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| 1 | Arabidopsis Protein Phosphatase 2C ABI1 Interacts with Type I ACC Synthases and Is Involved in the Regulation of Ozone-Induced Ethylene Biosynthesis显示文摘它的生合成严格地是的在各种各样的生物过程并且因此的一个关键角色由 multiplemechanisms 调整了的乙烯戏。Posttranslational 规定,在控制乙烯生合成枢轴,经由特定的因素的复杂相互影响影响 1-aminocyclopropane1-carboxylate synthase (交流) 蛋白质稳定性。这里,我们证明 Arabidopsis thaliana 蛋白质磷酸酶打 2C, ABI1, abscisic 酸发信号的一个否定管理者,在氧化压力条件下面涉及 ethylenebiosynthesis 的规定。我们发现 ABI1 与 ACS6 和 dephosphorylates 交往它的 C-terminalfragment,压力应答的激活 mitogen 的蛋白质 kinase 的一个目标, MPK6。另外, ABI1 控制 MPK6 也 activitydirectly 并且由这个工具影响 ACS6 phosphorylation 水平。一致地与这,在 ABI1 猛烈紧张(abi1td ) 显著地更高的导致臭氧的乙烯 productionwas 比在野类型的植物。重要地,在 abi1td 异种的导致压力的乙烯生产的增加由一个更高的 ascorbate 氧化还原作用状态被补偿并且提高了抗氧化剂活动。总的来说, thisstudy 的结果提供 ABI1 由影响 ACS6 的活动限制乙烯合成的证据。ABI1 贡献 tostress 显型支撑它在在 abscisic 酸(骆驼毛的织物) 和表明 pathways.Key 词的乙烯之间的相互影响的角色: | Agnieszka Ludwikow Agata Ciesla Anna Kasprowicz-Malusk Filip Mitula Malgorzata Tajdel lukasz Gaigarnski Piotr A. Ziolkowski Piotr Kubiak Arleta Malecka Aneta Piechalak Marta Szabat Alicja Gorska Maciej Dabrowskia Izabela Ibragimow Jan Sadowski | 2014 | Molecular Plant2014，7，6： | 6 |
| 2 | Fatty acid changes help to better understand regression of nonalcoholic fatty liver disease显示文摘AIM: To investigate whether liver steatosis reduction due to a six-month dietary intervention results in significant changes in the concentrations of fatty acids.METHODS: A group of 35 Caucasian individuals diagnosed with different levels of steatosis were prospectively enrolled in the present study.Analysis of the fatty acid profiles was performed according to changes in liver steatosis(liver steatosis reduction by one or two degrees) after a six-month dietary intervention.The diet helped reduce body mass in obese and overweight patients,and stabilize both glycemia and dyslipidemia.Fatty acids were extracted according to the Folch method and analyzed by gas chromatography.RESULTS: This study showed significant changes in fatty acid profiles in patients who had reduced liver steatosis by one as well as two degrees.A reduction in liver steatosis by one degree caused a significant increase in the level of the n-3 family: eicosapentaenoic acid(P < 0.055),docosapentaenoic acid-C 22:5(P < 0.05) and docosahexaenoic acid(P < 0.05).A reduction in liver steatosis by two degrees caused a significant decrease in serum palmitoleic acid-C 16:1(P < 0.05).CONCLUSION: Liver steatosis reduction is associated with changes in fatty acid profiles,and these changes may reflect an alteration in fatty acid synthesis and metabolism.These findings may help better understand regression of nonalcoholic fatty liver disease. | Dominika Maciejewska Arleta Drozd Piotr Ossowski Karina Ryterska Dominika Jamio-Milc Marcin Banaszczak Joanna Raszeja-Wyszomirska Magorzata Kaczorowska Anna Sabinicz Ewa Stachowska | 2015 | World Journal of Gastroenterology2015，21，1： | 4 |
| 3 | 严重肢体缺血患者血浆中促血管生成潜力与血浆MMP-9、TIMP-1和TIMP-2水平升高的相关性研究(英文)显示文摘本研究通过比较间歇性跛行(IC)和严重肢体缺血(CLI)患者的血液参数,选择合适的临床和生化特指标,以评估促血管生成的潜力和抑制血管生成的作用.结果表明,通过刺激下肢动脉疾病(LEAD)病人血浆中的血管生成,内皮生长因子A(VEGF-A)浓度会显著增加,同时依赖于循环受体sVEGFR-1和sVEGFR-2的抑制也会显著减少.与IC病人相比,CLI病人具有较高的VEGF-A、金属蛋白酶9(MMP-9)、金属蛋白酶组织抑制因子1(TIMP-1)和TIMP-2浓度. | Radoslaw Wieczór Anna Maria Wieczór Arleta Kulwas Grzegorz Pulkowski Jacek Budzyński Danuta Rosc | 2019 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2019，20，8： | 3 |
| 4 | Rhizoremediation of Diesel-Contaminated Soil with Two Rapeseed Varieties and Petroleum degraders Reveals Different Responses of the Plant Defense Mechanisms显示文摘 | Joanna Wojtera-Kwiczor Weronika ?ukowska Weronika Graj Arleta Ma?ecka Aneta Piechalak Liliana Ciszewska ?ukasz Chrzanowski Piotr Lisiecki Izabela Komorowicz Danuta Bara?kiewicz Ingo Voss Renate Scheibe Barbara Tomaszewska | 2014 | International Journal of Phytoremediation (-)2014，，7： | 1 |
| 5 | Single nucleotide polymor- phisvas in the RET gene and their c~elations with Hirscksprung disease phenotype显示文摘 | Robert S Arleta L Dariusz P | 2006 | J Appl Genet2006，47，3： | 1 |
| 6 | Single nuclectide polymorohisms in the RET gene and their correlations with Hirsehsprung disease phenotype 显示文摘 | Robert S Arleta L | 2006 | J Appl Genet2006，47，3： | 1 |
| 7 | Assessment of ghrelin and leptin receptor levels in postmenopausal women who received oral or transdermal menopausal hormonal therapy显示文摘Objective:In postmenopausal women,an increased leptin concentration and reduced levels of ghrelin and adiponectin were observed.The aim of this study was to evaluate the concentrations of the active form of ghrelin,total ghrelin,leptin receptor,lipoprotein(a)(Lp(a)),and plasminogen activator inhibitor type 1(PAI-1) in postmenopausal women who received oral or transdermal menopausal hormonal therapy(MHT).Methods:The study involved 76 healthy women:46 women aged from 44 to 58 years who received oral(26) or transdermal(20) MHT;the control group consisted of 30 women aged from 44 to 54 years who did not receive MHT.The plasma concentrations of total ghrelin,the active form of ghrelin,Lp(a),and PAI-1:Ag were measured by enzyme-linked immunosorbent assay(ELISA).The concentration of the leptin receptor was measured by enzyme immunometric assay(EIA).Results:We observed a significantly higher concentration of total ghrelin and the active form of ghrelin in women who received transdermal MHT in comparison with those who took oral MHT.We also found a significantly lower concentration of total ghrelin in women who received oral MHT compared with the control group.A higher concentration of PAI-1:Ag was found in the group of women who took transdermal MHT in comparison with those who took oral MHT and with the control group.The differences were statistically significant.Additionally,we found a significant negative correlation between the concentrations of total ghrelin and PAI-1:Ag and a positive correlation between the concentrations of total ghrelin and leptin receptor in women who received transdermal MHT.Conclusions:The study showed that women who used transdermal MHT had higher levels of total ghrelin than women who took oral MHT.This indicates a beneficial effect of the transdermal route of MHT.However,transdermal therapy was associated with adverse effects with regard to the observed higher levels of PAI-1:Ag,which in turn,can lead to a reduction in fibrinolytic activity. | Barbara RUSZKOWSKA Alina SOKUP Arleta KULWAS Maciej W.SOCHA Krzysztof GóRALCZYK Barbara GóRALCZYK Danuta ROS | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，1： | 0 |
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