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| 1 | Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome显示文摘 | J. Matricon M. Meleine A. Gelot T. Piche M. Dapoigny E. Muller D. Ardid | 2012 | Aliment Pharmacol Ther (pt)2012，，11： | 6 |
| 2 | Evidence for an involvement of supra-spinal δ- and spinal μ-opioid receptors in the antihyperalgesic effect of chronically administred clomipramine in mononeuropathic rats显示文摘 | MARCHAND F ARDID D CHAPUY E | 2003 | J Pharmacol Exp Ther2003，307，1： | 1 |
| 3 | Interactive in-volvement of brain derived neurotrophic factor, nerve growthfactor, and calcitonin gene related peptide in colonic hypersen-sitivity in the rat显示文摘 | DELAFOY L GELOT A ARDID D | 2006 | Gut2006，55，7： | 1 |
| 4 | Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation显示文摘BACKGROUND Chronic abdominal pain is the most common cause for gastroenterology consultation and is frequently associated with functional gastrointestinal disorders including irritable bowel syndrome and inflammatory bowel disease. These disorders present similar brain/gut/microbiota trialogue alterations, associated with abnormal intestinal permeability, intestinal dysbiosis and colonic hypersensitivity(CHS). Intestinal dysbiosis can alter colon homeostasis leading to abnormal activation of the innate immunity that promotes CHS, perhaps involving the toll-like receptors(TLRs), which play a central role in innate immunity.AIM To understand the mechanisms between early life event paradigm on intestinal permeability, fecal microbiota composition and CHS development in mice with TLRs expression in colonocytes.METHODS Maternal separation model(NMS) CHS model, which mimics deleterious events in childhood that can induce a wide range of chronic disorders during adulthood were used. Colonic sensitivity of NMS mice was evaluated by colorectal distension(CRD) coupled with intracolonic pressure variation(IPV) measurement. Fecal microbiota composition was analyzed by 16S rRNA sequencing from weaning to CRD periods. TLR mRNA expression was evaluated in colonocytes.Additionally, the effect of acute intrarectal instillation of the TLR5 agonist flagellin(FliC) on CHS in adult naive wildtype mice was analyzed.RESULTS Around 50% of NMS mice exhibited increased intestinal permeability and CHS associated with intestinal dysbiosis, characterized by a significant decrease of species richness, an alteration of the core fecal microbiota and a specific increased relative abundance of flagellated bacteria. Only TLR5mRNA expression was increased in colonocytes of NMS mice with CHS. Acute intrarectal instillation of FliC induced transient increase of IPV, reflecting transient CHS appearance.CONCLUSION Altogether, these data suggest a pathophysiological continuum between intestinal dysbiosis and CHS, with a role for TLR5. | Geoffroy Mallaret Amandine Lashermes Mathieu Meleine Ludivine Boudieu Julie Barbier Youssef Aissouni Agathe Gelot Benoit Chassaing Andrew T Gewirtz Denis Ardid Frederic Antonio Carvalho | 2022 | World Journal of Gastroenterology2022，28，29： | 1 |
| 5 | Interactive involvement of brain derived neurotrophic factor,nerve growth factor,and calcitonin gene related peptide in colonic hypersensitivity in the rat显示文摘 | Delafoy L Gelot A Ardid D | 2006 | Gut2006，55，7： | 1 |
| 6 | Audible and ultrasonic vocalization elicited by single electrical nociceptive stimuli to the tail in the rat显示文摘 | Jourdan D Ardid D Chapuy E Eschalier A & Le Bars D | | 0，，： | 1 |
| 7 | Interactive involvement of brain derived neurotrophic factor, nerve growthfactor, and calcitonin gene related peptide in colonic hypersensitivity in the rat 显示文摘 | Delafoy L Gelot A Ardid D | 2006 | Gut2006，55，7： | 1 |
| 8 | Interactive involvement of brain derived neurotrophic factor, nerve growth factor,and calcitonin gene related peptide in colonic hypersensitivity in the rat 显示文摘 | Delafoy L Gelot A Ardid D | 2006 | Gut2006，55，7： | 1 |
| 9 | Interactive involvement of brain de- rived neurotrophic factor,nerve growth factor,and calcitonin gene relat- ed peptide in colonic hypersensitivity in the rat显示文摘 | Delafoy L Gelot A Ardid D | 2006 | Gut2006，55，7： | 1 |
| 10 | Interactive involvement of brain derived neurotrophic factor, nerve growth factor, and calcitonin gene related peptide in colonic hypersensitivity in the rat 显示文摘 | Delafoy L Gelot A Ardid D | 2006 | Gut2006，55，7： | 1 |
| 11 | Interactive involvement of brain derived neurotrophic factor, nerve growth factor, and caici- tonin gene related peptide in colonic hypersensitivity in the rat 显示文摘 | Delafoy L Gelot A Ardid D | 2006 | Gut2006，55，7： | 1 |
| 12 | Immunopathogenesis of inflammatory bowel disease显示文摘 | Matricon J Barnich N Ardid D | 2010 | Self Nonself2010，1，4： | 1 |
| 13 | Ultrasonic testing of the time evolution prop- erties of oranges显示文摘 | Camarena F Martinez JA Ardid M etal | 2005 | IEEE Ultrasonics Sym- posium2005，，： | 1 |
| 14 | Evidence for an involvement of supraspinal 6- and spinal μ-opioid receptors in the antihyperalgesic effect of chronically administered clomipramine in mononeuropathic rats显示文摘 | MARCHAND F ARDID D CHAPUY E et at | 2003 | J Pharrnacol Exp Ther2003，307，1： | 1 |
| 15 | Pharma-cological Studies of Ten Medicinal Plants Used for Analgesic Purposes inCongo Brazzaville显示文摘 | MAKAMBILA-KOUBEMBA M C MBATCHI B ARDID De t al | 2011 | International Journal of Pharmacology2011，7，5： | 1 |
| 16 | Evidence for an involvement of supra-spinal D-and spinal L-opioid recep- tors in the anti hyperalgesic effect of chronically adm inis- tered clomipramine in monon-europathic rats显示文摘 | Marchand F Ardid D Chapuye E | 2003 | J Phar- macol Exp Ther2003，307，1： | 1 |
| 17 | Antidepressants and pain显示文摘 | Mico JA Ardid D Berrocoso E | 2006 | Trends Pharmacol Sci2006，27，7： | 1 |
| 18 | Interactive involvement of brain derived neurotrophic factor, nerve growth factor, and calcitonin gene related peptide in colonic hypersensi- tivity in the rat显示文摘 | Delafoy L Gelot A Ardid D | 2006 | Gut2006，55，7： | 1 |
| 19 | Antidepressants and pain 显示文摘 | Mic6 JA Ardid D Berrocoso E | 2006 | Trends PharmacolSci2006，27，7： | 1 |
| 20 | Interactive involvement of brain derived neurotrophic factor, nerve growth factor, and calcitonin gene related peptide in colonic hypersensitivity in the rat 显示文摘 | Delafoy L Gelot A Ardid D | 2006 | Gut2006，55，7： | 1 |
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