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| 1 | Cytokine- and chemokine-induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy显示文摘Colorectal cancer(CRC)is a predominant life-threatening cancer,with liver and peritoneal metastases as the primary causes of death.Intestinal inflammation,a known CRC risk factor,nurtures a local inflammatory environment enriched with tumor cells,endothelial cells,immune cells,cancer-associated fibroblasts,immunosuppressive cells,and secretory growth factors.The complex interactions of aberrantly expressed cytokines,chemokines,growth factors,and matrix-remodeling enzymes promote CRC pathogenesis and evoke systemic responses that affect disease outcomes.Mounting evidence suggests that these cytokines and chemokines play a role in the progression of CRC through immunosuppression and modulation of the tumor microenvironment,which is partly achieved by the recruitment of immunosuppressive cells.These cells impart features such as cancer stem cell-like properties,drug resistance,invasion,and formation of the premetastatic niche in distant organs,promoting metastasis and aggressive CRC growth.A deeper understanding of the cytokineand chemokine-mediated signaling networks that link tumor progression and metastasis will provide insights into the mechanistic details of disease aggressiveness and facilitate the development of novel therapeutics for CRC.Here,we summarized the current knowledge of cytokine-and chemokine-mediated crosstalk in the inflammatory tumor microenvironment,which drives immunosuppression,resistance to therapeutics,and metastasis during CRC progression.We also outlined the potential of this crosstalk as a novel therapeutic target for CRC.The major cytokine/chemokine pathways involved in cancer immunotherapy are also discussed in this review. | Ajaz A.Bhat Sabah Nisar Mayank Singh Bazella Ashraf Tariq Masoodi Chandra P.Prasad Atul Sharma Selma Maacha Thasni Karedath Sheema Hashem Syed Besina Yasin Puneet Bagga Ravinder Reddy Michael P.Frennaux Shahab Uddin Punita Dhawan Mohammad Haris Muzafar A.Macha | 2022 | Cancer Communications2022，42，8： | 8 |
| 2 | Development of polyvinylpyrrolidone/paclitaxel self-assemblies for breast cancer显示文摘The goal of this investigation was to develop and demonstrate a polymer/paclitaxel selfassembly(PTX-SA) formulation. Polymer/PTX-SAs were screened based on smaller size of formulation using dynamic light scattering analysis. Additionally, fluorescence microscopy and flow cytometry studies exhibited that polyvinylpyrrolidone(PVP)-based PTX-SAs(PVP/PTX-SAs) had superior cellular internalization capability in MCF7 and MDA-MB-231 breast cancer cells. The optimized PVP/PTXSAs exhibited less toxicity to human red blood cells indicating a suitable formulation for reducing systemic toxicity. The formation of PVP and PTX self-assemblies was confirmed using fluorescence quenching and transmission electron microscopy which indicated that the PVP/PTX-SAs were spherical in shape with an average size range of 53.81 nm as detected by transmission electron microscopy(TEM).FTIR spectral analysis demonstrates incorporation of polymer and paclitaxel functional groups in PVP/PTX-SAs. Both proliferation(MTS) and clonogenic(colony formation) assays were used to validate superior anticancer activity of PVP/PTX-SAs in breast cancer cells over paclitaxel. Such superior anticancer activity was also demonstrated by downregulation of the expression of pro-survival protein(Bcl-x L), upregulation of apoptosis-associated proteins(Bid, Bax, cleaved caspase 7, and cleaved PARP)and β-tubulin stabilization. These results support the hypothesis that PVP/PTX-SAs improved paclitaxel delivery to cancer cells. | Pallabita Chowdhury Prashanth K.B.Nagesh Sheema Khan Bilal B.Hafeez Subhash C.Chauhan Meena Jaggi Murali M.Yallapu | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 7 |
| 3 | Stereotactic Hypofractionated Radiation Therapy as a Bridge to Transplantation for Hepatocellular Carcinoma: Clinical Outcome and Pathologic Correlation显示文摘 | Alan W. Katz Sheema Chawla Zhenhong Qu Randeep Kashyap Michael T. Milano Aram F. Hezel | 2012 | International Journal of Radiation Oncology Biology Physics2012，，3： | 2 |
| 4 | High-density positive electrodescontaining carbon nanotubes for use in Li-ion cells 显示文摘 | SHEEMA K LEE Y H LIM H S | 2006 | J Power Sour- ces2006，158，1： | 1 |
| 5 | Predicting the distribution of the Asian tapir in Peninsular Malaysia using maximum entropy modeling显示文摘In 2008,the IUCN threat status of the Asian tapir(Tapirus indicus)was reclasified from‘vulnerable'to‘en-dangered'.The latest distribution map from the IUCN Red List suggests that the tapirs'native range is becom-ing increasingly fragmented in Peninsular Malaysia,but distribution data collected by local researchers sug-gest a more extensive geographical range.Here,we compile a database of 1261 tapir occurrence records within Peninsular Malaysia,and demonstrate that this species,indeed,has a much broader geographical range than the IUCN range map suggests.However,extreme spatial and temporal bias in these records limits their utility for conservation planning.Therefore,we used maximum entropy(MaxEnt)modeling to elucidate the potential ex-tent of the Asian tapir's occurrence in Peninsular Malaysia while accounting for bias in existing distribution data.Our MaxEnt model predicted that the Asian tapir has a wider geographic range than our fine-scale data and the IUCN range map both suggest.Approximately 37%of Peninsular Malaysia contains potentially suit-able tapir habitats.Our results justify a revision to the Asian tapir's extent of occurrence in the IUCN Red List.Furthermore,our modeling demonstrated that selectively logged forests encompass 45%of potentially suitable tapir habitats,underscoring the importance of these habitats for the conservation of this species in Peninsular Malaysia. | Gopalasamy Reuben CLEMENTS D.Mark RAYAN Sheema Abdul AZIZ Kae KAWANISHI Carl TRAEHOLT David MAGINTAN Muhammad Fadlli Abdul YAZI Reid TINGLEY | 2012 | Integrative Zoology2012，7，4： | 1 |
| 6 | Exposing Transient Secrets and Detecting Malware Variants Using Control and Data Flow Analysis显示文摘 | ANJU S SHEEMA M JAYAKUMAR P | 2014 | International Journal of Computer Engineering & Technology (IJCET)2014，5，12： | 1 |
| 7 | Fetal alcohol spectrum disorder-associated depression : evidence for reductions in the levels of brain-derived neurotrophic factor in a mouse model 显示文摘 | Caldwell KK Sheema S Paz RD | 2008 | Pharmacol Biochem Behav2008，90，4： | 1 |
| 8 | Stereotactic Hypofractionated Radiation Therapy as a Bridge to Transplantation for Hepatocellular Carcinoma: Clinical Outcome and Pathologic Correlation显示文摘 | Alan W. Katz Sheema Chawla Zhenhong Qu Randeep Kashyap Michael T. Milano Aram F. Hezel | 2012 | International Journal of Radiation Oncology Biology Physics2012，，3： | 1 |
| 9 | Fetal alcohol spectrum disorder-associated depression:evidence for reductions in the levels of brain-derived neurotrophic factor in a mouse model显示文摘 | Caldwell KK Sheema S Paz RD | | 0，，04： | 1 |
| 10 | Organic micro-pollutant removal in liquid-phase using carbonized silk cotton hull显示文摘Phenolic compounds constitute one of the major pollutants in the modern world. Although many physical and chemical treatment technologies for their removal exist, most of them are economically not feasible. The present study was aimed at using silk cotton hull, a potent agricultural waste as an adsobent for removal of 2,4-dichlorophenol (2,4-DCP), which was used as a model phenolic compound. The process parameters were investigated and optimized conditions were determined. The equilibrium time was found to be 60 and 80 min for 10 and 20 mg/L and 100 min for 30 and 40 mg/L 2,4-DCP concentrations, respectively. Among the kinetic models applied, pseudo-second order model fitted well. The maximum adsorption capacity was 16.0 mg/g by Langmuir isotherm. Acidic pH was found favorable for the adsorption of 2,4-DCP. Studies on pH effect and desorption seemed to show that chemisorption played a major role in the adsorption process. In thermodynamic study, the change in entropy (△S 0) and heat of adsorption (△H0) of silk cotton hull carbon (SCHC) was estimated as 14.01 J/(mol·K) and 3.04 kJ/mol, respectively. SCHC as adsorbent for removal of 2,4-DCP from aqueous solution, is effective, inexpensive, indigenous, reusable, has low treatment time and is easily available in large quantities as waste there by significantly lowers the cost of wastewater treatment. | M Sathishkumar A R Binupriya D Kavitha R Selvakumar K K Sheema J G Choi | 2008 | Journal of Environmental Sciences2008，20，9： | 1 |
| 11 | Fetal alcohol spectntm disorder-associated depression: evidence for reductions in the levels of brain-derived neurotrophic factor in a mouse model 显示文摘 | Caldwell KK Sheema S Paz RD | 2008 | Pharmacol Bioehem Behav2008，90，4： | 1 |
| 12 | Effect of repeated impulses on transformer insulation 显示文摘 | BALAJI S P SHEEMA I KRITHIKA G | 2011 | IEEE Transactions on Dielectrics and Electrical Insula- tion2011，18，6： | 1 |
| 13 | Fetal alcohol spectrum disorder-associated depression: evidence for reductions in the levels of brain-derived neurotrophic factor in a mouse model 显示文摘 | Caldwell KK Sheema S Paz RD | 2008 | Pharmacol Biochem Behav2008，90，： | 1 |
| 14 | Effect of repeated impulses on transformer insulation显示文摘 | Balaji S P Sheema I P M Krithika G | 2011 | IEEE Transactions on Dielectrics and Electrical Insulation2011，18，6： | 1 |
| 15 | Estimating the population density of the Asian tapir (Tapirus indicus) in a selectively logged forest in Peninsular Malaysia显示文摘The endangered Asian tapir(Tapirus indicus)is threatened by large-scale habitat loss,forest fragmentation and increased hunting pressure.Conservation planning for this species,however,is hampered by a severe paucity of information on its ecology and population status.We present the first Asian tapir population density estimate from a camera trapping study targeting tigers in a selectively logged forest within Peninsular Malaysia using a spatially explicit capture-recapture maximum likelihood based framework.With a trap effort of 2496 nights,17 individuals were identified corresponding to a density(standard error)estimate of 9.49(2.55)adult ta-pirs/100 km2.Although our results include several caveats,we believe that our density estimate still serves as an important baseline to facilitate the monitoring of tapir population trends in Peninsular Malaysia.Our study also highlights the potential of extracting vital ecological and population information for other cryptic individual-ly identifiable animals from tiger-centric studies,especially with the use of a spatially explicit capture-recapture maximum likelihood based framework. | D.Mark RAYAN Shariff Wan MOHAMAD Leejiah DORWARD Sheema Abdul AZIZ Gopalasamy Reuben CLEMENTS Wong Chai Thiam CHRISTOPHER Carl TRAEHOLT David MAGINTAN | 2012 | Integrative Zoology2012，7，4： | 0 |
| 16 | Understanding bat ecosystem services on a global scale requires caution and wider collaboration:a critical evaluation of Ramírez-Fráncel et al.(2022)显示文摘Global biodiversity is currently in the midst of the sixth mass extinction,and countless species and their key ecosystem services are threatened across different habitats(Vos et al.2015).Constructive actions to address the negative impacts of changing conditions require rigorous biodiversity data integration and synthesis to inform effective policy-making decisions(Heberling et al.2021).Care is needed to ensure objectivity and remove biases in analyses to avoid generating misleading conclusions.Recently,Ramírez-Fráncel et al.(2022)published a review offering an update on the vital ecosystem services of bats on a global scale.We applaud the authors for their attempt to conduct an extremely challenging large-scale analysis in major areas of bat ecosystem services. | Krizler C.TANALGO Kim MCCONKEY Paul RACEY Sheema Abdul AZIZ Tuanjit SRITONGCHUAY Alice CHUGHES Tammy MILDENSTEIN | 2023 | Integrative Zoology2023，18，2： | 0 |
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