|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gender-related differences in irritable bowel syndrome: Potential mechanisms of sex hormones显示文摘According to epidemiological studies,twice as many women as men are affected by irritable bowel syndrome(IBS)in western countries,suggesting a role for sex hormones in IBS pathophysiology.Despite growing evidence about the implications of sex hormones in IBS symptom modulation,data on mechanisms by which they influence disease development are sparse.This review aims to determine the state of knowledge about the role of sex hormones in sensorimotor dysfunctions and to address the possible interplay of sex hormones with common risk factors associated with IBS.The scientific bibliography was searched using the following keywords:irritable bowel syndrome,sex,gender,ovarian hormone,estradiol,progesterone,testosterone,symptoms,pain,sensitivity,motility,permeability,stress,immune system,brain activity,spinal,supraspinal,imaging.Ovarian hormones variations along themenstrual cycle affect sensorimotor gastrointestinal function in both healthy and IBS populations.They can modulate pain processing by interacting with neuromodulator systems and the emotional system responsible for visceral pain perception.These hormones can also modulate the susceptibility to stress,which is a pivotal factor in IBS occurrence and symptom severity.For instance,estrogen-dependent hyper-responsiveness to stress can promote immune activation or impairments of gut barrier function.In conclusion,whereas it is important to keep in mind that ovarian hormones cannot be considered as a causal factor of IBS,they arguably modulate IBS onset and symptomatology.However,our understanding of the underlying mechanisms remains limited and studies assessing the link between IBS symptoms and ovarian hormone levels are needed to improve our knowledge of the disease evolution with regard to gender.Further studies assessing the role of male hormones are also needed to understand fully the role of sex hormones in IBS.Finally,investigation of brain-gut interactions is critical to decipher how stress,ovarian hormones,and female brain processing of pain can translate into gut dysfunctions. | Mathieu Meleine Julien Matricon | 2014 | World Journal of Gastroenterology2014，20，22： | 14 |
| 2 | Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome显示文摘 | J. Matricon M. Meleine A. Gelot T. Piche M. Dapoigny E. Muller D. Ardid | 2012 | Aliment Pharmacol Ther (pt)2012，，11： | 6 |
| 3 | Immunopathogenesis of inflammatory bowel disease显示文摘 | Matricon J | 2010 | Med Sci(Paris)2010，26，： | 1 |
| 4 | Review article:Associations between immune activation,intestinal permeability and the irritable bowel syndrome显示文摘 | Matricon J Meleine M Gelot A | 2012 | Aliment Pharmacol Ther2012，36，1112： | 1 |
| 5 | Immunopathogenesis of inflammatory bowel disease显示文摘 | Matricon J Barnich N Ardid D | 2010 | Self Nonself2010，1，4： | 1 |
| 6 | Identifying terrorist attack victims显示文摘The terrorist attacks that occurred in France in 2015 and 2016,which had many victims,proved that it is essential to identify victims following the methodology developed by International Criminal Police Organization(INTERPOL)for such events.Initially designed for natural disasters,this approach must be strictly respected should a terrorist attack occur.This includes the specific collection of bodies and body parts,as well as the setup of an antemortem unit,postmortem unit,and Identification Commission.This commission is made up of specialists and will make decisions on the basis of primary identifying elements(fingerprints,DNA,dental records)and/or secondary identifying elements(other distinctive and particularly discriminating signs).A multidisciplinary team,combining specifically trained police officers and scientists,must provide a reliable and consolidated list of deceased people based on biometric elements cross checked with elements from the investigations.Any list of names generated on another basis should be excluded.Identification of the deceased by relatives(visual recognition),even if the bodies do not appear mutilated and/or decayed,should be avoided to avert erroneous death announcements,body presentations,or even burials or cremations.Similarly,identifying victims only on the basis of their personal effects(such as an identity card)must be absolutely avoided.All bodies,even those whose identities seem obvious to the first responders or to the relatives,must be registered as“X”during the crime scene search and properly identified according to the INTERPOL protocol.The same protocol should be applied to unconscious injured people.Considering the expectations of our modern society for rapid information circulation and quick responses from the authorities,the French team has made a few adjustments to speed up the identification process without compromising its integrity.Validated and supported by both the French judicial and administrative authorities in the light of the experience of the November 2015 attacks in Paris,this innovative method proved its effectiveness during the Nice attack in July 2016.It can only be successful in a context where all the individuals involved in the crisis,up to the highest authorities,understand it,support it,and relay it in the best interest of the victims’families. | Elvire Arrighi Amandine Matricon Charlot | 2020 | Forensic Sciences Research2020，5，3： | 1 |
| 7 | Differential involvement of ASICla in the basolateral amygdala in fear memory and unconditioned fear re- sponses 显示文摘 | Gregoire S Matricon J | 2009 | J Neurosci2009，29，19： | 1 |
| 8 | Review article:associations between immune activation,intestinal permeability and the irritable bowel syndrome显示文摘 | Matricon J Meleine M Gelot A | 2012 | Aliment Pharmacol Ther2012，36，1112： | 1 |
| 9 | Review artcle:associations be-tween immune activation,intestinal permeability and the irritable bow-el ayndrome 显示文摘 | Matricon J Meleine M Gelot A | 2012 | Aliment Pharmacol Ther2012，36，1112： | 1 |
| 10 | Peripheral contribution of NGF and ASIC 1a to colonic hypersensitivity in a rat model of irritable bowel syndrome显示文摘 | J. Matricon E. Muller A. Accarie M. Meleine M. Etienne N. Voilley J. Busserolles A. Eschalier M. Lazdunski S. Bourdu A. Gelot D. Ardid | 2013 | Neurogastroenterol. Motil2013，，11： | 1 |
| 11 | Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome显示文摘 | MATRICON J MELEINE M GELO T A | 2012 | Alimentary Pharmacology & Therapeutics2012，36，1112： | 1 |
| 12 | Comparative effects of α2δ-1 ligands in mouse models of colonic hypersensitivity显示文摘AIM: To investigate anti-hypersensitive effects of α2δ-1 ligands in non-inflammatory and inflammationassociated colonic hypersensitivity(CHS) mouse models.METHODS: To induce an inflammation-associated CHS, 1% dextran sulfate sodium(DSS) was administered to C57Bl/6J male mice, in drinking water, for 14 d. Regarding the non-inflammatory neonatal maternal separation(NMS)-induced CHS model, wild-type C57BI/6J pups were isolated from their mother from day 2 to day 14(P2 to P14), three hours per day(from 9:00 a.m. to 12:00 p.m.). Colorectal distension was performed by inflating distension probe from 20 μL to 100 μL by 20 μL increment step every 10 s. After a first colorectal distension(CRD), drugs were administered subcutaneously, in a cumulative manner,(Gabapentin at 30 mg/kg and 100 mg/kg; Pregabalin at 10 mg/kg and 30 mg/kg; Carbamazepine at 10 mg/kg and 30 mg/kg) and a second CRD was performed one hour after each injection.RESULTS: The visceromotor response(VMR) to CRD was increased by our NMS paradigm protocol in comparison to non-handled(NH) mice, considering the highest distension volumes(80 μL: 0.783 ± 0.056 mV /s vs 0.531 ± 0.034 m V/s, P < 0.05 and 100 μL: 1.087 ± 0.056 m V/s vs 0.634 ± 0.038 m V/s, P < 0.05 for NMS and NH mice, respectively). In the inflammationassociated CHS, DSS-treated mice showed a dramatic and significant increase in VMR at 60 and 80 μL distension volumes when compared to control mice(60 μL: 0.920 ± 0.079 m V/s vs 0.426 ± 0.100 m V/s P < 0.05 and 80 μL: 1.193 ± 0.097 mV /s vs 0.681 ± 0.094 mV /s P < 0.05 for DSS- and Water-treated mice, respectively). Carbamazepine failed to significantly reduce CHS in both models. Gabapentin significantly reduced CHS in the DSS-induced model for both subcutaneous injections at 30 or 100 mg/kg. Pregabalin s i g n i f i c a n t l y r e d u c e d V M R t o C R D i n t h e n o n-inflammatory NMS-induced CHS model for the acute subcutaneous administration of the highest cumulative dose(30 mg/kg) and significantly reduced CHS in lowdose DSS-treated mice in a dose-dependent manner. Finally, the percent decrease of AUC induced by acute GBP or Pregabalin treatment were higher in the inflammatory DSS-induced CHS model in comparison to the non-inflammatory NMS-induced CHS model.CONCLUSION: This preclinical study demonstrates α2δ-1 ligands efficacy on inflammation-associated CHS, highlighting their potential clinical interest in patients with chronic abdominal pain and moderate intestinal inflammation. | Mathieu Meleine Ludivine Boudieu Agathe Gelot Emilie Muller Amandine Lashermes Julien Matricon Celine Silberberg Vassilia Theodorou Alain Eschalier Denis Ardid Frederic A Carvalho | 2016 | World Journal of Gastroenterology2016，22，31： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员