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| 1 | Outcomes of submucosal(T1b) esophageal adenocarcinomas removed by endoscopic mucosal resection显示文摘AIM To investigate the outcomes and recurrences of p T1 b esophageal adenocarcinoma(EAC) following endoscopic mucosal resection(EMR) and associated treatments.METHODS Patients undergoing EMR with pathologically confirmed T1 b EAC at two academic referral centers were retrospectively identified.Patients were divided into 4 groups based on treatment following EMR:Endoscopic therapy alone(group A),endoscopic therapy with either chemotherapy,radiation or both(group B),surgicalresection(group C) or no further treatment/lost to follow-up(<12 mo)(group D).Pathology specimens were reviewed by a central pathologist.Follow-up data was obtained from the academic centers,primary care physicians and/or referring physicians.Univariate analysis was performed to identify factors predicting recurrence of EAC.RESULTS Fifty-three patients with T1 b EAC underwent EMR,of which 32(60%) had adequate follow-up ≥ 12 mo(median 34 mo,range 12-103).There were 16 patients in group A,9 in group B,7 in group C and 21 in group D.Median follow-up in groups A to C was 34 mo(range 12-103).Recurrent EAC developed overall in 9 patients(28%) including 6(38%) in group A(median:21 mo,range:6-73),1(11%) in group B(median:30 mo,range:30-30) and 2(29%) in group C(median 21 mo,range:7-35.Six of 9 recurrences were local;of the 6 recurrences,5 were treated with endoscopy alone.No predictors of recurrence of EAC were identified.CONCLUSION Endoscopic therapy of T1 b EAC may be a reasonable strategy for a subset of patients including those either refusing or medically unfit for esophagectomy. | Darren D Ballard Neel Choksi Jingmei Lin Eun-Young Choi B Joseph Elmunzer Henry Appelman Douglas K Rex Hala Fatima William Kessler John M DeWitt | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 2 |
| 2 | Initial experience with routine administration of etanereept in psoriasis 显示文摘 | De Groot M Appelman M Spuls P | 2006 | Br J Dermatol2006，155，4： | 1 |
| 3 | Clinical characteristics of type 1 diabeties patients with and without severe hypoglycemia显示文摘 | ter Braak EW Appelman AM ven de Lank M | 2000 | Diabetes Care2000，23，10： | 1 |
| 4 | Concentration-time mortality response relationship of irritant and systemically acting vapours and gases 显示文摘 | ten Berge W F Zwarl A Appelman L M | 1986 | Journal of Hazardous Materials1986，13，： | 1 |
| 5 | Oxygen-Transfer Reactions of Methylrhenium Oxides显示文摘 | Abu-Omar M M Appelman E H Espenson J H | 1996 | Inorganic Chemistry1996，35，26： | 1 |
| 6 | Escalation in individual and group decision making显示文摘 | BAZERMAN M H GIULIANO T APPELMAN A | 1984 | Organizational Behavior and Human Performance1984，33，： | 1 |
| 7 | Effects of oral exposure to polychlorinated biphenyls (PCBs) on the development and metamorphosis of two amphibian species (Xenopus laevis and Rana temporaria ) 显示文摘 | Gutleb AC Appelman J Bronkhorst M | 2013 | Sci Total Environ2013，262，12： | 1 |
| 8 | Hepatotoxicity following treatmehnt with bromperidol显示文摘 | Van Bellinghen M Peuskens J Appelmans A | 1989 | J Clin Psychopharmacol1989，9，： | 1 |
| 9 | Delayed effects of pre-and-early-life time exposure to polychlorinated biphenyls on tadpoles of two amphibian species(Xenopus laevis and Rana teporaria)显示文摘 | Gutleb A Appelman J Bronkhorset M | 1999 | Environ Toxicol Pharm1999，8，： | 1 |
| 10 | Fluorescent in-situ hybridization (FISH) as an aid to marker chromosome identification in prenatal diag- nosis 显示文摘 | Amiel A Fejgin M Appelman Z | 1995 | Eur J Obstet Gyneeol Reprod Biol1995，59，1： | 1 |
| 11 | Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer 显示文摘 | Carpentino J E Hynes M J Appelman H D | 2009 | Cancer Res2009，69，20： | 1 |
| 12 | Clinical characteristics of type 1 diabeties patients with and without severe hypoglycemia显示文摘 | ter Break EW Appelman AM ven de Laak M | 2000 | Diabetes Care2000，23，10： | 1 |
| 13 | Clinical characteristics of type 1 diabetic patients with and without se- vere hypoglycemia显示文摘 | TER BRAAK E W APPELMAN A M VAN DE IAAK M | 2000 | Diabetes Care2000，23，10： | 1 |
| 14 | Effects of oral exposure to polychlorinated biphenyls(PCBs) on the development and metamorphosis of two amphibian species(Xenopus laevis and Rana temporaria ) 显示文摘 | Gutleb A C Appelman J Bronkhorst M | 2000 | Science of the Total Environment2000，262，1： | 1 |
| 15 | Concentration-time mortality response relationship of irritant and systemically acting vapours and gases显示文摘 | ten Berge W F Zwart A Appelman L M | 1986 | Journal Hazardous Materials1986，13，3： | 1 |
| 16 | Sex differences in cardiovascular risk factors and disease prevention显示文摘 | Appelman Y van Rijn B B Ten Haaf M E | 2015 | Atherosclerosis2015，241，1： | 1 |
| 17 | Effects of oral exposure to polychlorinated biphenyls (PCBs) on the development and metamorphosis of two amphibian species (Xenopus laevis and Rana temporaria)显示文摘 | Gutleb AG Appelman J Bronkhorst M | 2000 | Sci Total Environ2000，262，： | 1 |
| 18 | Treatment of motoneuron degeneration by intracerebroventrieular delivery of VEGF in a rat model of ALS显示文摘 | Storkebaum E Lambreehts D Dewerchin M Moreno-Murciano M P Appelmans S Oh H | 2005 | Nat Neurosci2005，8，： | 1 |
| 19 | Effects of oral exposure to polychlorinated biphenyls (PCBs) on the development and metamorphosis of two amphibian species (Xenopus laevis and Rana temporaria) 显示文摘 | Gutleb A C Appelman J Bronkhorst M | 2000 | Science of the Total Environment2000，262，12： | 1 |
| 20 | Effects of oral exposure to polychlorinated biphenyls (PCBs) on the development and metamorphosis of two amphibian species (Xenopus laevis and Rana temporaria)显示文摘 | Gutleb A G Appelman J Bronkhorst M | 2000 | Sci Total Environ2000，262，： | 1 |
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