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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Serum S100B is suitable for prediction and monitoring of response to chemoimmunotherapy in metastatic malignant melanoma显示文摘 | Korse CM Bonfrer JM | 2003 | Melanoma Res2003，13，1： | 1 |
| 3 | NSP4 elicits agedependent diarrhea and Ca (2^+) mediated I (-) influx into intestinal crypts of CF mice 显示文摘 | Morris AP Scott JK Ball JM | 1999 | Am J Physiol1999，277，21： | 1 |
| 4 | Fatigue strength: effeet of welding type and joint design executed in Ti-6A1-4V structures显示文摘 | Pantoja JM Farina AP Vaz LG | 2012 | Gerodontology2012，29，2： | 1 |
| 5 | Brain gamma- ami- nobutyric acid (GABA) abnormalities in bipolar disorder显示文摘 | Brady RJ Mccarthy JM Prescot AP | 2013 | Bi- polar Disord2013，15，4： | 1 |
| 6 | Proposal for standardized criteria for the diagnosis of benign,borderline,and malignant hepatocellular lesions arising in chronic advanced liver disease显示文摘 | Ferrel LD Crawford JM Dhillon AP | 1993 | Am J Surg Pathol1993，17，： | 1 |
| 7 | c-myc is an important direct target of Notchl in T-cell acute lymphoblastic leukemia/lymphoma显示文摘 | Weng AP Millholland JM Yashiro-Ohtani Y | | 0，，15： | 1 |
| 8 | Association of anti- PLA2 R antibodies with outcomes after immunosuppressive therapy in idiopathic membranous nephropathy 显示文摘 | Bech AP Hofstra JM Brenchley PE | 2014 | Clin J Am Soc Nephrol2014，9，8： | 1 |
| 9 | Nodular primary localized cutaneous amyloidosis:immunohistochemical evaluation and treatment with the carbon dioxide laser显示文摘 | Truhan AP Garden JM Roenigk HH | 1986 | J Am Acad Demmtol1986，14，： | 1 |
| 10 | Transcription factor NF-kB inglomerulonephritis显示文摘 | Russell BA Stuart JM David AP | 2000 | Nephrology2000，5，12： | 1 |
| 11 | Induced abortion: a risk factor tor placenta previa 显示文摘 | Barrett JM Boehm FH Killam AP | 1981 | American Journal of Obstetrics and Gynecology1981，141，7： | 1 |
| 12 | Radiofrequency catheter modification of the sinus node for 'Inappropriate'sinus tachycardia显示文摘 | Lee RJ Kalman JM Fitzpatrick AP | 1995 | Circulation1995，92，： | 1 |
| 13 | Analysis of the agency for heahhcare research and quality patient safety indicators in public hospitals of the Autonomous Region of Madrid (Spain) 显示文摘 | Merchante JM Vega AM Hernandez AP | 2010 | Med Clin (Barc)2010，1351，： | 1 |
| 14 | A phase II study of fixed -dose rate gemcitabine plus low- dose cisplatin fol- lowed by consolidative chemoradiation for locally advanced pancreatic cancer显示文摘 | KO AH QUIVEY JM VENOOK AP | 2007 | Int J Radiat Oncol Biol Phys2007，68，3： | 1 |
| 15 | Feeling good-doing good:a conceptual analysis of the mood at ork-organizational spontaneity relationship显示文摘 | George JM Brief AP | 1992 | Psychological bulletin1992，，： | 1 |
| 16 | NCCN Clinical Practice Guidelines in Oncology:rectal cancer 显示文摘 | Engstrom PF Arnoletti JP Benson AB 3rd Chen YJ Choti MA Cooper HS Covey A Dilawari RA Early DS Enzinger PC Fakih MG Fleshman J Jr Fuchs C Greta JL Kiel K Knol JA Leong LA Lin E Mulcahy MF Rao S Ryan DP Saltz L Shibata D Skibber JM Sofocleous C Thomas J Venook AP Willett C | 2009 | J Natl Compr Canc Netw2009，7，： | 1 |
| 17 | Thera-peutic intervention for chronic prostatitis/chronic pelvic pain syn- drome (CP/CPPS) : a systematic review and meta-analysis显示文摘 | Cohen JM Fagin AP Hariton E | 2012 | PLos 0ne2012，7，41： | 1 |
| 18 | The stable nitroxide tempol facilitates salivary gland protection during head and neck irradiation in a mouse modal显示文摘 | Vitolo JM Cotrim AP Sowers AL | 2004 | Clin Cancer Res2004，10，5： | 1 |
| 19 | Therapeu tie intervention for chronic prostatitis/chronic pel vic pain syndrome (CP/CPPS): a systematic re view and meta-analysis显示文摘 | Cohen JM Fagin AP Haritoni E | 2012 | PloS One2012，7，8： | 1 |
| 20 | Attractive bluegreen egg coloration and cuckoo-host coevolution显示文摘 | Soler JJ Avilés JM Moller AP Moreno J | | 0，，： | 1 |
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