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| 1 | 自身荧光内镜在早期喉癌及其癌前病变诊断中的应用显示文摘目的研究用自身荧光内镜在早期喉癌和癌前病变诊断中的应用价值。方法75例疑有早期喉癌及癌前病变的患者在显微喉镜下暴露喉腔,由短弧氙灯提供的过滤蓝光(波长380~460nm)激发检查部位的自身荧光,通过高清晰度摄像系统获取自身荧光图像并加以分析、诊断,图像储存并与组织病理学结果做比较。结果正常喉黏膜和轻度上皮非典型性增生显示典型的亮绿色荧光信号,中、高度上皮非典型性增生,原位癌和浸润癌呈现绿色荧光的减少、消失;自身荧光内镜可把高度非典型性增生和癌前病变与低度非典型性增生和炎性病变区别开来,敏感度可达97.8%,特异性为86.7%。假阴性结果(1例)是由重度的上皮过度角化所致;黏膜的炎症充血和瘢痕易于产生假阳性结果(4例)。结论自身荧光内镜图像技术是无创性诊断喉癌及其癌前病变的辅助性方法,操作简单,敏感度高,但存在一定的假阳性率。 | 李勇 Christoph Arens Hiltrud Glanz | 2005 | 中华耳鼻咽喉头颈外科杂志2005，40，9： | 9 |
| 2 | 高频超声内窥镜在喉疾病诊断中的应用研究显示文摘目的 研究高频超声内窥镜技术在喉病变 ,特别是喉癌诊断中的应用。方法 用可屈的小内径 (8~ 10F)高频 (10~ 2 0MHz)内窥镜式超声探头 ,对 45例患者行喉腔内无创伤检查。在探头频率 10MHz最大测及 3cm ,探头频率 2 0MHz最大测及 1.5cm ,超声图像上能准确测量出肿瘤垂直直径大小及位置。结果 其中检查出 3 2例喉癌 ,与周围组织相比 ,呈现出典型的反射矩阵波。在显微喉镜检查中 ,借助高频超声可扫查到T1声带癌 (13例 )、最小瘤体直径约 3mm的浸润癌。但 13例中有 6例探测不到肿瘤(假阴性 ) ,假阳性结果尚未发现。T2 ~T3 喉癌 (12例 )较易诊断 ,在声门上区和声门下区肿瘤较周围组织显示低回声区 ;T4 肿瘤 (7例 )侵犯甲状软骨 ,在超声图像肿瘤的低回声区与甲状软骨内膜的高回声区有明显的反差。另外测及喉良性病变 13例。结论 运用内窥镜式高频超声可在显微镜检查中对喉病变 ,特别是喉肿瘤的大小及相应浸润范围 ,作出更为准确的诊断 。 | 李勇 王惠忠 Arens C Glanz H 栾信庸 潘信良 许凤雷 | 2003 | 中华超声影像学杂志2003，12，12： | 6 |
| 3 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 4 | 接触性内镜在早期喉癌及其癌前病变诊断中的应用显示文摘目的探索接触性内镜对早期喉癌及其癌前病变行微创病理学诊断的可行性。方法86例喉病变患者,在显微支撑喉镜下,于喉内病变处黏膜涂1%美蓝染色,将60×和150×接触性内镜置于黏膜表面,观察其病理变化,并与活检结果比较。结果接触性内镜的电子图像可较清晰显示表面黏膜不同病变细胞及核的大小、形状、排列、胞浆比、致密度和着色情况,有无中空细胞、核角蛋白,黏膜下微血管的排列情况。病理改变包括:任克式水肿(n=8),慢性喉炎(n=15),喉乳头状瘤(n=8),黏膜白斑(n=9),声带非典型性增生(n=18),恶性肿瘤(n=22),其他6例。结论接触性内镜作为一种新的微创性辅助检查方法,可用于喉癌及其癌前病变的诊断和动态随访。 | 李勇 Arens C Glanz H | 2005 | 中国中西医结合耳鼻咽喉科杂志2005，13，5： | 4 |
| 5 | Modeling the comfort effects of short-wave solar radiation indoors显示文摘 | Edward Arens Tyler Hoyt Xin Zhou Li Huang Hui Zhang Stefano Schiavon 侯恩哲 | 2015 | 建筑节能2015，43，6： | 3 |
| 6 | Mobility of a remobilised parabolic dune in Kennemerland, The Netherlands显示文摘 | S.M. Arens Q. Slings C.N. de Vries | 2003 | Geomorphology2003，，1： | 2 |
| 7 | In the name of the rose:a roadmap for rose research in the genome era显示文摘The recent completion of the rose genome sequence is not the end of a process,but rather a starting point that opens up a whole set of new and exciting activities.Next to a high-quality genome sequence other genomic tools have also become available for rose,including transcriptomics data,a high-density single-nucleotide polymorphism array and software to perform linkage and quantitative trait locus mapping in polyploids.Rose cultivars are highly heterogeneous and diverse.This vast diversity in cultivated roses can be explained through the genetic potential of the genus,introgressions from wild species into commercial tetraploid germplasm and the inimitable efforts of historical breeders.We can now investigate how this diversity can best be exploited and refined in future breeding work,given the rich molecular toolbox now available to the rose breeding community.This paper presents possible lines of research now that rose has entered the genomics era,and attempts to partially answer the question that arises after the completion of any draft genome sequence:‘Now that we have“the”genome,what’s next?’.Having access to a genome sequence will allow both(fundamental)scientific and(applied)breeding-orientated questions to be addressed.We outline possible approaches for a number of these questions. | Marinus J.M.Smulders Paul Arens Peter M.Bourke Thomas Debener Marcus Linde Jan De Riek Leen Leus Tom Ruttink Sylvie Baudino Laurence Hibrant Saint-Oyant Jeremy Clotault Fabrice Foucher | 2019 | Horticulture Research2019，6，1： | 2 |
| 8 | Is Extended Hepatectomy for Hepatobiliary Malignancy Justified?显示文摘 | Jean-Nicolas Vauthey Timothy M. Pawlik Eddie K. Abdalla James F. Arens Rabih A. Nemr Steven H. Wei Debra L. Kennamer Lee M. Ellis Steven A. Curley | 2004 | Annals of Surgery2004，，5： | 2 |
| 9 | Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases显示文摘 | Sebastian M. Dieter Claudia R. Ball Christopher M. Hoffmann Ali Nowrouzi Friederike Herbst Oksana Zavidij Ulrich Abel Anne Arens Wilko Weichert Karsten Brand Moritz Koch Jürgen Weitz Manfred Schmidt Christof von Kalle Hanno Glimm | 2011 | Cell Stem Cell2011，，4： | 2 |
| 10 | Aqueous extract of Ocimum tenuiflorum decreases levels of blood glucose in induced hyperglycemic tilapia(Oreochromis niloticus)显示文摘Objective:To evaluate,in hyperglycemic tilapia[Oreochromis niloticus(O.niloticus)].the effect of this aqueous extract on blood glucose levels.Methods:The hyperglycemia in O.niloticus was induced by adding glucose to fish pond water.An aqueous extract of Ocimum tenuiflorum (O.tenuiflorum) was prepared by boiling fresh leaves and the doses of 0,40,80,200 and 400 mg per liter of pond water were tested.Results:The blood sugar concentration for tilapia with hyperglycemic induced was an average of 50%higher than the control group.The blood glucose levels in tilapia after the induction of hyperglycemia were higher than the control group for 90 min after the treatment.The treatment with the aqueous extract of O.tenuiflorum dropped the serum glucose level of hyperglycemic tilapia until it was similar to that of the control group and was dose dependent.Conclusions:The results indicated that O.tenuiflorum was endowed with anti-hyperglycemic activity.To our knowledge,this is the first report on the use of fish as a diabetes model to test natural extracts from plants. | Amilcar Arenal Leonardo Martín Nestor M Castillo Dainier de la Torre Ubaldo Torres Reinaldo Gonzlez | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，8： | 2 |
| 11 | Transport rates and volume changes in a coastal foredune on a Dutch Wadden Island显示文摘 | Arens S M | 1997 | Journal of Coastal Conservation1997，3，1： | 1 |
| 12 | HER2/neu, p53, Ki67, and hormone receptors do not change during neoadjuvant chemotherapy in breast cancer显示文摘 | Arens N Bleyl U Hildenbrand R | 2005 | Virchows Arch2005，446，5： | 1 |
| 13 | Treatment of Churg-Strauss syndrome without poor prognosis factors: a muhicenter, prospective, randomized, open label study of seventy-two patients显示文摘 | Ribi C Cohen P Pagnoux C Mahr A Arene J P Lauque D | 2008 | Arthritis Rheum2008，58，： | 1 |
| 14 | Wound infections after cardiac surgery-a wound scoring system may improve early detection 显示文摘 | Tegnell A Aren C Ohman L | 2002 | Scand Cardiovasc J2002，36，1： | 1 |
| 15 | Hospi- tality and Tourism Journal Matrix 显示文摘 | Susan W Aren Swathi Ravichandr Eric Bro | | Journal of Hospitality & Tourism Education0，200，2： | 1 |
| 16 | The role of intra-perito-neal honey administration in preventing post-operative perito-neal adhesions显示文摘 | Aysan E Ayar E Aren A | 2002 | Eur J Obstet Gynecol Reprod Biol2002，104，2： | 1 |
| 17 | Acute and long-term outcome of transvenous cryoablation of midseptal and parahissian accessory pathways in patients at high risk of atrioventricular block during radiofrequency ablation显示文摘 | Atienza F Arenal A Torrecilla EG | 2004 | Am J Cardiol2004，93，10： | 1 |
| 18 | Mutations that extend the specificity of the endonuclease activity of lambda terminase显示文摘 | ARENS J S HANG Q HWANG Y | 1999 | J Bac-teriol1999，181，1： | 1 |
| 19 | Physiological effects of obstructive sleep apnea syndrome in childhood显示文摘 | Muzumdar H Arens R | 2013 | Respiratory physiology & neurobiology2013，188，3： | 1 |
| 20 | Intra and postoperative cerebral complications of open heart surgery显示文摘 | Johansson T Aren C Fransson SG | 1995 | Scand J Thorac Cardiovasc Surg1995，29，1： | 1 |
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