garlic(Allium sativum Linn.)on cardioprotective and cardiodepressant properties in ischemic preconditioning and myocardial ischemia-reperfusion induced cardiac injury显示文摘The present study investigated the effect of garlic(Allium sativum Linn.)aqueous extracts on ischemic preconditioning and ischemia-reperfusion induced cardiac injury,as well as adenosine involvement in ischemic preconditioning and garlic extract induced cardioprotection.A model of ischemia-reperfusion injury was established using Langendorff apparatus.Aqueous extract of garlic dose was standardized(0.5%,0.4%,0.3%,0.2%,0.1%,0.07%,0.05%,0.03%,0.01%),and the 0.05% dose was found to be the most effective.Higher doses(more than 0.05%)were highly toxic,causing arrhythmia and cardiodepression,whereas the lower doses were ineffective.Garlic exaggerated the cardioprotective effect of ischemic preconditioning.The cardioprotective effect of ischemic preconditioning and garlic cardioprotection was significantly attenuated by theophylline(1,000 μmol/L)and 8-SPT(10 mg/kg,i.p.)and expressed by increased myocardial infarct size,increased LDH level,and reduced nitrite and adenosine levels.These findings suggest that adenosine is involved in the pharmacological and molecular mechanism of garlic induced cardioprotection and mediated by the modulation of nitric oxide. | Ashish Kumar Sharma Arshee Munajjam Bhawna Vaishnav Richa Sharma Ashok Sharma Kunal Kishore Akash Sharma Divya Sharma Rita Kumari Ashish Tiwari Santosh Kumar Singh Samir Gaur Vijay Singh Jatav Barthu Parthi Srinivasan Shyam Sunder Agarwal | 2012 | The Journal of Biomedical Research2012，26，1： | 1 |
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