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| 1 | Pathogenesis and management issues for non-alcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease (NAFLD) has, although it is a very common disorder, only relatively recently gained broader interest among physicians and scientists. Fatty liver has been documented in up to 10 to 15 percent of normal individuals and 70 to 80 percent of obese individuals. Although the pathophysiology of NAFLD is still subject to intensive research, several players and mechanisms have been suggested based on the substantial evidence. Excessive hepatocyte triglyceride accumulation resulting from insulin resistance is the first step in the proposed 'two hit' model of the pathogenesis of NAFLD. Oxidative stress resulting from mitochondrial fatty acids oxidation, NF-κB-dependent inflammatory cytokine expression and adipocytokines are all considered to be the potential factors causing second hits which lead to hepatocyte injury, inflammation and fibrosis. Although it was initially believed that NAFLD is a completely benign disorder, histologic follow-up studies have showed that fibrosis progression occurs in about a third of patients. A small number of patients with NAFLD eventually ends up with end-stage liver disease and even hepatocellular carcinoma. Although liver biopsy is currently the only way to confirm the NAFLD diagnosis and distinguish between fatty liver alone and NASH, no guidelines or firm recommendations can still be made as for when and in whom it is necessary. Increased physical activity, gradual weight reduction and in selected cases bariatric surgery remain the mainstay of NAFLD therapy. Studies with pharmacologic agents are showing promising results, but available data are still insufficient to make specific recommendations; their use therefore remains highly individual. | Marko Duvnjak Ivan Leroti Neven Bari Vedran Tomai Lucija Virovi Juki Vedran Velagi | 2007 | World Journal of Gastroenterology2007，13，34： | 74 |
| 2 | Metabolomic studies of human gastric cancer:Review显示文摘Metabolomics is a field of study in systems biology that involves the identification and quantification of metabolites present in a biological system. Analyzing metabolic differences between unperturbed and perturbed networks, such as cancerous and noncancerous samples, can provide insight into underlying disease pathology, disease prognosis and diagnosis. Despite the large number of review articles concerning metabolomics and its application in cancer research, biomarker and drug discovery, these reviews do not focus on a specific type of cancer. Metabolomics may provide biomarkers useful for identification of early stage gastric cancer, potentially addressing an important clinical need. Here, we present a short review on metabolomics as a tool for biomarker discovery in human gastric cancer, with a primary focus on its use as a predictor of anticancer drug chemosensitivity, diagnosis, prognosis, and metastasis. | Naresh Doni Jayavelu Nadav S Bar | 2014 | World Journal of Gastroenterology2014，20，25： | 19 |
| 3 | Serum and urine metabolomic fingerprinting in diagnostics of inflammatory bowel diseases显示文摘AIM:To evaluate the utility of serum and urine metabolomic analysis in diagnosing and monitoring of inflammatory bowel diseases(IBD).METHODS:Serum and urine samples were collected from 24 patients with ulcerative colitis(UC),19 patients with the Crohn’s disease(CD)and 17 healthy controls.The activity of UC was assessed with the Simple Clinical Colitis Activity Index,while the activity of CD was determined using the Harvey-Bradshaw Index.The analysis of serum and urine samples was performed using proton nuclear magnetic resonance(NMR)spectroscopy.All spectra were exported to Matlab for preprocessing which resulted in two data matrixes for serum and urine.Prior to the chemometric analysis,both data sets were unit variance scaled.The differences in metabolite fingerprints were assessed using partial least-squaresdiscriminant analysis(PLS-DA).Receiver operating characteristic curves and area under curves were used to evaluate the quality and prediction performance of the obtained PLS-DA models.Metabolites responsible for separation in models were tested using STATISTICA10 with the Mann-Whitney-Wilcoxon test and the Student’s t test(α=0.05).RESULTS:The comparison between the group of patients with active IBD and the group with IBD in remission provided good PLS-DA models(P value 0.002for serum and 0.003 for urine).The metabolites that allowed to distinguish these groups were:N-acetylated compounds and phenylalanine(up-regulated in serum),low-density lipoproteins and very low-density lipoproteins(decreased in serum)as well as glycine(increased in urine)and acetoacetate(decreased in urine).The significant differences in metabolomic profiles were also found between the group of patients with active IBD and healthy control subjects providing the PLS-DA models with a very good separation(P value<0.001 for serum and 0.003 for urine).The metabolites that were found to be the strongest biomarkers included in this case:leucine,isoleucine,3-hydroxybutyric acid,N-acetylated compounds,acetoacetate,glycine,phenylalanine and lactate(increased in serum),creatine,dimethyl sulfone,histidine,choline and its derivatives(decreased in serum),as well as citrate,hippurate,trigonelline,taurine,succinate and 2-hydroxyisobutyrate(decreased in urine).No clear separation in PLS-DA models was found between CD and UC patients based on the analysis of serum and urine samples,although one metabolite(formate)in univariate statistical analysis was significantly lower in serum of patients with active CD,and two metabolites(alanine and N-acetylated compounds)were significantly higher in serum of patients with CD when comparing jointly patients in the remission and active phase of the diseases.Contrary to the results obtained from the serum samples,the analysis of urine samples allowed to distinguish patients with IBD in remission from healthy control subjects.The metabolites of importance included in this case up-regulated acetoacetate and down-regulated citrate,hippurate,taurine,succinate,glycine,alanine and formate.CONCLUSION:NMR-based metabolomic fingerprinting of serum and urine has the potential to be a useful tool in distinguishing patients with active IBD from those in remission. | Tomasz Dawiskiba Stanislaw Deja Agata Mulak Adam Zabek Ewa Jawień Dorota Pawelka Miroslaw Banasik Agnieszka Mastalerz-Migas Waldemar Balcerzak Krzysztof Kaliszewski Jan Skóra Piotr Bar Krzysztof Korta Kornel Pormańczuk Przemyslaw Szyber Adam Litarski Piotr Mlynarz | 2014 | World Journal of Gastroenterology2014，20，1： | 15 |
| 4 | Overview and developments in noninvasive diagnosis of nonalcoholic fatty liver disease显示文摘High prevalence of non-alcoholic fatty liver disease (NAFLD) and very diverse outcomes that are related to disease form and severity at presentation have made the search for noninvasive diagnostic tools in NAFLD one of the areas with most intense development in hepatology today.Various methods have been investigated in the recent years,including imaging methods like ultrasound and magnetic resonance imaging,different forms of liver stiffness measurement,various biomarkers of necroinflammatory processes (acute phase reactants,cytokines,markers of apoptosis),hyaluronic acid and other biomarkers of liver fibrosis.Multicomponent tests,scoring systems and diagnostic panels were also developed with the purposes of differentiating non-alcoholic steatohepatitis from simple steatosis or discriminating between various fibrosis stages.In all of the cases,performance of noninvasive methods was compared with liver biopsy,which is still considered to be a gold standard in diagnosis,but is by itself far from a perfect comparative measure.We present here the overview of the published data on various noninvasive diagnostic tools,some of which appear to be very promising,and we address as well some of still unresolved issues in this interesting field. | Neven Bari Ivan Leroti Lea Smiri-Duvnjak Vedran Tomai Marko Duvnjak | 2012 | World Journal of Gastroenterology2012，18，30： | 7 |
| 5 | 盐胁迫环境下腐植酸类物质对小麦生长及矿物营养吸收的影响显示文摘对在不同浓度的盐胁迫条件下,叶面喷施液态腐植酸和土壤施用腐植酸类物质对小麦作物生长和矿物营养吸收的影响进行了研究。通过添加不同量的NaCl得到不同的盐浓度环境。腐植酸类物质在作物种植前一个月施用,液态腐植酸在种苗发芽后20d和35d喷施于小麦叶面。腐植酸类物质的施用量为0、1g/kg、2g/kg,液态腐植酸的浓度为0、0.1%、0.2%。盐度对小麦生长具有负面影响,它会降低小麦对除Na、Mn以外的矿物营养的吸收,影响小麦干重。通过在土壤施用腐植酸类物质可以增加小麦对N的吸收,叶面施用腐植酸可增加其对P、K、Mg、Na、Cu和Zn的吸收。研究结果显示:在土壤中施用腐植酸类物质,不同盐浓度与施用量之间存在较好的相关性,但叶面喷施时盐度和喷施量之间相关性并不明显。在盐胁迫环境的影响下,叶面喷施腐植酸的初始浓度和土壤中施用的腐植酸类物质的初施量都增加了作物对营养元素的吸收。 | Bar Bülent A k Murat Ali Turan Hakan elik Ali Vahap Katkat 刘海弟 | 2009 | 腐植酸2009，，6： | 6 |
| 6 | Soil Biota in the Arava Valley of Negev Desert,Israel显示文摘Soil microorganism biomass and respiration and the soil nematode community were observed in the hypersaline desert valley that is found between the Dead Sea and the Red Sea. The lowest point of the valley is approximately 400 m below sea level, and is the lowest point on earth. Soil samples (n = 72) were collected from the 0-10 and 10-20 cm soil layers at different altitudes (from -400 to +100 m) in the open spaces between plants during one of the most extreme xeric periods. Both soil microbial respiration and microbial biomass were found to be negatively dependent on soil moisture (SM) and organic matter (OM), and positively dependent on pH values. The physical-chemical characteristics of this hypersaline area were extremely unfavorable for the soil nematode communities, and the nematodes were entirely absent in the open area below sea level. The bacterivores were found to be the most resistant nematodes in this hyperarid region, with the Wilsonema being the most widespread genus. We suggest that nitrogen availability may play a crucial role in the below-ground soil interaction in this region, with bacterivore nematodes as indicators of nitrogen availability. | S. PEN-MOURATOV T. MYBLAT I. SHAMIR G. BARNESS Y. STEINBERGER | 2010 | Pedosphere2010，20，3： | 4 |
| 7 | Genetic polymorphisms in non-alcoholic fatty liver disease:Clues to pathogenesis and disease progression显示文摘The spectrum of non-alcoholic fatty liver disease(NAFLD) ranges from simple steatosis through steatohepatitis to advanced f ibrosis and cirrhosis.Although the reason why only a minority of patients develop progressive forms of disease still remains largely unclear,recent research has identified genetic factors as a possible basis for this variation in disease presentation.Most of the studies have been focused on f inding associations between advanced disease forms and selected single nucleotide polymorphisms in genes encoding various proteins involved in disease pathogenesis.Although there are many limitations regarding the study design and interpretation of published data,further carefully planned studies together with implementation of new genetic technologies will likely bring new insights into disease pathogenesis and potential benefits to the management of patients with NAFLD. | Marko Duvnjak Neven Bari Vedran Tomai Ivan Leroti | 2009 | World Journal of Gastroenterology2009，15，48： | 4 |
| 8 | A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia—a preliminary report 1 1 Original Contributions is coordinated by John A. Marx , MD, of Carolinas Medical Center, Charlotte, North Carolina显示文摘 | David Bar–Or Edward Lau James V Winkler | 2000 | Journal of Emergency Medicine2000，，4： | 3 |
| 9 | Cyclodextrin-enhanced degradation of toluene and p-toluic acid by pseudomonas putida显示文摘 | Schwartz A Bar R | 1995 | Applied Microbiology and Biotechnology1995，61，7： | 2 |
| 10 | 非洲投资仲裁的演变显示文摘引言随着非洲逐步融入全球经济,以及它在国际争端纠纷解决方面的经验日益丰富,非洲投资仲裁正面临转型。近年来,非洲为成为一个有吸引力的投资目的地作出了巨大的努力。根据联合国贸易和发展会议(UNCTAD)发布的《2017年世界投资报告》,非洲在2016年吸引了590亿美元的外国直接投资,占全球总投资额的3.4%。 | Benoit Le Bars 艾昕语(译) 朱伟东(校) | 2020 | 北京仲裁2020，，2： | 2 |
| 11 | 依诺肝素对具有流产与血栓形成倾向妇女晚期妊娠并发症及新生儿结局的影响:Live-Enox研究结果显示文摘Women with thrombophilia and a history of recurrent pregnancy loss have poor pregnancy outcomes. Prophylaxis with enoxaparin 40 mg/day or 80 mg/day resulted in favorable gestational and neonatal outcomes. | Brenner B. Bar J. Ellis M. 李跃萍 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，2： | 2 |
| 12 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 13 | 针刺镇痛与弥漫性伤害抑制性控制显示文摘用微电极记录大鼠三叉神经尾侧核会聚神经元活动,电刺激感受野中心可以诱发A和C类纤维的传入反应。用48℃热水浸烫大鼠后肢可明显抑制会聚神经元C类纤维的传入反应,并有明显的后抑制效应。这种效应已被命名为弥漫性伤害抑制性控制(DNIC)。手针“足三里”和非穴位也能明显抑制会聚神经元C类纤维的传入反应,后抑制效应更明显而持久。提示针刺镇痛涉及到DNIC。这些效应均可部分被纳洛酮拮抗。 | 朱兵 L. Villanueva D. Le Bars | 1991 | 江西医学院学报1991，31，2： | 2 |
| 14 | Productivity growth in OECD countries: A comparison with Malmquist indices显示文摘 | Bar?? K. Y?rük Osman Zaim | 2005 | Journal of Comparative Economics2005，，2： | 2 |
| 15 | Characterization of monascidin A from Monascus as citrinin显示文摘 | P.J. Blanc J.P. Laussac J. Le Bars P. Le Bars M.O. Loret A. Pareilleux D. Prome J.C. Prome A.L. Santerre G. Goma | 1995 | International Journal of Food Microbiology1995，，2： | 2 |
| 16 | Rapid and robust slope failure appraisal using aerial photogrammetry and 3D slope stability models显示文摘Slope failures are an inevitable aspect of economic pit slope designs in the mining industry.Large open pit guidelines and industry standards accept up to 30%of benches in open pits to collapse provided that they are controlled and that no personnel are at risk.Rigorous ground control measures including real time monitoring systems at TARP(trigger-action-response-plan)protocols are widely utilized to prevent personnel from being exposed to slope failure risks.Technology and computing capability are rapidly evolving.Aerial photogrammetry techniques using UAV(unmanned aerial vehicle)enable geotechnical engineers and engineering geologists to work faster and more safely by removing themselves from potential line-of-fire near unstable slopes.Slope stability modelling software using limit equilibrium(LE)and finite element(FE)methods in three dimensions(3D)is also becoming more accessible,user-friendly and faster to operate.These key components enable geotechnical engineers to undertake site investigations,develop geotechnical models and assess slope stability faster and in more detail with less exposure to fall of ground hazards in the field.This paper describes the rapid and robust process utilized at BHP Limited for appraising a slope failure at an iron ore mine site in the Pilbara region of Western Australia using a combination of UAV photogrammetry and 3D slope stability models in less than a shift(i.e.less than 12 h). | Neil Bar Michael Kostadinovski Michael Tucker Glen Byng Rully Rachmatullah Arturo Maldonado Markus Pötsch Andreas Gaich Alison McQuillan Thamer Yacoub | 2020 | International Journal of Mining Science and Technology2020，30，5： | 2 |
| 17 | Barrett's esophagus with high grade dysplasia is associated with non-esophageal cancer显示文摘AIM To study factors associated with esophageal and nonesophageal cancer morbidity among Barrett's esophagus(BE) patients. METHODS A cohort study within a single tertiary center included 386 consecutive patients with biopsy proven BE, who were recruited between 2004-2014. Endoscopic and histologic data were prospectively recorded. Cancer morbidity was obtained from the national cancer registry. Main outcomes were BE related(defined as esophagus and cardia) and non-BE related cancers(all other cancers). Cancer incidence and all-causemortality were compared between patients with highgrade dysplasia(HGD) and with low-grade or no dysplasia(non-HGD) using Kaplan-Meier curves and cox regression models.RESULTS Of the 386 patients, 12 had HGD, 7 had a BE related cancer. There were 75(19.4%) patients with 86 cases of lifetime cancers, 76 of these cases were non-BE cancers. Seven(1.8%) and 18(4.7%) patients had BE and non-BE incident cancers, respectively. Twelve(3.1%) patients had HGD as worst histologic result. Two(16.7%) and 16(4.4%) incident non-BE cancers occurred in the HGD and non-HGD group, respectively. Ten-year any cancer and non-BE cancer free survival was 63% and 82% in the HGD group compared to 93% and 95% at the non-HGD group, respectively. Log-rank test for patients with more than one endoscopy, assuring longer follow up, showed a significant difference(P < 0.001 and P = 0.017 respectively). All-cause mortality was not significantly associated with BE HGD.CONCLUSION Patients with BE and HGD, may have a higher risk for all-cause cancer morbidity. The implications on cancer prevention recommendations should be further studied. | Nir Bar Naama Schwartz Michal Nissim Naomi Fliss-Isacov Shira Zelber-Sagi Revital Kariv | 2018 | World Journal of Gastroenterology2018，24，39： | 2 |
| 18 | Effect of sodium replacement on the quality characteristics of pastırma(a dry-cured meat product)显示文摘This study aims to investigate the effect of sodium replacement on the quality characteristics of pastırma.For this purpose,pastırma production with four different salt mixtures(Ⅰ.100%NaCl;Ⅱ.50%NaCl+50%KCl;Ⅲ.40%NaCl+40%KCl+20%CaCl_(2);Ⅳ.30%NaCl+40%KCl+20%CaCl_(2)+10%MgCl_(2))were carried out using traditional method.The use of different salt mixtures for pastırma had no statistically significant effect on the microbial counts and residual nitrite of the final product.The a*and b*values were affected by this treatment.The salt mixture containing CaCl_(2) or CaCl_(2)+MgCl_(2) significantly decreased the pH values and sensory scores.The eighteen volatile compounds were affected by the salt mixtures.Na^(+),K^(+),Ca^(2+),and Mg^(2+)had a certain increase depending on their ratio in the salt mixtures.The highest Cathepsin activity in all pastırma samples was observed in Cathepsin B+L.The salt mixture with NaCl+KCl+CaCl_(2)+MgCl_(2) increased acid lipase activity.However,this mixture had no significant effect on neutral lipase activity. | BarışYalınkılıç Güzin Kaban Mükerrem Kaya | 2023 | Food Science and Human Wellness2023，12，1： | 2 |
| 19 | Thermal Frontiers in the Design and Packaging Microelectronic Equipment显示文摘 | Cohen A Bar Kraus A D Davidson S F | 1983 | Mechanical Engineering1983，105，6： | 1 |
| 20 | Efficacy,tolerability,and effects on quality of life of losartan,alone or with hydrochlorothiazide,in patients with essential hypertension显示文摘 | Bar E Elkins M | 1996 | Clin Ther1996，18，： | 1 |
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